INT175389

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 8.79
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (Ugcg) Golgi apparatus (Ugcg) lipid metabolic process (Ugcg)
Anatomy Link Frequency
lymphocytes 2
lung 2
leukocytes 1
brainstem 1
cytotrophoblast 1
Ugcg (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 161 100.00 Very High Very High Very High
Multiple sclerosis 19 98.84 Very High Very High Very High
cva 10 98.44 Very High Very High Very High
medulla 28 97.48 Very High Very High Very High
Catecholamine 16 92.52 High High
cytokine 15 82.64 Quite High
chemokine 7 82.20 Quite High
Inflammatory response 60 81.44 Quite High
corticosteroid 10 79.28 Quite High
Central nervous system 39 69.20 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 232 100.00 Very High Very High Very High
Brain Death 47 99.98 Very High Very High Very High
Apoptosis 97 99.60 Very High Very High Very High
Stress 261 99.20 Very High Very High Very High
Multiple Sclerosis 50 99.16 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 216 98.94 Very High Very High Very High
Cv General 4 Under Development 8 98.44 Very High Very High Very High
Brain Injury 5 98.04 Very High Very High Very High
Disease 90 97.04 Very High Very High Very High
Asthma 24 94.34 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, mice which derived from the vendor did not show increased GCs levels after acute stress exposure but still displayed a loss of lymphocytes from the circulation.
Neg (not) Positive_regulation (increased) of GCs in lymphocytes associated with stress
1) Confidence 0.32 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 1.22 Pain Relevance 0.05
It is well established that GCs reveal a high potential to induce apoptosis of lymphocytes [for review see [38]] and, therefore, long-lastingly increased GCs levels in the vendor-derived animals may have induced lymphocyte apoptosis in these animals which resulted in lower lymphocyte numbers in the peripheral blood at 4 weeks after shipment.
Positive_regulation (increased) of GCs in lymphocytes associated with apoptosis
2) Confidence 0.24 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2845127 Disease Relevance 1.23 Pain Relevance 0.08
It is noteworthy that these data are the first piece of evidence indicating that transactivation and apoptosis induction might be dispensable for the anti-inflammatory activity of GCs in the treatment of EAE and MS.
Positive_regulation (dispensable) of GCs associated with multiple sclerosis, inflammation and apoptosis
3) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 1.44 Pain Relevance 0.21
Similarly to the transcripts that were upregulated following LPS administration, RU486 prevented the dowregulation of 25 out of 42 genes, implying that endogenous GCs are required for both upregulation and downregulation of a considerable number of genes.
Positive_regulation (required) of GCs
4) Confidence 0.09 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.13 Pain Relevance 0.12
To confirm that GCs were parasite derived and not the result of upregulation of glycosylated molecules of activated leukocytes, monoclonal antibodies were generated against M. corti molecules.
Positive_regulation (upregulation) of GCs in leukocytes
5) Confidence 0.07 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.28 Pain Relevance 0
With advancing gestational age immunoreactivity increased, principally in the cytotrophoblast cells (2), GCs (2.5) and spongiotrophoblast (1) at E18 and E19 (Fig. 3a,b).
Positive_regulation (increased) of GCs in cytotrophoblast
6) Confidence 0.07 Published 2007 Journal Placenta Section Body Doc Link PMC1895600 Disease Relevance 0.16 Pain Relevance 0
This study suggests that a modified GCS and the presence of SSR are useful predictors of weaning for selected patients admitted to a CVU.
Positive_regulation (modified) of GCS
7) Confidence 0.06 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC305355 Disease Relevance 0.48 Pain Relevance 0
Oral GCs provide benefit in the treatment of COPD exacerbations with a significant reduction in treatment failure and the need for additional medical treatment and shorter hospital stay.43 However, the benefits of oral GCs in the treatment of stable COPD are less evident and convincing given the minimal improvements in lung function and the long-term side effects of oral GC therapy.44 Therefore, although inhaled GCs do have some benefits in the treatment of COPD, particularly in advanced disease, their benefits are limited; both inhaled and oral GC therapies provide more benefit in acute exacerbations: the former prevents the exacerbation and the latter reverses it.
Positive_regulation (inhaled) of GCs in lung associated with chronic obstructive pulmonary disease and disease
8) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 0.97 Pain Relevance 0.06
Although both inhaled and oral glucocorticoids (GCs) are effective at controlling inflammatory lung diseases such as asthma, their effectiveness is substantially less in COPD; therefore, their contribution to the management of stable COPD is limited.3,21 Results published from the TOwards a Revolution in COPD Health (TORCH) study of patients with COPD, with a FEV1 of <60%, indicated that regular use of inhaled GCs may decrease the rate of decline of lung function.22 However, the majority of studies have concluded that the use of regular inhaled GCs has no impact on the long-term progressive decline in FEV1.23–26
Positive_regulation (inhaled) of GCs in lung associated with asthma, pulmonary disease, inflammation and chronic obstructive pulmonary disease
9) Confidence 0.05 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2939685 Disease Relevance 1.66 Pain Relevance 0.23
A condition of imminent brain death requires either a GCS of 3 and the progressive absence of at least three out of six brainstem reflexes, or a FOUR score of E0M0B0R0’.
Positive_regulation (requires) of GCS in brainstem associated with brain death and medulla
10) Confidence 0.04 Published 2010 Journal Intensive Care Med Section Body Doc Link PMC2921050 Disease Relevance 1.23 Pain Relevance 0.35

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox