INT175312

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Context Info
Confidence 0.45
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 14.80
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IL23A)
Anatomy Link Frequency
macrophages 6
skin 6
respiratory 6
Th17 cells 2
dendritic cells 2
IL23A (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 13 99.64 Very High Very High Very High
rheumatoid arthritis 258 99.56 Very High Very High Very High
psoriasis 501 99.36 Very High Very High Very High
cytokine 281 96.36 Very High Very High Very High
Inflammation 332 96.12 Very High Very High Very High
Central nervous system 59 94.16 High High
chemokine 36 88.48 High High
Etanercept 139 81.16 Quite High
antagonist 10 69.52 Quite High
metalloproteinase 18 38.28 Quite Low
Disease Link Frequency Relevance Heat
Cancer 365 99.84 Very High Very High Very High
Sarcoidosis 42 99.84 Very High Very High Very High
Rheumatoid Arthritis 258 99.56 Very High Very High Very High
Psoriasis 613 99.50 Very High Very High Very High
Infection 353 99.28 Very High Very High Very High
Disease 326 99.20 Very High Very High Very High
INFLAMMATION 348 96.12 Very High Very High Very High
Malaria 163 91.88 High High
Cold Sores 367 90.48 High High
Syndrome 44 89.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tendency to a less pronounced upregulation of IL-23p19 expression in sarcoidosis patients after LPS stimulation, made us believe that this could have an impact on the induction of Th17 cells.
Positive_regulation (upregulation) of Gene_expression (expression) of IL-23p19 in Th17 cells associated with sarcoidosis
1) Confidence 0.45 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.41 Pain Relevance 0
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
Positive_regulation (enhanced) of Gene_expression (production) of IL-23 associated with psoriasis
2) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.02 Pain Relevance 0.45
It is suggested that certain genetic alteration of the IL-23 (p40 and p19) or IL-12 (p40 and p35) subunits as well as the IL-23 receptor or its ligand will lead to enhanced IL-23 production and subsequent psoriasis susceptibility.
Positive_regulation (lead) of Gene_expression (production) of IL-23 associated with psoriasis
3) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.02 Pain Relevance 0.48
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (dependent) of Gene_expression (production) of IL-23 in respiratory associated with psoriasis, disease and infection
4) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.26 Pain Relevance 0.31
, are increased significantly in psoriatic skin in comparison to the other dermal DCs populations, and they are thought to contain an even more specialized DCs subset that has the ability to produce mediators like TNF and intracellular nitric oxide synthase.22 The later have been termed TIP-DCs (TNF and inducible nitric oxide synthase producing DCs), and are held accountable for the production of IL-23.23
Positive_regulation (accountable) of Gene_expression (production) of IL-23 in DCs associated with psoriasis
5) Confidence 0.34 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.44 Pain Relevance 0.20
Even though IL-23 p19/p40 was very low in RA SF, macrophages isolated from RA SF had significantly increased IL-23 p19 mRNA expression (four-fold increase) compared with control macrophages.
Positive_regulation (increased) of Gene_expression (expression) of IL-23 p19 mRNA in macrophages associated with rheumatoid arthritis
6) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.02 Pain Relevance 0.52
Immunohistochemical analyses have revealed p40 and p19 (subunits of IL-23) protein expression in dermal dendritic cells and keratinocytes of lesional psoriatic skin.31,32 Genetic studies have shown that a single nucleotide polymorphism in p40 (the common subunit of both IL-12 and IL-23)33 as well as polymorphisms in the gene encoding p1934 (IL-23 specific) was associated with the development of psoriasis.
Positive_regulation (revealed) of Gene_expression (expression) of p19 in skin associated with psoriasis
7) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.95 Pain Relevance 0.28
Immunohistochemical analyses have revealed p40 and p19 (subunits of IL-23) protein expression in dermal dendritic cells and keratinocytes of lesional psoriatic skin.31,32 Genetic studies have shown that a single nucleotide polymorphism in p40 (the common subunit of both IL-12 and IL-23)33 as well as polymorphisms in the gene encoding p1934 (IL-23 specific) was associated with the development of psoriasis.
Positive_regulation (revealed) of Gene_expression (expression) of IL-23 in skin associated with psoriasis
8) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.95 Pain Relevance 0.28
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (not) of Gene_expression (production) of IL-23 in respiratory associated with psoriasis, disease and infection
9) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.26 Pain Relevance 0.31
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (implicated) of Gene_expression (production) of IL-23 in respiratory associated with psoriasis, disease and infection
10) Confidence 0.26 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.27 Pain Relevance 0.31
In humans, IL-23 is clearly elevated in psoriatic lesions as indicated by increased levels of both p19 and p40 (subunits of IL-23) mRNA in lesional skin as compared to non-lesional skin, but the mRNA levels of p35 (subunit of IL-12) are not.30 These data suggest that IL-23 appears to play a more dominant role than IL-12 in psoriasis.
Positive_regulation (increased) of Gene_expression (levels) of p19 in skin associated with psoriasis
11) Confidence 0.24 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.96 Pain Relevance 0.38
Further, RA SF macrophages stimulated with PGN expressed significantly higher levels of IL-23 mRNA compared with control macrophages treated similarly.
Positive_regulation (levels) of Gene_expression (expressed) of IL-23 mRNA in macrophages associated with rheumatoid arthritis
12) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.04 Pain Relevance 0.55
Interestingly, TLR2 appears to be the key that preferentially induces IL-23 expression in lieu of IL-12 (94).
Positive_regulation (induces) of Gene_expression (expression) of IL-23
13) Confidence 0.19 Published 2009 Journal Parasite Immunology Section Body Doc Link PMC2759986 Disease Relevance 0.94 Pain Relevance 0
and induced IL-23 expression during the acute infection but decreased its expression during the later time points.
Positive_regulation (induced) of Gene_expression (expression) of IL-23 associated with infection
14) Confidence 0.09 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.88 Pain Relevance 0.23
For example, Kortylewski et al. [47] recently showed that p-STAT-3 signaling in the tumor microenvironment induces IL-23, which is mainly produced by tumor-associated macrophages.
Positive_regulation (induces) of Gene_expression (produced) of IL-23 in macrophages associated with cancer
15) Confidence 0.07 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.52 Pain Relevance 0.08
Tumor-associated Tregs express the IL-23 receptor, which activates STAT-3 in this cell type, leading to upregulation of the Treg-specific transcription factor FoxP3 and the immunosuppressive cytokine IL-10 [47].
Positive_regulation (leading) of Gene_expression (express) of IL-23 associated with cancer and cytokine
16) Confidence 0.05 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.58 Pain Relevance 0.09
In human dendritic cells, TLR-2 agonists more efficiently increased production of IL-8 and IL-23 than did TLR-4 agonists [133].
Positive_regulation (increased) of Gene_expression (production) of IL-23 in dendritic cells associated with agonist
17) Confidence 0.04 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 0.31 Pain Relevance 0.58

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