INT175400

Context Info Confidence 0.00 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.20 Pain Relevance 0

endoplasmic reticulum (RASGRP1, MAP3K5) cytoplasm (RASGRP1, MAP3K5) cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) response to stress (MAP3K5) cytosol (RASGRP1)

Anatomy Link Frequency epithelial cells 1 RASGRP1 (Homo sapiens) MAP3K5 (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 2 5.00 COX-2 inhibitor 1 5.00 cINOD 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Adenocarcinoma 10 97.44 Hyperplasia 2 94.48 Cancer 86 90.96 Genomic Instability 9 90.12 Lung Cancer 76 84.08 Targeted Disruption 3 82.16 Squamous Cell Carcinoma 9 57.12 Carcinoma 2 54.40 Congenital Anomalies 20 50.00 Nicotine Addiction 44 38.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

K-ras, once mutated (most frequently codon 12 G-T transversions), can transform airway epithelial cells [18,19] by activating the ERK-MAP kinase pathway.

ras Positive_regulation (activating) of ERK-MAP kinase in epithelial cells

1) Confidence 0.00 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.20 Pain Relevance 0

General Comments

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