INT1753

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Context Info
Confidence 0.78
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 38
Total Number 39
Disease Relevance 15.31
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (Ache) extracellular space (Ache) extracellular region (Ache)
cell adhesion (Ache) Golgi apparatus (Ache) plasma membrane (Ache)
Anatomy Link Frequency
neuronal 4
erythrocyte 2
brain 2
skeletal muscle cell 2
muscle cells 2
Ache (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 19 100.00 Very High Very High Very High
Serotonin 11 99.28 Very High Very High Very High
Hippocampus 58 98.44 Very High Very High Very High
Morphine 6 97.96 Very High Very High Very High
Dopamine 61 97.60 Very High Very High Very High
tolerance 10 97.60 Very High Very High Very High
sodium channel 12 97.32 Very High Very High Very High
tetrodotoxin 25 96.40 Very High Very High Very High
withdrawal 8 96.24 Very High Very High Very High
Action potential 24 94.08 High High
Disease Link Frequency Relevance Heat
Congenital Anomalies 37 99.92 Very High Very High Very High
Frontotemporal Dementia 131 99.84 Very High Very High Very High
Targeted Disruption 88 99.60 Very High Very High Very High
Disease 872 99.56 Very High Very High Very High
Muscular Dystrophy 10 99.40 Very High Very High Very High
Mucositis 74 99.30 Very High Very High Very High
Cognitive Disorder 225 98.76 Very High Very High Very High
Disorders Of Creatine Metabolism 2 98.76 Very High Very High Very High
Malignant Hyperthermia 10 98.70 Very High Very High Very High
Stress 33 98.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This synthesis is modulated by a process associated with spontaneous muscle contractile activity since both total enzyme levels and the proportion of A12 AChE expressed on the cell surface are decreased when the cells are grown in the sodium channel blocker tetrodotoxin, which blocks muscle contraction.
Gene_expression (expressed) of A12 AChE in muscle associated with tetrodotoxin and sodium channel
1) Confidence 0.78 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4056799 Disease Relevance 0 Pain Relevance 0.19
When grown in primary cell culture in the absence of neurons, muscle cells from a variety of species synthesize several forms of acetylcholinesterase (AChE), including the collagen-tailed A12 form.
Gene_expression (synthesize) of acetylcholinesterase in muscle cells
2) Confidence 0.78 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4056799 Disease Relevance 0 Pain Relevance 0
When grown in primary cell culture in the absence of neurons, muscle cells from a variety of species synthesize several forms of acetylcholinesterase (AChE), including the collagen-tailed A12 form.
Gene_expression (synthesize) of AChE in muscle cells
3) Confidence 0.78 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4056799 Disease Relevance 0 Pain Relevance 0
We observed that the elevated expression of AChE by scopolamine in both the cortex and hippocampus was decreased by the treatment with 4-O-methylhonokiol (data not shown).
Gene_expression (expression) of AChE in hippocampus associated with hippocampus
4) Confidence 0.78 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.51 Pain Relevance 0.08
The inhibitory effect on the AChE activity may be related to the inhibitory effect of 4-O-methylhonokiol on the expression of AChE.
Gene_expression (expression) of AChE
5) Confidence 0.78 Published 2009 Journal J Nat Med Section Body Doc Link PMC2690856 Disease Relevance 0.51 Pain Relevance 0.08
The distribution of acetylcholinesterase in the brain is studied during the development of morphine tolerance and through a period of withdrawal to elucidate the possible role of this enzyme in producing physical dependence in mice.
Gene_expression (distribution) of acetylcholinesterase in brain associated with physical dependence, tolerance, withdrawal and morphine
6) Confidence 0.68 Published 1983 Journal Brain Res. Bull. Section Abstract Doc Link 6683583 Disease Relevance 0.30 Pain Relevance 0.65
We have studied the appearance, distribution and regulation of acetylcholinesterase (AChE) and acetylcholine receptors (AChRs) in a mouse skeletal muscle cell line (C2), that was originally isolated and described by Yaffe & Saxel [54].
Gene_expression (appearance) of acetylcholinesterase in skeletal muscle cell
7) Confidence 0.66 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.04
Prevention of myoblast fusion by reducing the calcium levels in the medium decreased the total AChE by 70%, and only the 4-6S form was synthesized.
Gene_expression (synthesized) of AChE in myoblast
8) Confidence 0.66 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.23
The emaciated appearance of AChE -/- mice suggested an inability to obtain sufficient nutrition and experiments were undertaken to increase caloric intake.
Gene_expression (appearance) of AChE
9) Confidence 0.60 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12128253 Disease Relevance 0.24 Pain Relevance 0
Three forms of AChE, distinguished by their sedimentation on sucrose gradients, were synthesized: 4-6S, 10S, and 16S.
Gene_expression (synthesized) of AChE
10) Confidence 0.59 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.17
Before innervation during normal embryonic development, both hydrophilic and hydrophobic 16S AChE exist in equal amounts.
Gene_expression (exist) of AChE
11) Confidence 0.59 Published 1991 Journal J. Neurosci. Res. Section Abstract Doc Link 1890703 Disease Relevance 0.07 Pain Relevance 0.07
We have studied the appearance, distribution and regulation of acetylcholinesterase (AChE) and acetylcholine receptors (AChRs) in a mouse skeletal muscle cell line (C2), that was originally isolated and described by Yaffe & Saxel [54].
Gene_expression (appearance) of AChE in skeletal muscle cell
12) Confidence 0.57 Published 1983 Journal Exp. Cell Res. Section Abstract Doc Link 6617773 Disease Relevance 0 Pain Relevance 0.04
Inhibition of HACU by hemicholinium-3 (HC-3) in vivo reduced extracellular levels of ACh by 60% in wild-type mice but by more than 90% in AChE-deficient mice.
Gene_expression (deficient) of AChE
13) Confidence 0.55 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.17
High-affinity choline uptake (HACU), as measured ex vivo in corticohippocampal synaptosomes, was more than doubled in AChE-deficient mice.
Gene_expression (deficient) of AChE
14) Confidence 0.55 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.16
Addition of choline (10 microM) to the perfusion fluid, while ineffective in wild-type animals, more than doubled extracellular ACh levels in AChE-deficient mice.
Gene_expression (deficient) of AChE
15) Confidence 0.55 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 18023504 Disease Relevance 0 Pain Relevance 0.15
Taken together with previous reports, the present results suggest that postsynaptic membrane depolarization-induced Ca2+ fluxes are important in modulating not only the synthesis of 16S AChE, but also the relative proportions of both physicochemical variants of this molecular form of AChE.
Gene_expression (synthesis) of AChE in postsynaptic membrane
16) Confidence 0.53 Published 1991 Journal J. Neurosci. Res. Section Abstract Doc Link 1890703 Disease Relevance 0.09 Pain Relevance 0.09
In this paper, we show that muscle fibers derived from mouse embryos and neonates are also able to synthesize substantial percentages of their AChE as the A12 form when grown in vitro.
Gene_expression (synthesize) of AChE in embryos
17) Confidence 0.52 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 4056799 Disease Relevance 0 Pain Relevance 0.15
While these neurons expressed the cell-surface marker acetylcholinesterase, the presence of this enzyme could not be used to identify DA neurons unequivocally, since it was also observed in nondopaminergic cells.
Gene_expression (expressed) of acetylcholinesterase in DA neurons associated with dopamine
18) Confidence 0.51 Published 1992 Journal Synapse Section Abstract Doc Link 1354396 Disease Relevance 0 Pain Relevance 0.29
No abnormalities in AChE were demonstrable in any of our DMD patients, indicating that human dystrophy is biochemically distinct from certain animal models of dystrophy (e.g., dystrophic mice) where erythrocyte AChE is decreased.
Gene_expression (demonstrable) of AChE in erythrocyte associated with muscular dystrophy and congenital anomalies
19) Confidence 0.49 Published 1979 Journal J Med Section Abstract Doc Link 231077 Disease Relevance 1.09 Pain Relevance 0
In contrast, evidence was found in two known MH carriers, who had normal erythrocyte ATPase activities, for the presence of an altered membrane AChE characterized by an increase in substrate affinity and a large decrease in maximal hydrolytic rate.
Gene_expression (presence) of AChE in erythrocyte associated with malignant hyperthermia
20) Confidence 0.49 Published 1979 Journal J Med Section Abstract Doc Link 231077 Disease Relevance 1.00 Pain Relevance 0.07

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