INT175209

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 2.03
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT) small molecule metabolic process (DBT) transferase activity, transferring acyl groups (DBT)
cellular nitrogen compound metabolic process (DBT) cytoplasm (DBT)
Anatomy Link Frequency
MCF-7 3
oocytes 2
hip 1
spine 1
skin 1
DBT (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 28 80.64 Quite High
antagonist 152 55.60 Quite High
agonist 104 54.96 Quite High
rheumatoid arthritis 70 50.00 Quite Low
addiction 2 36.32 Quite Low
imagery 12 30.64 Quite Low
dexamethasone 15 22.08 Low Low
endometriosis 21 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Togavirus Infection 23 98.90 Very High Very High Very High
Starvation 4 93.60 High High
Infection 40 91.20 High High
Polycystic Ovary Syndrome 36 86.72 High High
Reprotox - General 3 114 83.00 Quite High
Insulin Resistance 15 79.92 Quite High
Weight Loss 3 75.16 Quite High
Breast Cancer 119 69.28 Quite High
Death 16 67.88 Quite High
Obesity 33 67.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then investigated the consequences of the E2 treatment on the Ca2+ signal induced by Icilin.
Spec (investigated) Regulation (consequences) of E2
1) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.09 Pain Relevance 0
estradiol (E2) is known to be the main physiological steroid in the breast, we studied the effects of adding E2 on TRPM8 expression in MCF-7 cells cultured under steroid-free conditions.
Regulation (adding) of E2 in MCF-7
2) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0 Pain Relevance 0
The correlation between changes in PICP and BMD in the hip remained significant (-0.260, P = 0.049) after adjusting for the effect of changed E2 levels.
Regulation (effect) of E2 in hip
3) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0 Pain Relevance 0
The correlations between changes in ICTP and BMD in the spine and hip remained significant in the hip (-0.301, P = 0.023) but not in the spine (-0.175, P = 0.194) after adjustment had been made for the effect of changed E2 levels.
Regulation (effect) of E2 in spine
4) Confidence 0.06 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC546286 Disease Relevance 0 Pain Relevance 0
Terry studied a possible role of high E2 levels in mediating the adverse effects of hyperstimulation with PMSG on early embryonic development in the rat [491].
Spec (possible) Regulation (role) of E2
5) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0 Pain Relevance 0
High serum E2 concentrations on the day of hCG injection in high and normal responder patients, regardless of the number of oocytes retrieved and the serum progesterone concentration were found to be detrimental to uterine receptivity [42].
Regulation (concentrations) of E2 in oocytes
6) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.08 Pain Relevance 0.06
Metformin treatment significantly increased the number of mature oocytes, fertilization rates, and number of embryos produced, but did not alter the total number of oocytes or peak E2 levels [353].
Neg (not) Regulation (alter) of E2 in oocytes
7) Confidence 0.04 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266397 Disease Relevance 0.79 Pain Relevance 0.14
Nevertheless, as shown by the current observations using MCF-7 cells, ibandronate had no direct effect on ER expression and did not affect E2-induced receptor down-regulation.
Regulation (affect) of E2 in MCF-7
8) Confidence 0.03 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.19 Pain Relevance 0
Control samples without
HSP70, E1, E2, E3, or GST-WT-Ub were also included. 
Regulation (Control) of E2
9) Confidence 0.03 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
In a mouse model, the in vivo targeting of Venezuelan equine encephalitis virus to skin DCs is required for pathogenesis, and is also regulated by amino acids in E2 [54].
Regulation (regulated) of E2 in skin associated with togavirus infection
10) Confidence 0.02 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.68 Pain Relevance 0
Influence of ibandronate on the mitogenic effect of E2, and on estrogen receptor regulation and activity in MCF-7 cells
Regulation (effect) of E2 in MCF-7
11) Confidence 0.02 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.20 Pain Relevance 0

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