INT17539

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 5
Speculated 1
Reported most in Abstract
Documents 68
Total Number 74
Disease Relevance 28.47
Pain Relevance 13.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf1) extracellular region (Igf1)
Anatomy Link Frequency
plasma 9
urine 4
spinal cord 3
CNS 2
spinal 2
Igf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 25 100.00 Very High Very High Very High
Spinal cord 20 100.00 Very High Very High Very High
Clonidine 28 99.90 Very High Very High Very High
Somatostatin 19 99.80 Very High Very High Very High
fluoxetine 20 99.60 Very High Very High Very High
Central nervous system 44 99.52 Very High Very High Very High
Neuritis 5 98.40 Very High Very High Very High
Paracetamol 14 98.02 Very High Very High Very High
antagonist 44 97.92 Very High Very High Very High
Hippocampus 28 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 180 100.00 Very High Very High Very High
Breast Cancer 54 99.84 Very High Very High Very High
Growth Problems 8 99.68 Very High Very High Very High
Urological Neuroanatomy 14 99.56 Very High Very High Very High
Endometrial Cancer 48 99.52 Very High Very High Very High
Precocious Puberty 21 99.52 Very High Very High Very High
Diabetes Mellitus-type I 18 99.46 Very High Very High Very High
Experimental Autoimmune Neuritis 4 99.36 Very High Very High Very High
Obesity 40 99.10 Very High Very High Very High
Frailty 48 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGF-I (10 nM) inhibited K(+)- as well as veratridine-evoked ACh release from rat hippocampal slices and the effect is possibly mediated via the activation of a typical IGF-I receptor and the subsequent phosphorylation of the insulin receptor substrate-1 (IRS-1).
Positive_regulation (activation) of IGF-I
1) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 12421625 Disease Relevance 0 Pain Relevance 0.55
Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation.
Positive_regulation (increased) of IGF-I in plasma
2) Confidence 0.68 Published 2008 Journal Growth Horm. IGF Res. Section Body Doc Link 17693108 Disease Relevance 0 Pain Relevance 0
Plasma GH and IGF-I levels were elevated in exercising pregnant rats on D14 and D20, respectively, when compared to controls, and IGFBP-3 levels were increased on D14 and D20.
Positive_regulation (elevated) of IGF-I in Plasma
3) Confidence 0.67 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340176 Disease Relevance 0.16 Pain Relevance 0.09
These results indicate that maternal exercise significantly increases plasma levels of GH, IGF-I and IGFBP-3 in the late period of pregnancy but causes adverse effects on fetal growth.
Positive_regulation (increases) of IGF-I in plasma
4) Confidence 0.67 Published 2006 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 16340176 Disease Relevance 0.15 Pain Relevance 0.08
The intravenous administration of limaprost enhanced increases of spinal cord tissue levels of CGRP, IGF-I, and IGF-I mRNA at 2 h after the induction of SCI.
Positive_regulation (increases) of IGF-I in spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord
5) Confidence 0.67 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.24 Pain Relevance 0.55
Spinal cord tissue levels of CGRP and IGF-I were increased after the induction of SCI, peaking at 2 h postinduction.
Positive_regulation (increased) of IGF-I in Spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord
6) Confidence 0.67 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.20 Pain Relevance 0.55
The intravenous administration of limaprost enhanced increases of spinal cord tissue levels of CGRP, IGF-I, and IGF-I mRNA at 2 h after the induction of SCI.
Positive_regulation (increases) of IGF-I in spinal cord associated with frailty, calcitonin gene-related peptide and spinal cord
7) Confidence 0.67 Published 2010 Journal Transl Res Section Abstract Doc Link 20970752 Disease Relevance 1.25 Pain Relevance 0.55
Administration of GH prior to the caerulein infusion significantly increased GH, IGF-1 and IL-10 blood levels, attenuated harmful effects of AP and reduced histological manifestations of pancreatitis in the rats with intact sensory nerves.
Positive_regulation (increased) of IGF-1 in sensory nerves associated with pancreatitis
8) Confidence 0.65 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.86 Pain Relevance 0.20
Although the variant carriers showed significantly higher levels of IGF-1(in opposition to Yazdanapah), the number of cases of previous myocardial infarction and the severity of coronary atherosclerosis (estimated by the number of significant narrowing lesions in coronary arteries) were similar between both groups.
Positive_regulation (levels) of IGF-1 associated with atherosclerosis and myocardial infarction
9) Confidence 0.65 Published 2010 Journal Protein J Section Body Doc Link PMC2951508 Disease Relevance 0.48 Pain Relevance 0
Insulin-like growth factor-I also stimulates fibroblast synthesis of extracellular matrix (ECM) molecules such as proteoglycans and type I collagen [18,30,37,38], and IGF-I mRNA and protein levels are increased in healing ligaments [39] and tendons [40], respectively.
Positive_regulation (increased) of IGF-I mRNA in ligaments
10) Confidence 0.65 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.23 Pain Relevance 0
Decreased levels of growth hormone, and changes in other endocrine factors, with unloading have been reported [55-60], and the addition of GH in unloaded rats may be simply re-establishing basal GH behavior in unloaded animals allowing the influence of increased IGF-I to proceed.
Positive_regulation (increased) of IGF-I
11) Confidence 0.65 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.07 Pain Relevance 0
As compared with basal levels, incubation of hypothalami with hGH increased IGF-I and SRIF and decreased GRF release.
Positive_regulation (increased) of IGF-I associated with somatostatin
12) Confidence 0.57 Published 1995 Journal Neuroendocrinology Section Abstract Doc Link 7617136 Disease Relevance 0.05 Pain Relevance 0.20
After CLP, PN but not EN was associated with increased IGF-I compared with the levels measured in starved animals.
Positive_regulation (increased) of IGF-I
13) Confidence 0.53 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.37 Pain Relevance 0.22
These differences in SOCS expression appeared independent of the induction of mRNA of the GHR or of IGF-I.
Positive_regulation (induction) of IGF-I
14) Confidence 0.53 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.45 Pain Relevance 0.14
Tamoxifen, which has been related to increased incidence of endometrial carcinoma in women, dramatically increased the IGF-I mRNA levels in rat uterus.
Positive_regulation (increased) of IGF-I mRNA in uterus associated with endometrial cancer
15) Confidence 0.50 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.35 Pain Relevance 0
The rats that received E2 also had an increased level of IGF-I mRNA (9-fold) as compared to the OVX controls (Fig. 1).
Positive_regulation (increased) of IGF-I mRNA
16) Confidence 0.50 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
Thus, repeated FLX treatment leads to upregulation of IGF-1 system is FC.
Positive_regulation (upregulation) of IGF-1 associated with urological neuroanatomy and fluoxetine
17) Confidence 0.50 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.78 Pain Relevance 1.07
It is possible that FLX affect FC neuroplasticity through activation of the IGF-1 system.
Positive_regulation (activation) of IGF-1 associated with urological neuroanatomy and fluoxetine
18) Confidence 0.50 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.76 Pain Relevance 1.03
Increased plasma levels of growth hormone, insulin-like growth factor (IGF)-I and IGF-binding protein 3 in pregnant rats with exercise.
Positive_regulation (Increased) of IGF in plasma
19) Confidence 0.49 Published 2006 Journal Tohoku J. Exp. Med. Section Title Doc Link 16340176 Disease Relevance 0.08 Pain Relevance 0.06
The IGF-I stimulated increase in ER-?
Positive_regulation (stimulated) of IGF-I
20) Confidence 0.47 Published 2004 Journal Breast Cancer Res Section Body Doc Link PMC468665 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox