INT175388

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 13.84
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg) lipid metabolic process (Ugcg)
Anatomy Link Frequency
brain 2
ventricles 1
decidua 1
labyrinth 1
immune cells 1
Ugcg (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 54 99.84 Very High Very High Very High
Central nervous system 241 99.72 Very High Very High Very High
central sensitization 2 97.10 Very High Very High Very High
Inflammation 75 96.44 Very High Very High Very High
Inflammatory mediators 14 93.76 High High
Inflammatory response 100 93.08 High High
cva 20 82.00 Quite High
cytokine 32 75.52 Quite High
Dismenorea 2 74.80 Quite High
Catecholamine 16 22.64 Low Low
Disease Link Frequency Relevance Heat
Stress 282 99.82 Very High Very High Very High
Infection 710 99.68 Very High Very High Very High
Cough 10 99.36 Very High Very High Very High
Neurocysticercosis 420 99.12 Very High Very High Very High
Worm Infection 56 98.76 Very High Very High Very High
Brain Death 94 98.68 Very High Very High Very High
Body Weight 14 98.48 Very High Very High Very High
INFLAMMATION 189 96.44 Very High Very High Very High
Coma 30 96.36 Very High Very High Very High
Schistosomiasis 14 93.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we hypothesize that shipment also exaggerates the HPA axis responsiveness for approximately three weeks due to central sensitization of CRF-releasing neurons in the pPVN followed by a phase of reduced CRF release four weeks after shipment that prevents an acute stress-induced release of GCs.


Localization (release) of GCs in neurons associated with stress and central sensitization
1) Confidence 0.37 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.83 Pain Relevance 0.05
The activation of the hypothalamus-pituitary-adrenal axis (HPA axis) during stress stimulates the release of glucocorticoids (GCs) from the adrenal cortex after adrenocorticotrope hormone (ACTH) is secreted from the anterior pituitary [11-13].
Localization (release) of GCs in anterior pituitary associated with stress
2) Confidence 0.32 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 0.44 Pain Relevance 0.05
In parallel, a portion of GCs released during the course of NCC may enter the CSF circulation and divert immune cells to static deposits of antigens located in leptomeninges, ventricles and areas far from the parasite.
Localization (released) of GCs in ventricles associated with neurocysticercosis
3) Confidence 0.14 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 1.14 Pain Relevance 0.28
Dual-labelling revealed strong co-localisation for COX-1 and COX-2 in the spongiotrophoblast and GCs in the JZ, and within the syncytiotrophoblast and cytotrophoblast cells in the labyrinth (Fig. 5c).
Localization (localisation) of GCs in labyrinth
4) Confidence 0.12 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.35 Pain Relevance 0
The continuous release of parasite GCs and the establishment of equilibrium between host response and parasite infection also implies a homeostatic state that would require robust immunoregulatory mechanisms.
Localization (release) of GCs associated with infection
5) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.57 Pain Relevance 0.08
In summary, these experiments confirm that the GCs detected by lectin binding are released by M. corti and this material is phagocytosed by host cells including areas in which parasites were absent.


Localization (released) of GCs
6) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.48 Pain Relevance 0
GCs bound by isolectinB4 were shed in the first days of infection and not resynthesized by the parasite, whereas GCs bound by wheat germ agglutinin and concavalinA were continuously released throughout the infectious process.
Localization (released) of GCs associated with infection
7) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2274955 Disease Relevance 0.85 Pain Relevance 0.07
GCs in the tegument of T. solium metacestodes are also released during infection
Localization (released) of GCs associated with infection
8) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.52 Pain Relevance 0
Some blood vessels can be seen positive for PNA (Figure 4C) but this is not related to parasite released GCs as vessels are equally stained with the lectin in non-infected brain and mock infected controls.
Localization (released) of GCs in vessels
9) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.23 Pain Relevance 0.03
We propose that both the rapid and persistent release of tegumental GCs plays a key role in the well-known immunomodulatory effects of helminths, including immune evasion and life-long inflammatory sequelae seen in many NCC patients.


Localization (release) of GCs associated with inflammation and neurocysticercosis
10) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2274955 Disease Relevance 0.86 Pain Relevance 0.08
GCs released by M. corti are phagocytosed by host cells
Localization (released) of GCs
11) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.22 Pain Relevance 0.03
To confirm that GCs detected by lectin staining are released from T. solium tegument and then ingested by immune cells, a polyclonal antibody against a 12 kD glycoprotein (GP12) from T. solium was used [27].
Localization (released) of GCs in immune cells
12) Confidence 0.12 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.22 Pain Relevance 0.05
However, a sinusoidal pattern or presence of GCs is suggestive of SMZL [51].
Localization (presence) of GCs
13) Confidence 0.12 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.84 Pain Relevance 0
Thus, the constant release and persistence of parasite GCs during the course of NCC most likely leads to a suppressive and immunoregulatory environment that supports parasite establishment and maintenance while minimizing damaging inflammatory responses.
Localization (release) of GCs associated with inflammatory response and neurocysticercosis
14) Confidence 0.11 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 1.15 Pain Relevance 0.24
Samples infected with T. solium also showed continuous release of ConA bound GCs at various times post infection.
Localization (release) of GCs associated with infection
15) Confidence 0.11 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.70 Pain Relevance 0
Our current research is to isolate and characterize the major GCs with distinct release patterns described herein.
Localization (release) of GCs
16) Confidence 0.11 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.59 Pain Relevance 0.15
GCs released by M. corti are phagocytosed by host cells
Localization (released) of GCs
17) Confidence 0.11 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.22 Pain Relevance 0.03
Fate of lectin specific GCs after CNS infection
Localization (Fate) of GCs associated with central nervous system and infection
18) Confidence 0.11 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.49 Pain Relevance 0.09
It is also notable that the GCs migrating into the DB are strongly immunoreactive for COX, and so PGs synthesised by these cells could exert local paracrine effects in the decidua.
Localization (migrating) of GCs in decidua
19) Confidence 0.11 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.43 Pain Relevance 0.07
On multivariate analysis, only the modified GCS and the presence of SSR, determined at the time of admission, were predictive of weaning outcome.
Localization (presence) of GCS
20) Confidence 0.10 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC305355 Disease Relevance 0.20 Pain Relevance 0

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