INT175194

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (UBC, NUP62) nucleus (UBC, NUP62) nucleoplasm (UBC)
nuclear envelope (NUP62) small molecule metabolic process (NUP62) carbohydrate metabolic process (NUP62)
UBC (Homo sapiens)
NUP62 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 4 12.08 Low Low
Neuritis 8 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 16 53.68 Quite High
Disease 52 49.76 Quite Low
Shock 20 45.48 Quite Low
Alzheimer's Dementia 16 5.00 Very Low Very Low Very Low
Amyloid Plaque 12 5.00 Very Low Very Low Very Low
Neuritis 8 5.00 Very Low Very Low Very Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Organ Transplantation 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Dementia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The specific type of polyubiquitin chain recognized by p62’s UBA domain is not yet known and studies are underway lab to determine p62’s interaction with specific polyubiquitin chains, however, our preliminary studies suggest that p62’s UBA domain may recognize K63 linked polyubiquitin chains.
polyubiquitin Binding (interaction) of p62
1) Confidence 0.01 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.05 Pain Relevance 0
The amino acids 386-434 of p62, which bind polyubiquitin,
has been shown to possess homology to other recently described UBA domains
(9). 
polyubiquitin Binding (bind) of p62
2) Confidence 0.01 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
Our results revealed that HSP70 utilizes K63 linkage to assemble polyubiquitin chains to bind to p62’s UBA domain since only the K63R ubiquitin mutant blocked the ubiquitination of HSP70 (Fig. 8A).
polyubiquitin Binding (bind) of p62
3) Confidence 0.01 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
The specific type of polyubiquitin chain recognized by p62’s UBA domain is not yet known and studies are underway lab to determine p62’s interaction with specific polyubiquitin chains, however, our preliminary studies suggest that p62’s UBA domain may recognize K63 linked polyubiquitin chains.
polyubiquitin Binding (recognized) of p62
4) Confidence 0.01 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0

General Comments

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