INT175506

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Context Info
Confidence 0.32
First Reported 2003
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Map2k1) cytoplasm (Map2k1) cytosol (Map2k1)
cell proliferation (Map2k1) mitosis (Map2k1) cell motility (Map2k1)
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 15 97.36 Very High Very High Very High
Bile 1 55.28 Quite High
Perioperative pain 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 55 98.80 Very High Very High Very High
Cancer 144 97.96 Very High Very High Very High
Hepatocellular Cancer 36 88.72 High High
Colon Cancer 90 86.48 High High
Cirrhosis 5 59.16 Quite High
Intestinal Cancer 16 57.32 Quite High
Adhesions 4 49.24 Quite Low
Death 11 48.12 Quite Low
Metastasis 24 44.40 Quite Low
Injury 2 11.16 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MEK1 or MEK2 activation had no significant effect on the expression of the pro-apoptotic proteins Bax and Bak in these cells (data not shown).


Neg (no) Regulation (effect) of Positive_regulation (activation) of MEK1 associated with apoptosis
1) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.66 Pain Relevance 0
However, activation of either MEK1 or MEK2 markedly up-regulated the expression of MMP-13 protein (Fig. 4A).
Regulation (regulated) of Positive_regulation (activation) of MEK1
2) Confidence 0.32 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.20 Pain Relevance 0.20
To elucidate the role of MEK1/2 activation in the growth and survival of hepatocarcinoma cells, we challenged human HepG2 cells with either vehicle or 10 ?
Regulation (role) of Positive_regulation (activation) of MEK1
3) Confidence 0.20 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.72 Pain Relevance 0.03

General Comments

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