INT175307

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2003
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 7.08
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
alveolar macrophages 6
monocyte 2
placenta 2
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 373 100.00 Very High Very High Very High
spinal inflammation 2 100.00 Very High Very High Very High
Inflammation 206 95.84 Very High Very High Very High
rheumatoid arthritis 120 90.72 High High
agonist 42 81.84 Quite High
Arthritis 9 80.28 Quite High
chemokine 47 78.96 Quite High
alcohol 8 77.96 Quite High
Inflammatory response 38 74.96 Quite High
Inflammatory mediators 10 43.64 Quite Low
Disease Link Frequency Relevance Heat
Low Back Pain 2 100.00 Very High Very High Very High
Hypersensitivity 24 99.68 Very High Very High Very High
Nicotine Addiction 133 99.40 Very High Very High Very High
Pulmonary Disease 83 98.92 Very High Very High Very High
Mycobacterial Infection 190 98.48 Very High Very High Very High
INFLAMMATION 255 95.84 Very High Very High Very High
Osteoarthritis 68 95.36 Very High Very High Very High
Rheumatoid Arthritis 122 90.72 High High
Disease 114 90.24 High High
Asthma 315 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 expression is modified during the monocyte differentiation process
Regulation (modified) of Gene_expression (expression) of TLR2 in monocyte
1) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
No further changes of TLR2 and TLR4 surface expression had been observed within a 24-hour observation period in our pilot study (data not shown).
Neg (No) Regulation (changes) of Gene_expression (expression) of TLR2
2) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.23 Pain Relevance 0
Taken together these results indicate a differential, cell-type-specific ligand-mediated regulation of the expression of TLR2 and TLR4.
Regulation (regulation) of Gene_expression (expression) of TLR2
3) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.05 Pain Relevance 0.15
TLR2, TLR4 and TLR9 mRNA expression in monocyte-derived and alveolar macrophages
Regulation (alveolar macrophages) of Gene_expression (expression) of TLR2 in alveolar macrophages
4) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
Quantitative real-time PCR (qRT-PCR, TaqMan) was performed to determine the relative TLR2, TLR4 and TLR9 mRNA expression levels using the comparative threshold cycle (??
Spec (determine) Regulation (using) of Spec (determine) Gene_expression (expression) of TLR2
5) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
The present work therefore aimed at characterizing the expression of TLR2, TLR4 and TLR9 on human alveolar macrophages.
Regulation (characterizing) of Gene_expression (expression) of TLR2 in alveolar macrophages
6) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.31 Pain Relevance 0
TLR2, TLR4 and TLR9 mRNA expression in monocyte-derived and alveolar macrophages
Regulation (monocyte) of Gene_expression (expression) of TLR2 in alveolar macrophages
7) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
g/ml LTA (target TLR2/TLR6 heterodimer); 2 ?
Regulation (target) of Gene_expression (heterodimer) of TLR2
8) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
Effect of cytokines and LPS on TLR2 and TLR4 gene expression in PBMCs
Regulation (Effect) of Gene_expression (expression) of TLR2 associated with cytokine
9) Confidence 0.36 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 0.87 Pain Relevance 0.34
There was no abnormality in mRNA expression of TLR2 and TLR4 in PMNs (Figure 2c,d).
Neg (no) Regulation (abnormality) of Gene_expression (expression) of TLR2
10) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.62 Pain Relevance 0.04
patients with ankylosing spondylitis and increased expression of TLR2 and TLR4
Regulation (spondylitis) of Gene_expression (expression) of TLR2 associated with spinal inflammation
11) Confidence 0.26 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.64 Pain Relevance 0.77
It is tempting to speculate that this phenomenon also plays a role under conditions of chronic stimulation with bacterial components in vivo as suggested by the missing effect of LPS-stimulation on TLR2 expression on cells from smokers and COPD patients.
Regulation (effect) of Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
12) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.83 Pain Relevance 0.03
It is tempting to speculate that this phenomenon also plays a role under conditions of chronic stimulation with bacterial components in vivo as suggested by the missing effect of LPS-stimulation on TLR2 expression on cells from smokers and COPD patients.
Regulation (stimulation) of Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
13) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.83 Pain Relevance 0.03
Although the levels of TLR-2 and TLR-4 expression did not increase in the human placenta during labor or in response to TNF-?
Regulation (levels) of Gene_expression (expression) of TLR-2 in placenta
14) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.61 Pain Relevance 0.23
The suppressive effects on the development of allergic responses were independent of the presence of Toll-like receptors 2 and 4, IFN-?
Neg (independent) Regulation (independent) of Gene_expression (presence) of Toll-like receptors 2 associated with hypersensitivity
15) Confidence 0.03 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox