INT175442

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Context Info
Confidence 0.34
First Reported 2003
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 21.36
Pain Relevance 3.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cel) extracellular space (Cel) extracellular region (Cel)
Golgi apparatus (Cel) protein complex (Cel) cytoplasm (Cel)
Anatomy Link Frequency
eosinophils 2
blood 2
plasma 1
MMA 1
granulocytes 1
Cel (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 212 100.00 Very High Very High Very High
chemokine 30 99.96 Very High Very High Very High
Inflammation 670 99.16 Very High Very High Very High
Inflammatory mediators 16 96.20 Very High Very High Very High
agonist 105 94.44 High High
Inflammatory response 30 88.84 High High
imagery 28 84.80 Quite High
medulla 1 76.32 Quite High
antagonist 50 68.48 Quite High
Central nervous system 23 66.48 Quite High
Disease Link Frequency Relevance Heat
Infection 196 100.00 Very High Very High Very High
Myeloid Leukemia 50 100.00 Very High Very High Very High
Respiratory Syncytial Virus 665 99.98 Very High Very High Very High
Airway Obstruction 98 99.80 Very High Very High Very High
Aids-related Complex 441 99.52 Very High Very High Very High
Sprains And Strains 410 99.36 Very High Very High Very High
Cancer 129 99.28 Very High Very High Very High
Diabetes Mellitus 304 99.26 Very High Very High Very High
INFLAMMATION 633 99.16 Very High Very High Very High
Necrosis 12 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This was accompanied by an increase in lung vascular permeability as reflected by enhanced BAL protein levels in A2AR-deficient mice and a decrease in overall lung function, which was manifested by a decrease in arterial blood oxygen tension as compared to wild-type mice.
Gene_expression (levels) of BAL protein in lung
1) Confidence 0.34 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.62 Pain Relevance 0.24
levels was accounted for by local accumulation in the lung, because BAL concentrations of this cytokine were on average ten times higher than in the systemic circulation, although the BAL volume was at least three times higher than that of a mouse's blood.
Gene_expression (volume) of BAL in blood associated with cytokine
2) Confidence 0.30 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.85 Pain Relevance 0.20
levels was accounted for by local accumulation in the lung, because BAL concentrations of this cytokine were on average ten times higher than in the systemic circulation, although the BAL volume was at least three times higher than that of a mouse's blood.
Gene_expression (volume) of BAL in blood associated with cytokine
3) Confidence 0.30 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.81 Pain Relevance 0.19
When pharmacologic effects of CGS21680 were tested on BAL granulocytes, no LPS was added.
Gene_expression (granulocytes) of BAL in granulocytes
4) Confidence 0.30 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0 Pain Relevance 0.05
eosinophil influx (Figure 5), BAL cytokines

(IL-13) production (Figure 7) in some degree.

Gene_expression (production) of BAL in eosinophil associated with cytokine
5) Confidence 0.27 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.52 Pain Relevance 0.22
These observations of survival were further supported by measurements of BAL and plasma levels of the cytokines tumor necrosis factor ?
Gene_expression (levels) of BAL in plasma associated with necrosis, cancer and cytokine
6) Confidence 0.26 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.95 Pain Relevance 0.10
Compared to SeV inoculated mice treated with PBS, treatment with azithromycin attenuated the expression of multiple BAL chemokines and growth factors (Figure 4A-D, column 2 versus 3).
Gene_expression (expression) of BAL associated with chemokine
7) Confidence 0.26 Published 2010 Journal Respir Res Section Body Doc Link PMC2906448 Disease Relevance 0.62 Pain Relevance 0.32
The reduction in BAL IL-13 levels would
Gene_expression (levels) of BAL
8) Confidence 0.23 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.49 Pain Relevance 0.09
Finally, nasal immunization with N SRS generated strong local and systemic Ab responses, including a massive anti-N IgA Ab production in BAL.
Gene_expression (production) of BAL in nasal associated with immunization
9) Confidence 0.23 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 1.01 Pain Relevance 0.06
Flow cytometry analysis of BAL lymphocytes
Gene_expression (lymphocytes) of BAL in lymphocytes
10) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262139 Disease Relevance 0 Pain Relevance 0
SCB study design, RSV infection, data analyses; AM BAL, formalin fixation, plethysmography; AMG histopathology and special staining; KDO real-time PCR; AMR and MFA plethysmography and BAL; OR data interpretation; HSJ project design, experimental analyses and interpretation.


Spec (analyses) Gene_expression (infection) of BAL associated with infection and respiratory syncytial virus
11) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 0.53 Pain Relevance 0.05
Our studies demonstrated prolonged AO and persistent AHR in both mouse strains, long after any of the cytokines, potentially responsible for persistent inflammation that we measured, became undetectable in BAL samples.
Gene_expression (samples) of BAL associated with inflammation, airway obstruction, sprains and strains and cytokine
12) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 2.23 Pain Relevance 0.38
In the present study we demonstrate significant correlation between BAL MIG concentrations and AO, and viral load dynamics in both strains of mice.
Gene_expression (concentrations) of BAL associated with airway obstruction and sprains and strains
13) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 2.17 Pain Relevance 0.29
SCB study design, RSV infection, data analyses; AM BAL, formalin fixation, plethysmography; AMG histopathology and special staining; KDO real-time PCR; AMR and MFA plethysmography and BAL; OR data interpretation; HSJ project design, experimental analyses and interpretation.


Spec (analyses) Gene_expression (infection) of BAL associated with infection and respiratory syncytial virus
14) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1183251 Disease Relevance 0.53 Pain Relevance 0.05
Th2 cytokine levels in the BAL fluid of C57BL/6 mice were inhibited in comparison with Balb/c mice following sensitization and challenge with Af
Gene_expression (fluid) of BAL associated with aspergillus infection and cytokine
15) Confidence 0.20 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.79 Pain Relevance 0.22
Thus, sensitization and challenge with Af markedly increased SP-D protein content in the SA BAL fraction of both Balb/c and C57BL/6 mice, however the latter show a distinctly greater capability to produce SP-D in response to allergen challenge.
Gene_expression (fraction) of BAL associated with aspergillus infection
16) Confidence 0.20 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.32 Pain Relevance 0
The numbers of eosinophils in the BAL of mice exposed to 3 and 6 aerosols were significantly higher than those exposed to a single OVA aerosol (p < 0.001 and p < 0.001 respectively) but were not significantly different from each other (p = 0.805).
Gene_expression (exposed) of BAL in eosinophils
17) Confidence 0.19 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.06 Pain Relevance 0.03
Fractionation of the BAL is important because of the differential surfactant protein profile that may be recovered from the different fractions: while the majority of the proteinaceous material and SP-D can be found in the SA, most of the phospholipids and all of the hydrophobic surfactant proteins (SP-B and C) are in the LA fraction.
Gene_expression (found) of BAL
18) Confidence 0.18 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.92 Pain Relevance 0.14
Of note, for all groups, no strain differences were found for any BAL parameter in the sham mice at any time point.


Gene_expression (parameter) of BAL associated with sprains and strains
19) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.67 Pain Relevance 0.10
The cytokine response profiles, both gene expression and protein measurements, mirrored the BAL profiles and revealed that the lung response to aspirated MMA-SS and S-Cr involved the pro-inflammatory cytokines IL-6, MCP-1, and TNF-?
Gene_expression (profiles) of BAL in MMA associated with inflammation, aids-related complex and cytokine
20) Confidence 0.14 Published 2008 Journal Part Fibre Toxicol Section Body Doc Link PMC2546436 Disease Relevance 1.77 Pain Relevance 0.24

General Comments

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