INT175419

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.00
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH3) nucleoplasm (NOTCH3) extracellular region (NOTCH3)
plasma membrane (NOTCH3) nucleus (NOTCH3)
Anatomy Link Frequency
Notch 2
alveolar cell 2
lung 2
NOTCH3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 6 19.16 Low Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 9 99.86 Very High Very High Very High
Hyperplasia 6 98.96 Very High Very High Very High
Lung Cancer 228 95.44 Very High Very High Very High
Genomic Instability 27 89.28 High High
Genetic Translocation 3 87.76 High High
Cancer 258 86.44 High High
Chromosome Aberrations 18 82.76 Quite High
Microsatellite Instability 12 57.28 Quite High
Adenocarcinoma 30 54.44 Quite High
Squamous Cell Carcinoma 27 52.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that Notch3 overexpression prevents epithelial differentiation and this may play a significant role in promoting oncogenesis in a subset of lung cancers [54].


Positive_regulation (overexpression) of Gene_expression (overexpression) of Notch3 in lung associated with lung cancer
1) Confidence 0.32 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.03 Pain Relevance 0
The authors developed a transgenic mouse model overexpressing Notch 3 causing neonatal mortality with a phenotype suggestive of alveolar cell hyperplasia.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of Notch 3 in alveolar cell associated with targeted disruption and hyperplasia
2) Confidence 0.32 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.99 Pain Relevance 0
Recently, Dang et al. identified a chromosome 19–15 translocation associated with overexpression of Notch 3 [53].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Notch 3 in Notch
3) Confidence 0.32 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 0.98 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox