INT175226

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Context Info
Confidence 0.52
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.26
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (NUP62) small molecule metabolic process (NUP62) carbohydrate metabolic process (NUP62)
transmembrane transport (NUP62) cytoplasm (NUP62) nucleocytoplasmic transport (NUP62)
Anatomy Link Frequency
bands 1
NUP62 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 94.48 High High
Pain 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Neuritis 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 98.64 Very High Very High Very High
Necrosis 2 98.36 Very High Very High Very High
Bone Disease 73 97.54 Very High Very High Very High
Hypercalcemia 1 78.60 Quite High
Metabolic Bone Disease 1 76.80 Quite High
Apoptosis 19 65.76 Quite High
Death 11 52.48 Quite High
Togavirus Infection 46 51.20 Quite High
Sprains And Strains 34 30.12 Quite Low
Disease 61 24.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations of the p62/sequestosome 1 (p62/SQSTM1) gene account for most of the sporadic and familial forms of PDB [1-5], and exons 7 and 8, encoding the ubiquitin-binding-associated domain (UBA), host a clustered mutational area [2-5]. p62 acts as a scaffold protein in signalling pathways downstream of the interleukin-1, tumour necrosis factor (TNF)-?
Gene_expression (pathways) of p62 associated with necrosis, cancer and bone disease
1) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 0.99 Pain Relevance 0.05
In addition, p62 is an immediate early response gene product for a variety of
signals (18). 
Gene_expression (early response gene product) of p62
2) Confidence 0.29 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
Each translated pool was resuspended in binding buffer (25 mM
Tris pH 7.5, 125 mM NaCl, 0.1% NP-40) and used as a source of protein in p62
UBA pull down assays. 
Gene_expression (source) of p62
3) Confidence 0.26 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0 Pain Relevance 0
The three main bands in pelleted supernatants likely corresponded to low levels of p62, the E2–E1 doublet (56 and 52 kDa) and C (Figure 3A).
Gene_expression (levels) of p62 in bands
4) Confidence 0.13 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.10 Pain Relevance 0
From their apparent molecular weight, major viral proteins in cell lysates were likely the p62 precursor of the envelope glycoprotein E2 (62 kDa), the envelope glycoprotein E1 (52 kDa), and the capsid C (36 kDa) [25].
Gene_expression (precursor) of p62
5) Confidence 0.11 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904475 Disease Relevance 0.17 Pain Relevance 0

General Comments

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