INT175262

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 22.85
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SH2B2) signal transduction (SH2B2) plasma membrane (SH2B2)
cytoplasm (SH2B2) signal transducer activity (SH2B2)
Anatomy Link Frequency
plasma 1
tongue 1
proximal 1
basal ganglia 1
stem 1
SH2B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 24 100.00 Very High Very High Very High
Catechol-O-methyltransferase 327 99.48 Very High Very High Very High
Pain 71 98.92 Very High Very High Very High
Inflammation 94 98.44 Very High Very High Very High
Multiple sclerosis 166 97.24 Very High Very High Very High
aspirin 70 96.00 Very High Very High Very High
rheumatoid arthritis 40 93.20 High High
antidepressant 34 92.72 High High
Demyelination 18 92.64 High High
withdrawal 6 92.48 High High
Disease Link Frequency Relevance Heat
Anti-phospholipid Antibody Syndrome 775 100.00 Very High Very High Very High
Chorea 108 100.00 Very High Very High Very High
Habitual Abortion 66 99.92 Very High Very High Very High
Systemic Lupus Erythematosus 369 99.84 Very High Very High Very High
Hantavirus Infection 234 99.80 Very High Very High Very High
Disease 236 99.52 Very High Very High Very High
Idiopathic Thrombocytopenic Purpura 2 99.44 Very High Very High Very High
Thrombosis 225 99.00 Very High Very High Very High
Pain 65 98.92 Very High Very High Very High
INFLAMMATION 86 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that the associations between the concomitant use of BZDs or that of APs and the risk of fractures remain constant during the years of usage, assuming the drug use remained constant during the follow-up years.
APs Binding (associations) of
1) Confidence 0.36 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2910682 Disease Relevance 0.31 Pain Relevance 0.20
Jacqmin-Gadda et al. (1998) did not find a positive association between the use of APs and the risk of fractures [15].
APs Neg (not) Binding (association) of
2) Confidence 0.36 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2910682 Disease Relevance 0.11 Pain Relevance 0.11
The "classical" clinical features associated with APS, as originally introduced, include recurrent thrombosis and pregnancy losses.
APS Binding (associated) of associated with anti-phospholipid antibody syndrome and thrombosis related under development
3) Confidence 0.28 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.03 Pain Relevance 0.08
Although the role of malignancies in and their associations with APS are not clear, these are the primary causes that precipitate APS development and progression.
APS Binding (associations) of associated with anti-phospholipid antibody syndrome
4) Confidence 0.28 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.56 Pain Relevance 0.27
On the basis of subjects' pain responsiveness, haplotypes were designated as low (LPS; CGG), average (APS; TCA), or high (HPS; CCG) pain sensitive.
APS Binding (average) of associated with pain and hantavirus infection
5) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 1.18 Pain Relevance 0.78
Tight linkage of these neutral polymorphisms with more recently acquired low activity APS and HPS haplotypes does not satisfy a simple ancestral model and requires the development of a more complex population genetic model to account for pleiotropic selection.
APS Binding (linkage) of associated with hantavirus infection
6) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.63 Pain Relevance 0.38
The 800A and 641T minor alleles located within the structural domain of the val158 region did not significantly alter this local stem-loop structure or nearby structural domains associated with the APS and HPS haplotypes, respectively.
APS Binding (associated) of in stem associated with hantavirus infection
7) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2664927 Disease Relevance 0.71 Pain Relevance 0.05
APS can be found in patients having neither clinical nor laboratory evidence of another definable condition (primary APS), or it may be associated with other diseases (secondary APS, e.g., after SLE).
APS Binding (associated) of associated with anti-phospholipid antibody syndrome, systemic lupus erythematosus and disease
8) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.51 Pain Relevance 0.04
Discussion of therapeutic approaches in APS is beyond the scope of this overview, but most recent advances, especially in CAPS which is the most life-threatening variant of APS, are listed briefly as follows:
APS Binding (variant) of associated with anti-phospholipid antibody syndrome
9) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 1.97 Pain Relevance 0.14
Almost 20 years after its definition, APS has crossed over into many fields of medicine.
APS Binding (crossed) of associated with anti-phospholipid antibody syndrome
10) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.45 Pain Relevance 0.14
It has been proposed that aPLs can provoke chorea by an antigen/antibody mechanism by binding with phospholipids in the basal ganglia.175 In a review study of 50 patients with chorea and APS,17 SLE was found in 58% of the patients, primary APS-in 30%, and the rest 12% of the studied patients suffered from a 'lupus-like' syndrome while, in the same time, the chorea was bilateral in 55% of the total patient population.
APS Binding (binding) of in basal ganglia associated with chorea, syndrome, anti-phospholipid antibody syndrome and systemic lupus erythematosus
11) Confidence 0.21 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628175 Disease Relevance 2.56 Pain Relevance 0.07
Regarding the first concept, it is important to point out that our assay of aPC, aPS, aPE and aCL does not identify the specific plasma antigen responsible for a positive test.
aPS Binding (assay) of in plasma
12) Confidence 0.13 Published 2007 Journal BMC Neurol Section Body Doc Link PMC2219992 Disease Relevance 0.94 Pain Relevance 0.40
Traditional APs like head, mouse, or control devices using tongue or eye movements have not been accepted by patients for control of neuroprosthesis, because these APs hinder their communication ability, which is most important to patients for participation in normal social activities, and the design is not esthetic.
APs Binding (accepted) of in tongue
13) Confidence 0.04 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2944670 Disease Relevance 0.06 Pain Relevance 0
The outcome of pregnancy in untreated women with a history of RM in association with APS is poor with a live birth rate of about 20% whereas treatment with antithrombotic therapy, such as aspirin and heparin or low molecular weight heparin started early in the first trimester of pregnancy has been shown to significantly improve the live birth rate [98,103,104].


APS Binding (association) of associated with aspirin, anti-phospholipid antibody syndrome and habitual abortion
14) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305329 Disease Relevance 1.25 Pain Relevance 0.05
The APS is associated with placental vascular thrombosis, decidual vasculopathy, intervillous fibrin deposition, and placental infarction [21,30].
APS Binding (associated) of associated with anti-phospholipid antibody syndrome, infarction and thrombosis
15) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305329 Disease Relevance 2.20 Pain Relevance 0
More recently, physiological studies of invertebrate axons have revealed functional properties uncharacteristic of vertebrates, such as proximal axons that lack the ability to initiate APs, spikes whose initiation and propagation are confined to particular axon branches, and initiation locations that vary dynamically, depending on the sites and temporal pattern of synaptic inputs [6]–[10].
APs Binding (initiate) of in proximal associated with action potential
16) Confidence 0.02 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0 Pain Relevance 0.08
However, initiation of APs in such giant axons is necessarily slowed, since the rate of depolarization from rest is dependent on membrane capacitance, and therefore, axonal circumference at the initiation site.
APs Binding (initiation) of associated with action potential
17) Confidence 0.02 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2597720 Disease Relevance 0.15 Pain Relevance 0.05
In SLE, primary APS (PAPS) and secondary APS associated with SLE, traditional, and autoimmune-inflammatory factors are involved [40].
APS Binding (associated) of associated with inflammation, anti-phospholipid antibody syndrome and systemic lupus erythematosus
18) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 2.21 Pain Relevance 0.36

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