INT175303

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Context Info
Confidence 0.10
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 5.19
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pnlip) extracellular region (Pnlip) lipid metabolic process (Pnlip)
Pnlip (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 204 98.56 Very High Very High Very High
Inflammation 60 94.64 High High
alcohol 6 93.36 High High
agonist 60 88.96 High High
antagonist 6 83.52 Quite High
metalloproteinase 102 81.68 Quite High
Dismenorea 6 53.52 Quite High
chemokine 18 44.72 Quite Low
cva 12 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pre-term Labor 240 100.00 Very High Very High Very High
Infection 66 99.90 Very High Very High Very High
INFLAMMATION 72 94.64 High High
Premature Birth 54 91.92 High High
Pre-eclampsia 6 90.12 High High
Fetal Death 12 88.64 High High
Apoptosis 18 88.32 High High
Bacterial Respiratory Disease 12 84.60 Quite High
Cerebral Palsy 12 80.08 Quite High
Periventricular Leukomalacia 6 78.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result is surprising, because C3H/HeJ mice, which that lack a functional TLR4, are resistant to PTL induced by E. coli [138,139].


Positive_regulation (induced) of PTL associated with pre-term labor
1) Confidence 0.10 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.72 Pain Relevance 0.16
These molecules may be excellent targets for therapeutic strategies because they are upstream mediators of the proinflammatory cascade that ultimately results in PTL.
Positive_regulation (results) of PTL associated with pre-term labor
2) Confidence 0.10 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.52 Pain Relevance 0.30
-induced PTL in rhesus monkeys, indicating that IL-10 may function at steps downstream from IL-1?
Positive_regulation (induced) of PTL associated with pre-term labor
3) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.82 Pain Relevance 0.07
Furthermore, inhibitors of cyclooxygenases and nitric oxide synthases (iNOS) block LPS-induced PTL in mice [114-116].


Positive_regulation (induced) of PTL associated with pre-term labor
4) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.76 Pain Relevance 0.33
was able to mimic the effects of bacteria by causing PTL, suggesting a causal role for this cytokine in infection-induced PTL [106,107].
Positive_regulation (causing) of PTL associated with pre-term labor, infection and cytokine
5) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 1.10 Pain Relevance 0.38
Infection may cause PPROM and PTL by causing a premature activation of cytokine cascades that in turn, activate the parturition mechanisms described above.
Spec (may) Positive_regulation (cause) of PTL associated with pre-term labor, infection and cytokine
6) Confidence 0.03 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 1.28 Pain Relevance 0.28

General Comments

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