INT175443

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 5.78
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb8) intracellular (Hspb8) response to stress (Hspb8)
cytoplasm (Hspb8)
Anatomy Link Frequency
lung 1
eosinophils 1
Hspb8 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 10 98.88 Very High Very High Very High
Inflammation 91 98.20 Very High Very High Very High
Inflammatory response 21 95.76 Very High Very High Very High
cytokine 97 84.12 Quite High
fibrosis 5 55.60 Quite High
chemokine 2 50.28 Quite High
Arthritis 22 5.00 Very Low Very Low Very Low
anesthesia 10 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
rheumatoid arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Eosinophilia 33 100.00 Very High Very High Very High
Asthma 61 99.82 Very High Very High Very High
Targeted Disruption 111 99.16 Very High Very High Very High
INFLAMMATION 113 98.20 Very High Very High Very High
Aspergillus Infection 44 92.80 High High
Coronary Heart Disease 30 92.36 High High
Rheumatoid Arthritis 21 92.28 High High
Hypersensitivity 132 91.36 High High
Synovitis 27 91.28 High High
Sprains And Strains 25 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression level of HSPB8 in tTA/HSPB8 double TG (tTA/HSPB8 TG) mice was twice the NTG level, while expression of the other HSPs tested was unchanged (Figure 5A and B).
Negative_regulation (level) of HSPB8 associated with targeted disruption
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.38 Pain Relevance 0.03
Furthermore, in a mouse model of allergic asthma, treatment with an RXR antagonist decreased the antigen-specific Th2 response leading to reduced serum IgE levels and strongly decreased lung eosinophilia after antigen challenge.
Negative_regulation (reduced) of IgE in lung associated with asthma, antagonist and eosinophilia
2) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.42 Pain Relevance 0.10
In parallel, levels of IL-5 and total IgE in BALF were also significantly diminished in the group treated with 2,500 ug compared to the other 2 groups (50 and 500 ug).
Negative_regulation (diminished) of IgE
3) Confidence 0.01 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2773769 Disease Relevance 1.08 Pain Relevance 0
was in prevention of OVA-specific IgE in CpG-ODN vaccine.
Negative_regulation (prevention) of IgE
4) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.07 Pain Relevance 0
We found that CpG-ODN vaccine resulted in inhibition of OVA-Specific IgE in both WT and IFN-?
Negative_regulation (inhibition) of IgE
5) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.06 Pain Relevance 0
is not an absolute requirement for suppression of airway eosinophilia and IgE.
Negative_regulation (suppression) of IgE associated with eosinophilia
6) Confidence 0.01 Published 2005 Journal Respir Res Section Abstract Doc Link PMC555575 Disease Relevance 0.66 Pain Relevance 0.15
of asthma through suppression of IL-13, IL-5, IgE, eosinophils CCR3 expression, and CD11b
Negative_regulation (suppression) of IgE in eosinophils associated with asthma
7) Confidence 0.01 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.78 Pain Relevance 0.07
Thus, along with Zhang and colleagues [4] and Takeda and colleagues [3] we show that a decreased airway responsiveness in C57BL/6 mice is not accompanied by similar reduction in the total and antigen-specific IgE and IgG1 levels.


Negative_regulation (reduction) of IgE
8) Confidence 0.01 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.33 Pain Relevance 0.07

General Comments

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