INT175224

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Context Info
Confidence 0.23
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 5.73
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (DAB1)
DAB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Eae 4 100.00 Very High Very High Very High
Hippocampus 2 92.56 High High
Neuritis 8 61.52 Quite High
cerebral cortex 10 21.12 Low Low
Somatosensory cortex 8 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
interneuron 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 6 99.18 Very High Very High Very High
Disease 52 90.88 High High
Shock 20 89.16 High High
Injury 6 87.40 High High
Death 4 75.68 Quite High
Dementia 4 73.40 Quite High
Alzheimer's Dementia 16 67.44 Quite High
Amyloid Plaque 12 67.36 Quite High
Neuritis 8 61.52 Quite High
Malformations Of Cortical Development 14 38.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1) and suppressing tau phosphorylation (29).
Phosphorylation (phosphorylation) of Dab1 associated with eae and disorder of lipid metabolism
1) Confidence 0.23 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 1.44 Pain Relevance 0.11
Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1) and suppressing tau phosphorylation (29).
Phosphorylation (phosphorylation) of Disabled-1 associated with eae and disorder of lipid metabolism
2) Confidence 0.23 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 1.43 Pain Relevance 0.11
Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1) and suppressing tau phosphorylation (29).
Phosphorylation (phosphorylation) of Disabled-1 associated with eae and disorder of lipid metabolism
3) Confidence 0.17 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 1.38 Pain Relevance 0.11
Reelin is a large secreted protein that controls cortical layering by signaling through the very low density lipoprotein receptor and apolipoprotein E receptor 2, thereby inducing tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1) and suppressing tau phosphorylation (29).
Phosphorylation (phosphorylation) of Dab1 associated with eae and disorder of lipid metabolism
4) Confidence 0.17 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 1.38 Pain Relevance 0.11
Reelin signaling requires binding to receptors of the lipoprotein family, very low density-lipoprotein (VLDLR) and the apolipoprotein E receptor (ApoER2), which triggers tyrosine phosphorylation of the cytoplasmic adapter protein Disabled-1 (Dab1) [34], [35], [36].
Phosphorylation (phosphorylation) of Dab1 associated with disorder of lipid metabolism
5) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.10 Pain Relevance 0.05
To further assess the influence of intracellular reelin signaling, we used PP2 (10 ┬ÁM), a Src inhibitor, which blocks Dab1 phosphorylation, as well as LY294002, which by inhibiting PI3K prevents the activation of Akt.
Phosphorylation (phosphorylation) of Dab1
6) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

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