INT175423

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 21.81
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TSC1) embryo development (TSC1) protein complex (TSC1)
cytoplasm (TSC1)
TSC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 3 99.12 Very High Very High Very High
methotrexate 1 85.24 High High
Chronic pancreatitis 3 83.12 Quite High
imagery 23 76.20 Quite High
Inflammation 21 74.80 Quite High
addiction 13 66.32 Quite High
palliative 3 49.56 Quite Low
Bioavailability 1 32.40 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1216 100.00 Very High Very High Very High
Myeloid Leukemia 62 100.00 Very High Very High Very High
Watson Syndrome 18 100.00 Very High Very High Very High
Chromosome Aberrations 21 99.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 99.24 Very High Very High Very High
Glioma 12 99.12 Very High Very High Very High
Non-small-cell Lung Cancer 13 99.02 Very High Very High Very High
Congenital Anomalies 48 98.92 Very High Very High Very High
Breast Cancer 38 97.78 Very High Very High Very High
Skin Cancer 73 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tenofovir is currently only approved for use in HIV positive patients but has been to be effective for LAM resistant mutants and for those patients who have failed prior ADV and LAM.
Positive_regulation (effective) of LAM associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.36 Published 2006 Journal Ann Clin Microbiol Antimicrob Section Body Doc Link PMC1459192 Disease Relevance 0.60 Pain Relevance 0
Recently, Nellist et al. [54] found that deletion of isoleucine at amino acid residue 820 of TSC2 and the TSC2 L1511H, C244R and Y598H amino acid substitutions are sufficient to cause TSC.
Positive_regulation (cause) of TSC
2) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0
They excluded the possibility of mosaicism in the parents with this variant and conclude that this deletion is a rare polymorphism that does not cause TSC, but may be a modifier of the TSC phenotype.
Neg (not) Positive_regulation (cause) of TSC
3) Confidence 0.35 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.50 Pain Relevance 0
Habib et al. [65] tried to determine whether genetic variants in OGG1 play a role in susceptibility to AML in TSC patients.
Spec (whether) Positive_regulation (role) of TSC associated with myeloid leukemia
4) Confidence 0.25 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.88 Pain Relevance 0
The R611Q, R611W, A614D, C696Y and V769E substitutions [51] disrupted the tuberin–hamartin interaction, and prevented the phosphorylation of tuberin by PKB, the inhibition of S6 and S6K phosphorylation, and the stimulation of Rheb GTPase activity, cause TSC because they result in major conformational changes to tuberin.
Positive_regulation (cause) of TSC
5) Confidence 0.25 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.05 Pain Relevance 0
Evidence that germ-line mosaicism is not an uncommon phenomenon would increase the estimated risk in cases of sporadic TSC and, thus, would have implications for genetic counselling.
Positive_regulation (increase) of TSC
6) Confidence 0.23 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.33 Pain Relevance 0
Renal AMLs occupy 1-3% of renal tumors and occur in 2 clinical spectrums: sporadic and those associated with TSC.8 TSC is an autosomal disease entity with various characteristics such as mental retardation, adenoma sebaceum, seizure, renal manifestations, and loss of heterozygosity of TSC1 and TSC2 genes.4,9 Although AML is uncommon among the general population, previous studies has shown that 20% of patients with TSC are known to develop AML while on the other hand, more than 50% of AMLs are associated with TSC.7 In this rare setting, tumors tend to be larger, develop earlier in life, and are more often multiple or bilateral.3
Positive_regulation (tend) of TSC associated with myeloid leukemia, convulsion, intellectual impairment, cancer, tuberous sclerosis, renal cancer and disease
7) Confidence 0.06 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2908871 Disease Relevance 1.20 Pain Relevance 0
Inactivating mutations, or loss, results in inactivation of the two encoding tumor suppressor genes p16 and p14.
Positive_regulation (inactivation) of tumor suppressor associated with cancer
8) Confidence 0.05 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902045 Disease Relevance 1.03 Pain Relevance 0
Most NF1 patients carry a constitutional mutation of the NF1 tumor suppressor gene [11].
Positive_regulation (mutation) of tumor suppressor associated with cancer and watson syndrome
9) Confidence 0.05 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.85 Pain Relevance 0
This finding clearly suggests the possible effect of restoring tumor suppressor miRNAs in cancer therapy.
Positive_regulation (restoring) of tumor suppressor associated with cancer
10) Confidence 0.05 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.78 Pain Relevance 0
PTEN is a major tumor suppressor gene that is inactivated in 50% of high-grade gliomas (5).
Positive_regulation (inactivated) of tumor suppressor associated with cancer and glioma
11) Confidence 0.05 Published 2010 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2991767 Disease Relevance 1.53 Pain Relevance 0.04
Using chromatin modifying drugs to activate tumor suppressor miRNAs can regulate target oncogenes, and it may lead to novel cancer therapies in the future. miRNAs can complement other genomic and proteomic biomarkers for cancer diagnosis and prognosis [53,54].
Positive_regulation (activate) of tumor suppressor associated with cancer
12) Confidence 0.04 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2098778 Disease Relevance 1.27 Pain Relevance 0.16
The historical focus of much of this research has been to identify and study the role of specific genetic abnormalities in tumor cells related to chromosomal abnormalities, inactivation of specific tumor suppressor genes, the activation of specific oncogenes, the expression of hormone receptors and growth factor production associated with the development of cancer.
Positive_regulation (inactivation) of tumor suppressor associated with chromosome aberrations, cancer and congenital anomalies
13) Confidence 0.04 Published 2003 Journal Respir Res Section Body Doc Link PMC314397 Disease Relevance 1.10 Pain Relevance 0
The activity of a tumor suppressor must be induced by replacing or enhancing a missing or inactive protein, respectively, rather than repressing an active protein.
Positive_regulation (induced) of tumor suppressor associated with cancer
14) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 1.00 Pain Relevance 0.04
Indeed, there is precedent for transcriptional silencing by methylation to inactivate the second allele of other tumor suppressor genes, including RASSF1A (43,44) and OPCML (45).
Positive_regulation (inactivate) of tumor suppressor associated with cancer
15) Confidence 0.02 Published 2008 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2483574 Disease Relevance 0.75 Pain Relevance 0
But LdT may occur more nonspecific adverse events and can lead more CK elevation than LAM.
Positive_regulation (elevation) of LAM
16) Confidence 0.02 Published 2010 Journal Virol J Section Body Doc Link PMC2939564 Disease Relevance 0.09 Pain Relevance 0
But LdT may cause more nonspecific adverse events and can lead to more CK elevation than LAM.
Positive_regulation (elevation) of LAM
17) Confidence 0.02 Published 2010 Journal Virol J Section Abstract Doc Link PMC2939564 Disease Relevance 0.28 Pain Relevance 0
It has also been demonstrated that exogenous expression of TUSC2 using a nanoparticle-mediated gene transfer technique sensitizes NSCLC cells to cisplatin, resulting in a 4- to 6-fold increase in the TUSC2 tumor suppressor activity.
Positive_regulation (increase) of tumor suppressor associated with cancer and non-small-cell lung cancer
18) Confidence 0.01 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.33 Pain Relevance 0.13
The PTEN gene, which acts as a tumor suppressor gene, is present in individuals and causes increased cancer susceptibility, including those with Cowden's syndrome.
Positive_regulation (acts) of tumor suppressor associated with syndrome and cancer
19) Confidence 0.01 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.20 Pain Relevance 0
Based on the stimulation of AA release by known cancer chemopreventative agents, I have proposed that AA release by cells is associated with cancer chemoprevention [23-27], possibly, but not necessarily, by activating a secreted tumor suppressor phospholipase A2 (PLA2) [28,29].
Positive_regulation (activating) of tumor suppressor associated with cancer
20) Confidence 0.01 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1180457 Disease Relevance 1.49 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox