INT1752

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2011
Negated 1
Speculated 2
Reported most in Abstract
Documents 109
Total Number 111
Disease Relevance 42.05
Pain Relevance 15.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
brain 15
hippocampus 4
cortex 4
limb 2
synapse 2
Ache (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 92 99.90 Very High Very High Very High
Clonidine 53 99.84 Very High Very High Very High
Serotonin 65 99.80 Very High Very High Very High
Hippocampus 236 99.72 Very High Very High Very High
tetrodotoxin 15 99.68 Very High Very High Very High
Calcium channel 6 99.68 Very High Very High Very High
depression 110 99.28 Very High Very High Very High
sodium channel 3 98.68 Very High Very High Very High
analgesia 11 98.42 Very High Very High Very High
Endogenous opioid 1 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 4240 99.96 Very High Very High Very High
Cognitive Disorder 1735 99.86 Very High Very High Very High
Neuropathic Pain 3 99.76 Very High Very High Very High
Cardiovascular Disorder Under Development 1 99.76 Very High Very High Very High
Frailty 177 99.50 Very High Very High Very High
Poisoning 40 99.44 Very High Very High Very High
Toxicity 98 99.40 Very High Very High Very High
Depression 131 99.28 Very High Very High Very High
Frontotemporal Dementia 132 99.12 Very High Very High Very High
Sleep Disorders 53 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A single injection of disulfoton produced 74, 65 and 27% inhibition of AChE activity after 4, 48 and 96 hr respectively.
Negative_regulation (inhibition) of AChE
1) Confidence 0.59 Published 1982 Journal Biochem. Pharmacol. Section Abstract Doc Link 7150362 Disease Relevance 0 Pain Relevance 0.27
It is possible that a reversible inhibition of acetylcholinesterase by clonidine protects the enzyme from irreversible inactivation by soman, thereby decreasing the extent of chronic cholinergic overstimulation with its attendant down regulation of muscarinic receptors.
Spec (possible) Negative_regulation (inhibition) of acetylcholinesterase associated with clonidine
2) Confidence 0.59 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3614769 Disease Relevance 0 Pain Relevance 0.41
Mice pretreated with the centrally active alpha-2 adrenergic agonist, clonidine, were protected from several of the toxic manifestations of soman, an organophosphate acetylcholinesterase inhibitor.
Negative_regulation (inhibitor) of acetylcholinesterase associated with agonist and clonidine
3) Confidence 0.59 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3761196 Disease Relevance 0.23 Pain Relevance 0.37
The protective effects of clonidine are likely to involve multiple effects, including blockade of acetylcholine release and postsynaptic muscarinic receptors and transient inhibition of acetylcholinesterase.
Negative_regulation (inhibition) of acetylcholinesterase associated with clonidine
4) Confidence 0.59 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3761196 Disease Relevance 0.28 Pain Relevance 0.56
Clonidine noncompetitively inhibited acetylcholinesterase activity in vitro and after in vivo administration at protective doses.
Negative_regulation (inhibited) of acetylcholinesterase associated with clonidine
5) Confidence 0.59 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3761196 Disease Relevance 0.33 Pain Relevance 0.70
The present data showed that the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol inhibited AChE activity in a dose-dependent manner in both the cortex and hippocampus.
Negative_regulation (inhibited) of AChE in hippocampus associated with hippocampus
6) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.22 Pain Relevance 0.05
In the present study, we found that 5 or 10 mg/kg of ethanol extract of Magnolia officinalis or 0.75 or 1.5 mg/kg of 4-O-methylhonokiol has a similar inhibitory effect to 3 mg/kg tacrine on scopolamine-induced memory impairment as well as the inhibition of AChE activity in vivo.
Negative_regulation (inhibition) of AChE associated with cognitive disorder
7) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.41 Pain Relevance 0.08
It is well known that the memory-improving effect of the anti-amnestic effect of tacrine and donepezil is due to the inhibition of AChE in the brain.
Negative_regulation (inhibition) of AChE in brain
8) Confidence 0.58 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.19 Pain Relevance 0.04
These results indicate that the protective activity of eseroline correlates well with its own anti-ChE profile, and that the effectiveness of the protection depends largely on the rate of AChE inhibition by the agents used to inactivate the enzyme.
Negative_regulation (inhibition) of AChE
9) Confidence 0.58 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2858526 Disease Relevance 0 Pain Relevance 0
These results were corroborated with two other specific inhibitors of AChE and BChE, tolserine and bis-norcymserine, respectively.
Negative_regulation (inhibitors) of AChE
10) Confidence 0.58 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.23 Pain Relevance 0.12
Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear.
Negative_regulation (inhibitors) of AChE in brain
11) Confidence 0.58 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.39 Pain Relevance 0.10
These results point to a potential usefulness of BChE inhibitors in the treatment of central cholinergic dysfunction in which brain AChE activity is typically reduced.
Negative_regulation (reduced) of AChE in brain
12) Confidence 0.58 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0 Pain Relevance 0.09
Cholinergic dysfunction is treated with inhibitors of acetylcholinesterase (AChE) while the role of butyrylcholinesterase (BChE) for brain cholinergic function is unclear.
Negative_regulation (inhibitors) of acetylcholinesterase in brain
13) Confidence 0.58 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17212694 Disease Relevance 0.39 Pain Relevance 0.10
The developing brain may be particularly vulnerable to exposure to acetylcholinesterase (AChE) inhibitors because of the role of AChE on neuronal development and the effects of cholinergic pathways in mediating behavioral and hormonal responses to stress.
Negative_regulation (inhibitors) of acetylcholinesterase in neuronal associated with stress
14) Confidence 0.58 Published 2006 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 16283257 Disease Relevance 0.30 Pain Relevance 0.06
CONCLUSIONS: These findings suggest that subchronic administration of TDE might prevent the Abeta25-35 peptides induced memory deficits by decreasing the AChE activity level.
Negative_regulation (decreasing) of AChE
15) Confidence 0.58 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20435125 Disease Relevance 0.07 Pain Relevance 0
Prevention of myoblast fusion by reducing the calcium levels in the medium decreased the total AChE by 70%, and only the 4-6S form was synthesized.
Negative_regulation (decreased) of AChE in myoblast
16) Confidence 0.57 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.22
A reorganization of cholinergic innervation (reduction of acetylcholinesterase-positive fibers in the subiculum; increased fiber density in CA1 and in the dentate gyrus) has also been mentioned [38].
Negative_regulation (reduction) of acetylcholinesterase in dentate gyrus
17) Confidence 0.57 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.81 Pain Relevance 0.08
In addition to its documented effects on acetylcholine metabolism, clonidine was found to be a weak inhibitor of acetylcholinesterase.
Negative_regulation (inhibitor) of acetylcholinesterase associated with clonidine
18) Confidence 0.57 Published 1986 Journal Life Sci. Section Abstract Doc Link 3784771 Disease Relevance 0.69 Pain Relevance 0.59
It is suggested that the organophosphate-induced analgesia is due to a combination of an increased concentration of acetylcholine due to inhibition of acetylcholinesterase combined with a reduced destruction of endogenous opioid-like substances due to organophosphate inhibition of proteases.
Spec (like) Negative_regulation (inhibition) of acetylcholinesterase associated with endogenous opioid and analgesia
19) Confidence 0.57 Published 1984 Journal Life Sci. Section Abstract Doc Link 6708739 Disease Relevance 0.24 Pain Relevance 1.01
Since patients of Alzheimer's disease often exhibit depression as well as memory impairment, dual inhibitors of AChE and serotonin transporter (SERT) would be a better therapeutic method.
Negative_regulation (inhibitors) of AChE associated with cognitive disorder, depression, disease and serotonin
20) Confidence 0.56 Published 2010 Journal Chem. Pharm. Bull. Section Abstract Doc Link 20190429 Disease Relevance 0.56 Pain Relevance 0.31

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