INT1755

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Context Info
Confidence 0.26
First Reported 1977
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 8.32
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
stomach mucosa 2
neuronal 2
plaque 2
hepatocytes 1
cardiomyocytes 1
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 24 100.00 Very High Very High Very High
monoamine 21 100.00 Very High Very High Very High
Inflammation 29 99.98 Very High Very High Very High
action potential duration 92 99.80 Very High Very High Very High
cINOD 14 97.72 Very High Very High Very High
Buprenorphine 7 97.20 Very High Very High Very High
agonist 1 94.40 High High
anesthesia 12 94.00 High High
Morphine 2 93.84 High High
antagonist 6 93.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 38 99.98 Very High Very High Very High
Atherosclerotic Plaque 6 99.84 Very High Very High Very High
Malignant Hyperthermia 5 99.50 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 15 99.46 Very High Very High Very High
Disorders Of Creatine Metabolism 4 99.32 Very High Very High Very High
Toxicity 21 99.04 Very High Very High Very High
Nephrotoxicity 1 98.76 Very High Very High Very High
Hypoxia 9 97.60 Very High Very High Very High
Fabry Disease 62 97.52 Very High Very High Very High
Congenital Anomalies 16 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Irreversible binding is increased by microsomal enzyme induction and by anaerobic conditions.
Gene_expression (induction) of enzyme
1) Confidence 0.26 Published 1977 Journal Environ Health Perspect Section Abstract Doc Link PMC1475353 Disease Relevance 0.18 Pain Relevance 0.52
It has been reported that a single dose of GBE does not produce potent pharmacological activities, and repeated doses are needed to produce beneficial effects over a long period of administration (36–38).
Neg (not) Gene_expression (produce) of GBE
2) Confidence 0.12 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0 Pain Relevance 0.07
In the cardiovascular system, GBE does not affect heart rate and contractility, but produces a concentration-dependent increase in coronary flow (12,13).
Gene_expression (produces) of GBE in cardiovascular system
3) Confidence 0.12 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.16 Pain Relevance 0.32
Simultaneously, GBE prolonged the APD, whereas bilobalide shortened it.
Gene_expression (prolonged) of GBE associated with action potential duration
4) Confidence 0.12 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.28 Pain Relevance 0.28
In our previous experiments, however, we have found that GBE prolongs the action potential duration (APD), whereas bilobalide, a main constituent, shortens the APD in cardiomyocytes (14).
Gene_expression (prolongs) of GBE in cardiomyocytes associated with action potential duration
5) Confidence 0.12 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.14 Pain Relevance 0.34
Two different approaches to obtain recombinant IDS have been utilized: production of the recombinant enzyme by a transfected human clone (Bosc 23 cells); production of the recombinant enzyme by adenoviral transduction of neuronal (SK-N-BE) or glial (C6) cells.
Gene_expression (production) of enzyme in neuronal
6) Confidence 0.06 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12393174 Disease Relevance 0.30 Pain Relevance 0.12
Two different approaches to obtain recombinant IDS have been utilized: production of the recombinant enzyme by a transfected human clone (Bosc 23 cells); production of the recombinant enzyme by adenoviral transduction of neuronal (SK-N-BE) or glial (C6) cells.
Gene_expression (production) of enzyme in neuronal
7) Confidence 0.06 Published 2002 Journal Biochim. Biophys. Acta Section Abstract Doc Link 12393174 Disease Relevance 0.32 Pain Relevance 0.13
However, human kidney tissue expresses COX-2 enzyme, suggesting a role for this isoform in maintenance of physiological renal processes.
Gene_expression (expresses) of enzyme in kidney
8) Confidence 0.04 Published 2002 Journal Expert Opin Drug Saf Section Abstract Doc Link 12904160 Disease Relevance 0.36 Pain Relevance 0.36
Among the UGT2B subfamily, UGT2B7, a UGT enzyme present in the liver and several steroid target tissues, is an important member since it conjugates a large variety of compounds including estrogens, androgens, morphine, AZT, and retinoic acid.
Gene_expression (present) of enzyme in liver associated with morphine
9) Confidence 0.03 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10833461 Disease Relevance 0.11 Pain Relevance 0.14
Recently, the pharmaceutical industry has employed the high-throughput method for the evaluation of cytochrome P450 (CYP) inhibition, using a combination of the heterologously expressed enzyme and a fluoregenic substrate.
Gene_expression (expressed) of enzyme
10) Confidence 0.03 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15684471 Disease Relevance 0 Pain Relevance 0.48
We have here expressed and purified a recombinant enzyme (designated as DBDH) from this cDNA.
Gene_expression (expressed) of enzyme
11) Confidence 0.03 Published 1998 Journal J. Biochem. Section Abstract Doc Link 9792917 Disease Relevance 0.07 Pain Relevance 0.07
Evidence is accumulating that COX-2 might not only be considered as a putatively detrimental enzyme but rather a highly regulated enzyme that also contributes to tissue protection and is even constitutively expressed in healthy human stomach mucosa.
Gene_expression (expressed) of enzyme in stomach mucosa
12) Confidence 0.02 Published 2000 Journal Curr. Med. Chem. Section Abstract Doc Link 11032962 Disease Relevance 0.38 Pain Relevance 0.40
Evidence is accumulating that COX-2 might not only be considered as a putatively detrimental enzyme but rather a highly regulated enzyme that also contributes to tissue protection and is even constitutively expressed in healthy human stomach mucosa.
Gene_expression (expressed) of enzyme in stomach mucosa
13) Confidence 0.02 Published 2000 Journal Curr. Med. Chem. Section Abstract Doc Link 11032962 Disease Relevance 0.32 Pain Relevance 0.40
The recombinant enzyme agalsidase alfa (Replagal™, Shire Human Genetic Therapies (HGT), Inc., Cambridge, MA, USA) is produced in a cultured human cell line following the activation of the relevant encoding gene.
Gene_expression (produced) of enzyme
14) Confidence 0.02 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721310 Disease Relevance 0.56 Pain Relevance 0
APN is a ubiquitous enzyme present in a wide variety of human organs, tissues and cell types (endothelial, epithelial, fibroblast, leukocyte).
Gene_expression (present) of enzyme in leukocyte
15) Confidence 0.02 Published 2007 Journal Curr. Med. Chem. Section Abstract Doc Link 17346152 Disease Relevance 0.15 Pain Relevance 0.15
COX-2 is an inducible enzyme produced by many cell types in response to multiple stimuli.
Gene_expression (produced) of enzyme
16) Confidence 0.02 Published 2007 Journal Mini Rev Med Chem Section Abstract Doc Link 17584158 Disease Relevance 0.56 Pain Relevance 0.31
Lopinavir is a highly potent and selective inhibitor of the HIV type 1 (HIV-1) protease, an essential enzyme for production of mature, infective virus.
Gene_expression (production) of enzyme associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.02 Published 2003 Journal Drugs Section Abstract Doc Link 12662125 Disease Relevance 0.92 Pain Relevance 0
However, the production of high amounts of enzyme is hampered by the known refractiveness of FAAH to overexpression.
Gene_expression (production) of enzyme
18) Confidence 0.01 Published 2008 Journal Amino Acids Section Abstract Doc Link 17476568 Disease Relevance 0.18 Pain Relevance 0.13
Isoenzyme fractionation of LDH and CPK indicated skeletal muscle as the source of the elevated enzyme activity.
Gene_expression (source) of enzyme in skeletal muscle associated with disorders of creatine metabolism
19) Confidence 0.01 Published 1977 Journal J Am Geriatr Soc Section Abstract Doc Link 856906 Disease Relevance 0.82 Pain Relevance 0.12
Human liver microsomes, cDNA-expressed enzyme, and hepatocytes are commonly used in in-vitro models for the investigation of mechanism-based inhibition of CYP3A4 (Silverman 1998).
Gene_expression (expressed) of enzyme in hepatocytes
20) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661603 Disease Relevance 0 Pain Relevance 0.07

General Comments

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