INT175507

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.91
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
pore 2
brain 2
adult brain 2
lung 2
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
cva 26 97.56 Very High Very High Very High
Morphine 60 97.52 Very High Very High Very High
cytokine 21 92.80 High High
agonist 15 91.52 High High
ischemia 5 86.92 High High
Inflammation 95 72.36 Quite High
alcohol 15 50.00 Quite Low
Hippocampus 76 37.68 Quite Low
Inflammatory response 20 21.04 Low Low
Eae 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 484 100.00 Very High Very High Very High
Neurodegenerative Disease 181 100.00 Very High Very High Very High
Hemorrhagic Shock 51 99.32 Very High Very High Very High
Infection 59 98.92 Very High Very High Very High
Sprains And Strains 93 98.16 Very High Very High Very High
Hemorrhage 26 97.56 Very High Very High Very High
Death 182 94.60 High High
Cancer 138 94.20 High High
Toxicity 21 93.60 High High
Colon Cancer 48 90.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Influence of Dox treatment on Bax expression
Regulation (Influence) of Gene_expression (expression) of Bax
1) Confidence 0.50 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.16 Pain Relevance 0
g/ml, pro-apoptotic protein Bax expression was up regulated in a time-dependent manner; the anti-apoptotic protein Bcl-2 was down regulated at 12 h and 24 h time points, but slightly up regulated at 48 h time point.
Regulation (regulated) of Gene_expression (expression) of Bax associated with apoptosis
2) Confidence 0.40 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2222640 Disease Relevance 0.54 Pain Relevance 0
Furthermore, in other brain areas, such as the cerebellum, the cortex or the striatum neither the expression of Bax fusion proteins nor the number of cells expressing the activated form of caspase-3 were modified.
Neg (neither) Regulation (modified) of Gene_expression (expression) of Bax in brain
3) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.93 Pain Relevance 0
No Bax expression was detected in lung tissues obtained from sham-treated animals (Fig. 7Ae, see densitometry analysis 7Ae1).
Regulation (detected) of Gene_expression (expression) of Bax in lung
4) Confidence 0.29 Published 2010 Journal Respir Res Section Body Doc Link PMC2836283 Disease Relevance 0.68 Pain Relevance 0.07
In this study, the decreased expression of Bcl-2, up-regulated expression of caspase-3 and Bax, as well as increased TUNEL positive cells depicted the presence of a global myocardial apoptosis following acute ethanol exposure.
Regulation (regulated) of Gene_expression (expression) of Bax associated with apoptosis
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.74 Pain Relevance 0.08
Activated Akt induces the alteration of Bcl2 and Bax expression and plays an antiapoptotic role in several different cell types [26].
Regulation (alteration) of Gene_expression (expression) of Bax
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.74 Pain Relevance 0.65
One, in which a sufficient number of antagonizing BH3-only molecules are required to adequately sequester anti-apoptotic proteins [6,7], and a second, dependent on the level of BAX expression to successfully activate the apoptotic program.


Regulation (dependent) of Gene_expression (expression) of BAX associated with apoptosis
7) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2964639 Disease Relevance 0.79 Pain Relevance 0
Expression of Bax fusion proteins, activation of caspase-3, as well as cell genesis and neurogenesis were not modified by Dox treatment in the SVZ-OB system, the second main neurogenic area of the adult brain.
Neg (not) Regulation (modified) of Gene_expression (Expression) of Bax in adult brain associated with neurodegenerative disease
8) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.87 Pain Relevance 0
In bright contrast, splenocytes of HS mice showed remarkably divergent values in their Bax and Bcl-2 protein expression levels at t = 0 hours, t = 24 hours, and t = 72 hours after hemorrhage (Figure 4b, left and middle).
Regulation (values) of Gene_expression (expression) of Bax associated with cva and hemorrhagic shock
9) Confidence 0.18 Published 2008 Journal Crit Care Section Body Doc Link PMC2374615 Disease Relevance 0.86 Pain Relevance 0.11
The dependency for presence of BAK/BAX expression on the PR8 induced pore formation in mitochondria defines the role for PR8 PB1-F2 as a BH3 only protein that activates conformational change in the BAX complex within the mitochondria.
Regulation (dependency) of Gene_expression (expression) of BAX in pore
10) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2908617 Disease Relevance 0.92 Pain Relevance 0
Although it is well documented that apoptosis is also regulated by the Bcl-2 family of proteins [55], we do not detect any significant changes in the levels of Bax, Bad, Bcl-2 and Bcl-xL followed by U0126 treatment (data not shown).
Neg (not) Regulation (changes) of Gene_expression (levels) of Bax associated with apoptosis
11) Confidence 0.07 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.68 Pain Relevance 0
MEK1 or MEK2 activation had no significant effect on the expression of the pro-apoptotic proteins Bax and Bak in these cells (data not shown).


Neg (no) Regulation (effect) of Gene_expression (expression) of Bax associated with apoptosis
12) Confidence 0.06 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.66 Pain Relevance 0
The Bcl-2 family includes pro-apoptotic (Bax and Bad) and anti-apoptotic (Bcl-2 and Bcl-XL) proteins, whose expression and activity is regulated through different signaling pathways including trophic factors deprivation, A?
Regulation (regulated) of Gene_expression (expression) of Bax associated with apoptosis
13) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.34 Pain Relevance 0.05

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