INT17546

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Context Info
Confidence 0.59
First Reported 1981
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 135
Total Number 137
Disease Relevance 60.28
Pain Relevance 77.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 23
neurons 7
bladder 5
sympathetic 5
sciatic nerve 5
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2151 100.00 Very High Very High Very High
Pain 190 100.00 Very High Very High Very High
Inflammation 153 100.00 Very High Very High Very High
cytokine 89 100.00 Very High Very High Very High
Sciatic nerve 86 100.00 Very High Very High Very High
substance P 82 100.00 Very High Very High Very High
Thermal hyperalgesia 82 100.00 Very High Very High Very High
Neurotransmitter 38 100.00 Very High Very High Very High
neurotrophin 3 28 100.00 Very High Very High Very High
interstitial cystitis 14 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 202 100.00 Very High Very High Very High
INFLAMMATION 163 100.00 Very High Very High Very High
Complex Regional Pain Syndromes 15 100.00 Very High Very High Very High
Interstitial Cystitis 14 100.00 Very High Very High Very High
Overactive Bladder 14 99.92 Very High Very High Very High
Neuropathic Pain 201 99.90 Very High Very High Very High
Cancer 20 99.80 Very High Very High Very High
Death 41 99.78 Very High Very High Very High
Apoptosis 53 99.76 Very High Very High Very High
Inflammatory Pain 3 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, low doses of NTX (1 mg/kg) produced no differences in 125I-NGF binding sites, but induced a decrease in NGF levels in hippocampus, septum and neostriatum.
Negative_regulation (decrease) of NGF in hippocampus associated with nerve growth factor and hippocampus
1) Confidence 0.59 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8469378 Disease Relevance 0 Pain Relevance 0.83
Thus suppression of NGF levels in afferent pathways could be useful for treating DSD following SCI.


Negative_regulation (suppression) of NGF
2) Confidence 0.59 Published 2004 Journal J. Urol. Section Body Doc Link 14665959 Disease Relevance 0 Pain Relevance 0
After NGF-Ab treatment NGF levels were significantly decreased by 38% in the L6 spinal cord compared with vehicle treated spinalized rats, in which NGF levels in the L6 spinal cord were 7 times higher than in spinal intact rats.
Negative_regulation (decreased) of NGF-Ab in spinal
3) Confidence 0.59 Published 2004 Journal J. Urol. Section Body Doc Link 14665959 Disease Relevance 0.18 Pain Relevance 0
The decreased level of NGF was similar between sexes.
Negative_regulation (decreased) of NGF
4) Confidence 0.59 Published 2009 Journal J Med Assoc Thai Section Body Doc Link 19938741 Disease Relevance 0 Pain Relevance 0
Eight weeks of Neotrofin treatment prevented depletion of NGF protein in plantar foot skin and sciatic nerve of diabetic rats and increased NGF protein in associated skeletal muscles.
Negative_regulation (depletion) of NGF protein in sciatic nerve associated with nerve growth factor, diabetes mellitus and sciatic nerve
5) Confidence 0.59 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16507305 Disease Relevance 0.42 Pain Relevance 0.45
However, at these doses, neither anti-inflammatory agent reduced the elevated levels of NGF.
Negative_regulation (reduced) of NGF associated with nerve growth factor and inflammation
6) Confidence 0.59 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10653021 Disease Relevance 1.04 Pain Relevance 0.96
Neonatal capsaicin pre-treatment inhibited NGF- and TNBS-induced decrease in colonic pain threshold: 49.4 +/- 5.3 versus 22.3 +/- 1.6 mmHg (p<0.01) for capsaicin versus vehicle in NGF-treated rats and 39.6 +/- 3.3 versus 18.0 +/- 1.0 mm Hg (p<0.001) for capsaicin versus vehicle in TNBS-treated rats.
Negative_regulation (decrease) of NGF associated with pain threshold, nerve growth factor and qutenza
7) Confidence 0.59 Published 2003 Journal Pain Section Abstract Doc Link 14527709 Disease Relevance 0.44 Pain Relevance 1.48
NGF deprivation had this effect only in early postnatal life; treatment from postnatal day 14 to adulthood had no effect.
Negative_regulation (deprivation) of NGF associated with nerve growth factor
8) Confidence 0.59 Published 1991 Journal Nature Section Abstract Doc Link 2014050 Disease Relevance 0 Pain Relevance 0.41
Systemic deprivation of endogenous NGF by injection of anti-NGF antibodies into rat fetuses or by transfer of anti-NGF to the offspring of autoimmunized mothers has provided conflicting results.
Negative_regulation (deprivation) of NGF associated with nerve growth factor
9) Confidence 0.59 Published 1986 Journal Brain Res. Section Abstract Doc Link 2423196 Disease Relevance 0 Pain Relevance 0.74
Blockade of NGF, using either an endogenous antibody or an antibody against the NGF receptor, prevents neural plasticity and bladder overactivity in experimental models of these conditions.
Negative_regulation (Blockade) of NGF in bladder associated with nerve growth factor
10) Confidence 0.59 Published 2006 Journal Nature clinical practice. Urology Section Abstract Doc Link 16470209 Disease Relevance 0.89 Pain Relevance 0.52
Neuropeptides were examined for their effects on the survival of cultured rat superior cervical ganglion cells after acute deprivation of nerve growth factor (NGF).
Negative_regulation (deprivation) of NGF in superior cervical ganglion associated with ganglion cysts, nerve growth factor and neuropeptide
11) Confidence 0.58 Published 1994 Journal Neuropeptides Section Abstract Doc Link 7513383 Disease Relevance 0.49 Pain Relevance 0.35
Neuropeptides were examined for their effects on the survival of cultured rat superior cervical ganglion cells after acute deprivation of nerve growth factor (NGF).
Negative_regulation (deprivation) of nerve growth factor in superior cervical ganglion associated with ganglion cysts, nerve growth factor and neuropeptide
12) Confidence 0.58 Published 1994 Journal Neuropeptides Section Abstract Doc Link 7513383 Disease Relevance 0.49 Pain Relevance 0.35
These data suggest a directional effect, primarily on the unmyelinated sensory population which results in altered nociceptive behavior, induced by the suppression of one endogenous factor, NGF.
Negative_regulation (suppression) of NGF associated with nociception and unmyelinated
13) Confidence 0.58 Published 1991 Journal Exp. Neurol. Section Abstract Doc Link 1915734 Disease Relevance 0.27 Pain Relevance 0.36
The early decrease of trkA mRNA is likely due to deprivation of target-derived NGF, which is caused by nerve ligation, and the recovery might be because substitute sources of NGF become available.
Negative_regulation (deprivation) of NGF in nerve associated with nerve growth factor
14) Confidence 0.58 Published 1999 Journal Exp Brain Res Section Abstract Doc Link 10442405 Disease Relevance 0.31 Pain Relevance 0.54
Membrane depolarization with elevated K+ is known to prevent neuronal death following NGF deprivation and/or to promote survival via a Ca(2+)-dependent mechanism.
Negative_regulation (deprivation) of NGF in neuronal associated with nerve growth factor and death
15) Confidence 0.58 Published 1997 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 9099612 Disease Relevance 0.66 Pain Relevance 0.28
Veratridine delays apoptotic neuronal death induced by NGF deprivation through a Na(+)-dependent mechanism in cultured rat sympathetic neurons.
Negative_regulation (deprivation) of NGF in sympathetic associated with apoptosis and death
16) Confidence 0.58 Published 1997 Journal Int. J. Dev. Neurosci. Section Title Doc Link 9099612 Disease Relevance 0.71 Pain Relevance 0.28
NT-3 levels in the plantar skin were much higher than NGF levels (1.24 and 0.14 ng/g tissue, respectively) before CFA injection, but decreased significantly 6 h to 48 h after the injection while NGF was markedly induced at 6 h but decreased thereafter.
Negative_regulation (decreased) of NGF in skin associated with nerve growth factor
17) Confidence 0.58 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10713396 Disease Relevance 0.75 Pain Relevance 0.85
The NGF levels in the bladder tissue were significantly increased in patients with IC and decreased to normal level after treatment in responders.


Negative_regulation (decreased) of NGF in bladder
18) Confidence 0.58 Published 2007 Journal Urology Section Body Doc Link 17905097 Disease Relevance 0 Pain Relevance 0
The NGF mRNA levels decreased significantly in responders and were significantly decreased after BTX-A in 11 patients with a visual analog pain scale reduction of 2 or more.
Negative_regulation (decreased) of NGF
19) Confidence 0.58 Published 2007 Journal Urology Section Body Doc Link 17905097 Disease Relevance 0.06 Pain Relevance 0
The NGF mRNA levels decreased significantly in responders and were significantly decreased after BTX-A in 11 patients with a visual analog pain scale reduction of 2 or more.
Negative_regulation (decreased) of NGF
20) Confidence 0.58 Published 2007 Journal Urology Section Body Doc Link 17905097 Disease Relevance 0.06 Pain Relevance 0

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