INT175462

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 6.62
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sftpd) extracellular region (Sftpd) proteinaceous extracellular matrix (Sftpd)
Anatomy Link Frequency
lung 4
Sftpd (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 220 98.44 Very High Very High Very High
cytokine 154 83.84 Quite High
Inflammatory response 22 24.92 Low Low
ketamine 11 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
isoflurane 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pneumonia 22 99.84 Very High Very High Very High
Aspergillus Infection 484 99.80 Very High Very High Very High
Hypersensitivity 385 99.08 Very High Very High Very High
INFLAMMATION 231 98.44 Very High Very High Very High
Pneumocystis Pneumonia 11 98.32 Very High Very High Very High
Asthma 55 90.84 High High
Sprains And Strains 176 80.52 Quite High
Injury 11 33.52 Quite Low
Disease 11 29.16 Quite Low
Rhinitis 22 15.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since changes in mRNA expression were not proportional to those in protein expression (an approximately two fold increase in SP-D mRNA accompanied a nearly 20 fold enhancement in SP-D protein), we speculate that in addition to transcriptional regulation, metabolism of this lung collectin may also be significantly affected during allergic inflammation and a reduced recycling or an increased half life may contribute to its accumulation [30].
Positive_regulation (enhancement) of SP-D protein in lung associated with inflammation and hypersensitivity
1) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.70 Pain Relevance 0.13
Since changes in mRNA expression were not proportional to those in protein expression (an approximately two fold increase in SP-D mRNA accompanied a nearly 20 fold enhancement in SP-D protein), we speculate that in addition to transcriptional regulation, metabolism of this lung collectin may also be significantly affected during allergic inflammation and a reduced recycling or an increased half life may contribute to its accumulation [30].
Positive_regulation (increase) of SP-D in lung associated with inflammation and hypersensitivity
2) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.64 Pain Relevance 0.13
Thus, sensitization and challenge with Af markedly increased SP-D protein content in the SA BAL fraction of both Balb/c and C57BL/6 mice, however the latter show a distinctly greater capability to produce SP-D in response to allergen challenge.
Positive_regulation (increased) of SP-D protein associated with aspergillus infection
3) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.32 Pain Relevance 0
To confirm the selectivity of SP-D upregulation in C57BL/6 mice during allergic airway inflammation we also analyzed the LA and SA surfactant fractions for SP-A, the other member of the hydrophilic surfactant protein (lung collectin) family.
Positive_regulation (upregulation) of SP-D in lung associated with inflammation and hypersensitivity
4) Confidence 0.49 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.68 Pain Relevance 0.14
SP-D increase following Af-challenge of sensitized mice was selective in both C57BL/6 and Balb/c mice
Positive_regulation (increase) of SP-D associated with aspergillus infection
5) Confidence 0.43 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.42 Pain Relevance 0.03
Although there was a trend towards increases in SP-D mRNA following sensitization and challenge in C57BL/6 mice (184% of non-sensitized control SP-D mRNA), the findings were not statistically significant (Figure 4C and 4D) indicating that a possibly enhanced mRNA transcription may not be the sole requirement for allergic inflammation induced SP-D production.
Positive_regulation (increases) of SP-D associated with inflammation and hypersensitivity
6) Confidence 0.43 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.40 Pain Relevance 0.04
We speculate that enhanced SP-D levels may be responsible for an impaired ability of C57BL/6 mice to develop allergen induced AHR.


Positive_regulation (enhanced) of SP-D
7) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.69 Pain Relevance 0.16
In the SA surfactant fraction (where the majority of this protein may be found), Af challenge of sensitized C57BL/6 mice induced a 1,894 ± 170% increase in SP-D from the naïve control group, that was 1.5 fold greater than the 1,269 ± 142% increase in Balb/c mice (p < 0.01 Figure 4A and 4B).
Positive_regulation (increase) of SP-D associated with aspergillus infection
8) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.26 Pain Relevance 0
C57BL/6 mice had markedly elevated SP-D levels both at baseline and after sensitization and challenge with Af in comparison with Balb/c mice
Positive_regulation (elevated) of SP-D associated with aspergillus infection
9) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.85 Pain Relevance 0.16
To study whether the increases in SP-D levels correlated with total mRNA levels, we also analyzed SP-D mRNA expression.
Spec (whether) Positive_regulation (increases) of SP-D
10) Confidence 0.33 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.43 Pain Relevance 0.03
In contrast to the non-specific upregulation of both hydrophilic surfactant proteins SP-A and SP-D in pneumonia however, allergic airway inflammation selectively affected SP-D production, suggesting distinct regulatory pathways and a specific role for this lung collectin [12].
Positive_regulation (upregulation) of SP-D in lung associated with inflammation, hypersensitivity and pneumonia
11) Confidence 0.29 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 1.23 Pain Relevance 0.22

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