INT175398

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Context Info
Confidence 0.16
First Reported 2003
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.34
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ERBB2, VEGFA) cell proliferation (ERBB2) signal transduction (ERBB2)
extracellular space (VEGFA) growth (VEGFA) extracellular region (VEGFA)
ERBB2 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 93.52 High High
cINOD 1 78.40 Quite High
palliative 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 76 97.16 Very High Very High Very High
Hypoxia 1 92.80 High High
Non-small-cell Lung Cancer 12 92.40 High High
Colon Cancer 2 80.44 Quite High
INFLAMMATION 1 78.16 Quite High
Apoptosis 8 75.12 Quite High
Testicular Cancer 1 70.24 Quite High
Nicotine Addiction 44 68.44 Quite High
Cancer 108 60.92 Quite High
Skin Cancer 1 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was therefore suggested that the positive association between Her2 and VEGF expression implicates VEGF in the aggressive phenotype exhibited by Her2 overexpression, and this might support the use of combination therapies directed against both Her2 and VEGF (Pegram and Reese 2002; Konecny et al 2004).
Her2 Binding (association) of VEGF
1) Confidence 0.16 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721347 Disease Relevance 0.09 Pain Relevance 0
Other targets include antibodies against VEGF ligand, EGFr or HER2 and inhibition of proteosome activity to counteract NF?
HER2 Binding (ligand) of VEGF
2) Confidence 0.03 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.25 Pain Relevance 0.13

General Comments

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