INT175416

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Context Info
Confidence 0.60
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.94
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (EGFR) cell morphogenesis (EGFR) Golgi apparatus (EGFR)
endoplasmic reticulum (EGFR) intracellular (EGFR) enzyme binding (EGFR)
Anatomy Link Frequency
Lung 2
EGFR (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 6 81.76 Quite High
Pain 3 54.32 Quite High
antagonist 4 49.32 Quite Low
cva 9 5.00 Very Low Very Low Very Low
Antihistamine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Somatostatin 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypomagnesemia 10 99.76 Very High Very High Very High
Non-small-cell Lung Cancer 180 98.32 Very High Very High Very High
Toxicity 38 97.84 Very High Very High Very High
Lung Cancer 111 97.80 Very High Very High Very High
Apoptosis 42 96.40 Very High Very High Very High
Malignant Neoplastic Disease 6 95.88 Very High Very High Very High
Hypersensitivity 3 95.28 Very High Very High Very High
Cancer 338 82.96 Quite High
Diarrhoea 5 80.44 Quite High
Exanthema 20 79.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of EGFR inhibition on target genes cyclin-D1, c-myc was evaluated at the RNA level (figure 7).
Regulation (effect) of Negative_regulation (inhibition) of EGFR
1) Confidence 0.60 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 0.78 Pain Relevance 0
Nevertheless, regulation of serum magnesium also depends on gastrointestinal absorption, and an effect of EGFR inhibition on this process cannot be excluded at the present time.


Regulation (effect) of Negative_regulation (inhibition) of EGFR
2) Confidence 0.45 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721306 Disease Relevance 0.39 Pain Relevance 0.08
Hypomagnesemia is a class effect of EGFR inhibitors and is commonly seen with use of cetuximab.107,108

Conclusions

Regulation (effect) of Negative_regulation (inhibitors) of EGFR associated with hypomagnesemia
3) Confidence 0.44 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886327 Disease Relevance 1.07 Pain Relevance 0
Studies are proposed to investigate the value of EGFR inhibition in combination therapy, in earlier stage NSCLC and in lung cancer chemoprevention (STOP trials, SPORE Trial of Lung Cancer Prevention).
Spec (investigate) Regulation (value) of Spec (investigate) Negative_regulation (inhibition) of EGFR in Lung associated with lung cancer and non-small-cell lung cancer
4) Confidence 0.12 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.94 Pain Relevance 0
Erlotinib is a small molecule HER-1/EGFR inhibitor that blocks dysregulated EGFR-mediated intracellular signalling in NSCLC, inhibiting proliferation and permitting apoptosis of malignant cells.
Regulation (dysregulated) of Negative_regulation (inhibitor) of HER-1 associated with malignant neoplastic disease, non-small-cell lung cancer and apoptosis
5) Confidence 0.03 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012552 Disease Relevance 0.76 Pain Relevance 0.05

General Comments

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