INT175452

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Context Info
Confidence 0.21
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.78
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
T cells 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 59 100.00 Very High Very High Very High
antagonist 6 99.84 Very High Very High Very High
Multiple sclerosis 122 99.30 Very High Very High Very High
Inflammation 77 94.76 High High
Arthritis 7 85.08 High High
Demyelination 5 78.84 Quite High
rheumatoid arthritis 18 75.20 Quite High
chemokine 4 71.76 Quite High
Central nervous system 28 69.72 Quite High
imagery 22 42.36 Quite Low
Disease Link Frequency Relevance Heat
Multiple Sclerosis 224 99.30 Very High Very High Very High
Aspergillus Infection 44 96.44 Very High Very High Very High
INFLAMMATION 83 94.76 High High
Hypersensitivity 57 93.96 High High
Mycobacterial Infection 33 92.00 High High
Pneumonia 5 86.72 High High
Asthma 10 85.68 High High
Granuloma 1 85.64 High High
Arthritis 2 85.08 High High
Diabetes Mellitus 8 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This process may be genetically regulated and may serve a negative feedback that would inhibit further Th2 activation.
Negative_regulation (inhibit) of Positive_regulation (activation) of Th2
1) Confidence 0.21 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.76 Pain Relevance 0.16
It has been recently shown, the effect of retinoic acid in T cells, with a decrease of the T-helper 1 (Th1) immune response and an increase of Th2 immune response in vitro [10] and in vivo [13].
Negative_regulation (decrease) of Positive_regulation (increase) of Th2 in T cells
2) Confidence 0.19 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.95 Pain Relevance 0.23
While there are clearly some differences in human and murine systems, therapies for MS have nevertheless aimed to either reduce Th1 or Th17 responses or to increase Th2 responses.
Negative_regulation (reduce) of Positive_regulation (increase) of Th2 associated with multiple sclerosis
3) Confidence 0.15 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 1.43 Pain Relevance 0.68
Th2 cytokines may be inhibited by antagonists such as IL-4?
Negative_regulation (inhibited) of Positive_regulation (cytokines) of Th2 associated with antagonist and cytokine
4) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.64 Pain Relevance 0.14

General Comments

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