INT175449

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Context Info
Confidence 0.55
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 25.70
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sftpd) extracellular region (Sftpd) proteinaceous extracellular matrix (Sftpd)
Anatomy Link Frequency
lung 11
blood 1
ovoid 1
Sftpd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 563 99.82 Very High Very High Very High
cytokine 392 94.00 High High
cva 6 70.08 Quite High
Thoracotomy 4 60.52 Quite High
alcohol 4 55.40 Quite High
imagery 14 46.28 Quite Low
Pain 2 42.72 Quite Low
Inflammatory response 56 35.08 Quite Low
ketamine 28 5.00 Very Low Very Low Very Low
anesthesia 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pleural Solitary Fibrous Tumor 54 100.00 Very High Very High Very High
Pneumonia 56 99.84 Very High Very High Very High
INFLAMMATION 591 99.82 Very High Very High Very High
Hypersensitivity 980 99.56 Very High Very High Very High
Eosinophilia 84 99.52 Very High Very High Very High
Postoperative Complications 2 99.24 Very High Very High Very High
Aspergillus Infection 1232 98.88 Very High Very High Very High
Asthma 140 98.84 Very High Very High Very High
Cancer 82 97.48 Very High Very High Very High
Adhesions 7 96.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that allergic Th2-type inflammation induced production of SP-D, an otherwise constitutively expressed protein in the lung [12].
Gene_expression (production) of SP-D in lung associated with inflammation and hypersensitivity
1) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.04 Pain Relevance 0.20
Although there was a trend towards increases in SP-D mRNA following sensitization and challenge in C57BL/6 mice (184% of non-sensitized control SP-D mRNA), the findings were not statistically significant (Figure 4C and 4D) indicating that a possibly enhanced mRNA transcription may not be the sole requirement for allergic inflammation induced SP-D production.
Gene_expression (production) of SP-D associated with inflammation and hypersensitivity
2) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.60 Pain Relevance 0.11
Thus, sensitization and challenge with Af markedly increased SP-D protein content in the SA BAL fraction of both Balb/c and C57BL/6 mice, however the latter show a distinctly greater capability to produce SP-D in response to allergen challenge.
Gene_expression (produce) of SP-D associated with aspergillus infection
3) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.32 Pain Relevance 0
In contrast to the non-specific upregulation of both hydrophilic surfactant proteins SP-A and SP-D in pneumonia however, allergic airway inflammation selectively affected SP-D production, suggesting distinct regulatory pathways and a specific role for this lung collectin [12].
Gene_expression (production) of SP-D in lung associated with inflammation, hypersensitivity and pneumonia
4) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.19 Pain Relevance 0.21
Immunoblot analysis demonstrated that Af challenge of sensitized C57BL/6 mice induced increased SP-D protein expression in the LA surfactant fraction (352 ± 88% of the naïve control levels) that was 1.6 fold greater than in Balb/c mice (221 ± 36%, p < 0.05).
Gene_expression (expression) of SP-D protein associated with aspergillus infection
5) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.51 Pain Relevance 0.03
Analyses of the BAL cell pellet for SP-D expression showed no significant differences among the groups (not shown) suggesting that cell-associated SP-D does not represent a significant proportion of collectins in this model.
Gene_expression (expression) of SP-D
6) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.70 Pain Relevance 0.09
In support of that, recent studies in mice over expressing IL-4 [30,31], IL-5 [32] and IL-13 [33] in the lung tissue indicated that Th2-type inflammation induced over production of SP-D.
Gene_expression (production) of SP-D in lung associated with inflammation
7) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.77 Pain Relevance 0.13
The mechanisms that may be responsible for enhanced production of SP-D in the lung are unknown.
Gene_expression (production) of SP-D in lung
8) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.72 Pain Relevance 0.13
We have previously shown that allergic Th2-type inflammation induced production of SP-D, an otherwise constitutively expressed protein in the lung [12].
Gene_expression (expressed) of SP-D in lung associated with inflammation and hypersensitivity
9) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.06 Pain Relevance 0.21
In addition, SP-D expression was also significantly greater in naïve C57BL/6 mice (SA BAL SP-D levels were 233% of naïve Balb/c SP-D levels p < 0.05).
Gene_expression (expression) of SP-D
10) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.31 Pain Relevance 0
Regression analysis between SP-D and airway eosinophilia showed a statistically significant positive correlation (r = 0.7305, p < 0.05) indicating that greater inflammation elicits the production of more SP-D in the lung.
Gene_expression (production) of SP-D in lung associated with inflammation and eosinophilia
11) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.68 Pain Relevance 0.13
The fact that SP-D expression was also significantly greater in naïve C57BL/6 mice than in Balb/c mice suggests that baseline production of this collectin in the lung is genetically determined.


Gene_expression (expression) of SP-D in lung
12) Confidence 0.55 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.31 Pain Relevance 0
Enhanced SP-D expression in return may exert a protective immunosuppressive function in the distal airspaces.
Gene_expression (expression) of SP-D
13) Confidence 0.48 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.77 Pain Relevance 0.15
Increases in SP-D expression in lung inflammation have been also described in our laboratory in a different model of inflammation induced by Pneumocystis carinii pneumonia [18,19].
Gene_expression (expression) of SP-D in lung associated with inflammation, pneumonia and pneumocystis pneumonia
14) Confidence 0.48 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.23 Pain Relevance 0.22
C57BL/6 mice had markedly elevated SP-D levels both at baseline and after sensitization and challenge with Af in comparison with Balb/c mice
Gene_expression (levels) of SP-D associated with aspergillus infection
15) Confidence 0.48 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.85 Pain Relevance 0.16
Positive correlations between SP-D levels and airway eosinophilia may indicate a potential common regulatory pathway.
Gene_expression (levels) of SP-D associated with eosinophilia
16) Confidence 0.48 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.67 Pain Relevance 0.13
SP-D mRNA and protein expression was investigated during development of allergic airway changes in a model of Aspergillus fumigatus (Af)-induced allergic inflammation.
Gene_expression (expression) of SP-D associated with inflammation, hypersensitivity and aspergillus infection
17) Confidence 0.43 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.41 Pain Relevance 0.08
Our results demonstrate an inverse relationship between the ability to develop allergen induced AHR and the extent of SP-D production.


Gene_expression (production) of SP-D
18) Confidence 0.43 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.34 Pain Relevance 0.09
Af challenge of sensitized C57BL/6 mice induced a markedly increased SP-D protein expression in the SA surfactant fraction (1,894 ± 170% of naïve controls) that was 1.5 fold greater than the increase in Balb/c mice (1,234 ± 121% p < 0.01).
Gene_expression (expression) of SP-D protein associated with aspergillus infection
19) Confidence 0.43 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.50 Pain Relevance 0.08
To study the relationship between the ability to produce SP-D and develop AHR, a model of Af-induced allergic sensitization was characterized in two inbred mouse strains.
Gene_expression (produce) of SP-D associated with hypersensitivity, sprains and strains and aspergillus infection
20) Confidence 0.43 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.29 Pain Relevance 0.06

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