INT175458

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 19
Disease Relevance 17.86
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sftpd) extracellular region (Sftpd) proteinaceous extracellular matrix (Sftpd)
Anatomy Link Frequency
lung 16
Sftpd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 380 100.00 Very High Very High Very High
cytokine 266 94.00 High High
Inflammatory response 38 35.08 Quite Low
ketamine 19 5.00 Very Low Very Low Very Low
anesthesia 19 5.00 Very Low Very Low Very Low
isoflurane 19 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 665 100.00 Very High Very High Very High
INFLAMMATION 399 100.00 Very High Very High Very High
Pneumonia 38 99.84 Very High Very High Very High
Asthma 95 99.36 Very High Very High Very High
Aspergillus Infection 836 99.24 Very High Very High Very High
Eosinophilia 57 97.66 Very High Very High Very High
Pneumocystis Pneumonia 19 95.48 Very High Very High Very High
Sprains And Strains 304 92.84 High High
Fungal Infection 19 47.68 Quite Low
Injury 19 33.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms that may be responsible for enhanced production of SP-D in the lung are unknown.
Positive_regulation (responsible) of Gene_expression (production) of SP-D in lung
1) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.72 Pain Relevance 0.13
Immunoblot analysis demonstrated that Af challenge of sensitized C57BL/6 mice induced increased SP-D protein expression in the LA surfactant fraction (352 ± 88% of the naïve control levels) that was 1.6 fold greater than in Balb/c mice (221 ± 36%, p < 0.05).
Positive_regulation (induced) of Gene_expression (expression) of SP-D protein associated with aspergillus infection
2) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.52 Pain Relevance 0.03
Although there was a trend towards increases in SP-D mRNA following sensitization and challenge in C57BL/6 mice (184% of non-sensitized control SP-D mRNA), the findings were not statistically significant (Figure 4C and 4D) indicating that a possibly enhanced mRNA transcription may not be the sole requirement for allergic inflammation induced SP-D production.
Positive_regulation (requirement) of Gene_expression (production) of SP-D associated with inflammation and hypersensitivity
3) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.61 Pain Relevance 0.12
Immunoblot analysis demonstrated that Af challenge of sensitized C57BL/6 mice induced increased SP-D protein expression in the LA surfactant fraction (352 ± 88% of the naïve control levels) that was 1.6 fold greater than in Balb/c mice (221 ± 36%, p < 0.05).
Positive_regulation (increased) of Gene_expression (expression) of SP-D protein associated with aspergillus infection
4) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.51 Pain Relevance 0.03
Increases in SP-D expression in lung inflammation have been also described in our laboratory in a different model of inflammation induced by Pneumocystis carinii pneumonia [18,19].
Positive_regulation (Increases) of Gene_expression (expression) of SP-D in lung associated with inflammation, pneumonia and pneumocystis pneumonia
5) Confidence 0.43 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.23 Pain Relevance 0.22
Enhanced SP-D expression in return may exert a protective immunosuppressive function in the distal airspaces.
Positive_regulation (Enhanced) of Gene_expression (expression) of SP-D
6) Confidence 0.43 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.77 Pain Relevance 0.15
In support of that, recent studies in mice over expressing IL-4 [30,31], IL-5 [32] and IL-13 [33] in the lung tissue indicated that Th2-type inflammation induced over production of SP-D.
Positive_regulation (induced) of Gene_expression (production) of SP-D in lung associated with inflammation
7) Confidence 0.35 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.77 Pain Relevance 0.13
C57BL/6 mice had markedly elevated SP-D levels both at baseline and after sensitization and challenge with Af in comparison with Balb/c mice
Positive_regulation (elevated) of Gene_expression (levels) of SP-D associated with aspergillus infection
8) Confidence 0.35 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.85 Pain Relevance 0.16
In contrast to the non-specific upregulation of both hydrophilic surfactant proteins SP-A and SP-D in pneumonia however, allergic airway inflammation selectively affected SP-D production, suggesting distinct regulatory pathways and a specific role for this lung collectin [12].
Positive_regulation (affected) of Gene_expression (production) of SP-D in lung associated with inflammation, hypersensitivity and pneumonia
9) Confidence 0.35 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.20 Pain Relevance 0.21
We have previously shown that allergic Th2-type inflammation induced production of SP-D, an otherwise constitutively expressed protein in the lung [12].
Positive_regulation (induced) of Gene_expression (expressed) of SP-D in lung associated with inflammation and hypersensitivity
10) Confidence 0.35 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.06 Pain Relevance 0.21
These results suggest that enhanced SP-D production in the lung of C57BL/6 mice may contribute to an attenuated AHR in response to allergic airway sensitization.
Positive_regulation (enhanced) of Gene_expression (production) of SP-D in lung associated with hypersensitivity
11) Confidence 0.33 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.23 Pain Relevance 0.06
Our results demonstrate an inverse relationship between the ability to develop allergen induced AHR and the extent of SP-D production.


Positive_regulation (induced) of Gene_expression (production) of SP-D
12) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.35 Pain Relevance 0.09
The mechanisms that may be responsible for enhanced production of SP-D in the lung are unknown.
Positive_regulation (enhanced) of Gene_expression (production) of SP-D in lung
13) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.72 Pain Relevance 0.13
Although there was a trend towards increases in SP-D mRNA following sensitization and challenge in C57BL/6 mice (184% of non-sensitized control SP-D mRNA), the findings were not statistically significant (Figure 4C and 4D) indicating that a possibly enhanced mRNA transcription may not be the sole requirement for allergic inflammation induced SP-D production.
Positive_regulation (induced) of Gene_expression (production) of SP-D associated with inflammation and hypersensitivity
14) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.60 Pain Relevance 0.11
In conclusion, SP-D production was increased in response to allergic airway inflammation in mice sensitized and challenged with Af.
Positive_regulation (increased) of Gene_expression (production) of SP-D associated with inflammation, hypersensitivity and aspergillus infection
15) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.82 Pain Relevance 0.20
We hypothesized that an elevated SP-D production is associated with the impaired ability of C57BL/6 mice to develop allergic AHR.


Positive_regulation (elevated) of Gene_expression (production) of SP-D associated with hypersensitivity
16) Confidence 0.33 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.19 Pain Relevance 0.07
Af challenge of sensitized C57BL/6 mice induced a markedly increased SP-D protein expression in the SA surfactant fraction (1,894 ± 170% of naïve controls) that was 1.5 fold greater than the increase in Balb/c mice (1,234 ± 121% p < 0.01).
Positive_regulation (induced) of Gene_expression (expression) of SP-D protein associated with aspergillus infection
17) Confidence 0.33 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.51 Pain Relevance 0.08
Af challenge of sensitized C57BL/6 mice induced a markedly increased SP-D protein expression in the SA surfactant fraction (1,894 ± 170% of naïve controls) that was 1.5 fold greater than the increase in Balb/c mice (1,234 ± 121% p < 0.01).
Positive_regulation (increased) of Gene_expression (expression) of SP-D protein associated with aspergillus infection
18) Confidence 0.33 Published 2003 Journal Respir Res Section Abstract Doc Link PMC314399 Disease Relevance 1.50 Pain Relevance 0.08
Regression analysis between SP-D and airway eosinophilia showed a statistically significant positive correlation (r = 0.7305, p < 0.05) indicating that greater inflammation elicits the production of more SP-D in the lung.
Positive_regulation (elicits) of Gene_expression (production) of SP-D in lung associated with inflammation and eosinophilia
19) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.68 Pain Relevance 0.13

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