INT175216

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Context Info
Confidence 0.10
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
K48 2
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 18 5.00 Very Low Very Low Very Low
Kinase C 14 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 304 98.64 Very High Very High Very High
Acantholysis 65 98.32 Very High Very High Very High
Adhesions 55 91.92 High High
Blister 12 87.00 High High
Shock 14 83.52 Quite High
Glioma 52 80.40 Quite High
Cancer 78 58.12 Quite High
Stress 18 51.32 Quite High
Neurodegenerative Disease 4 50.32 Quite High
Myeloid Leukemia 12 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hence, as presented in our model (Fig. 10), we propose that as TP?
Negative_regulation (presented) of Fig Binding (model) of
1) Confidence 0.10 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Negative_regulation (decreased) of Fig Binding (activity) of
2) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.24 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Negative_regulation (decrease) of Fig Binding (activity) of
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.25 Pain Relevance 0
Out of the five proteins, four proteins (# 2, 3, 4, and 5) showed reduced binding ability with p62’s UBA domain when polyubiquitin K48 chains were included (Fig. 6A, 6B).
Negative_regulation (reduced) of Fig Binding (binding) of in K48
4) Confidence 0.07 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.13 Pain Relevance 0
At present, compelling evidence indicates that acantholysis in PV and in PF is initiated by cellular signalling pathways rather than by direct inhibition of Dsg binding (Fig. 11).
Negative_regulation (inhibition) of Fig Binding (binding) of associated with acantholysis and bullous skin disease
5) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.43 Pain Relevance 0
(ser9) by Akt is also abrogated in presence of Wortmanin (Fig 2A).
Negative_regulation (abrogated) of Fig Binding (presence) of
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0 Pain Relevance 0

General Comments

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