INT175210

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.73
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRAF6) signal transduction (TRAF6) nucleolus (TRAF6)
plasma membrane (TRAF6) nucleus (TRAF6) ligase activity (TRAF6)
TRAF6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 82.28 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 12 89.40 High High
INFLAMMATION 7 82.04 Quite High
Colon Cancer 1 77.52 Quite High
Hepatocellular Cancer 1 76.84 Quite High
Carcinoma 1 75.48 Quite High
Hyperplasia 7 65.36 Quite High
Shock 5 61.84 Quite High
Rheumatoid Arthritis 24 50.68 Quite High
Cholesteatoma 60 50.00 Quite Low
Skin Cancer 3 25.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B cascade by deubiquitinating the TNF receptor-associated factor 2 (TRAF2), TRAF6, and IKK-?
TRAF6 Binding (deubiquitinating) of
1) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2858283 Disease Relevance 0.67 Pain Relevance 0.08
TRAF6 was chosen as an E3 in this in vitro ubiquitination assay due to its RING domain, a common feature of E3 ligases, and the observation that p62 is a scaffold for TRAF6 interaction (46).
TRAF6 Binding (interaction) of
2) Confidence 0.11 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.06 Pain Relevance 0

General Comments

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