INT175508

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Context Info
Confidence 0.85
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 30.00
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
cleavage 20
EL4 2
poly 1
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 43 99.82 Very High Very High Very High
chemokine 21 97.84 Very High Very High Very High
addiction 3 96.08 Very High Very High Very High
imagery 202 95.72 Very High Very High Very High
aspirin 15 89.96 High High
cva 1 78.24 Quite High
Inflammation 52 73.16 Quite High
cINOD 14 69.20 Quite High
cytokine 16 61.52 Quite High
Immobilon 3 45.84 Quite Low
Disease Link Frequency Relevance Heat
Cancer 2381 99.84 Very High Very High Very High
Apoptosis 1307 99.80 Very High Very High Very High
Lymphatic System Cancer 89 99.28 Very High Very High Very High
Death 372 98.08 Very High Very High Very High
Neuroblastoma 96 96.00 Very High Very High Very High
Targeted Disruption 35 95.60 Very High Very High Very High
Skin Cancer 113 95.28 Very High Very High Very High
Lung Injury 102 91.72 High High
Osteoporosis 27 88.48 High High
Hepatocellular Cancer 74 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PARP activity assay and administration of PARP inhibitor
Protein_catabolism (administration) of PARP
1) Confidence 0.85 Published 2008 Journal Crit Care Section Body Doc Link PMC2575597 Disease Relevance 0.51 Pain Relevance 0.10
Subsequently, the level of caspase-3-mediated cleavage of PARP-1 reached a maximum 96 hours post-chemotherapy, which is when ex vivo binding of DAB4 to dead EL4 cells was maximal.
Protein_catabolism (cleavage) of PARP-1 in EL4
2) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.94 Pain Relevance 0
Similarly, the time-dependent cleavage of PARP-1 followed the rapid and transient activation of caspase-3 after cytotoxic drug treatment or ionizing radiation in vitro (data not shown).
Protein_catabolism (cleavage) of PARP-1 in cleavage
3) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.94 Pain Relevance 0.03
We raised the question whether treatment of CEM cells with PADMA 28 causes a caspase 3- or 7-mediated proteolytic cleavage of PARP.
Protein_catabolism (cleavage) of PARP in cleavage
4) Confidence 0.55 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.26 Pain Relevance 0
Additional immunofluorescence studies of tumor tissue after in vivo administration of biotinylated mAb indicated that tumor-bound DAB4 was intimately related to cells containing cleaved PARP1, which is recognized as a marker of late apoptosis (Al-Ejeh et al, accompanying manuscript).
Protein_catabolism (cleaved) of PARP1 associated with cancer and apoptosis
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645682 Disease Relevance 1.13 Pain Relevance 0
Both caspase-3 activation and PARP-1 cleavage as early and late markers of apoptosis, respectively, increased directly as a function of chemotherapy dose.
Protein_catabolism (cleavage) of PARP-1 in cleavage associated with apoptosis
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.83 Pain Relevance 0
Apoptosis was detected in tumors by immunohistochemical analysis of caspase-3 activation and cleavage of poly ADP-ribose-1 (PARP-1).
Protein_catabolism (cleavage) of PARP-1 in poly associated with cancer and apoptosis
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.63 Pain Relevance 0
Activated caspase-3 and cleaved PARP-1 were detected using specific rabbit IgG followed by Alexa546-conjugated goat anti-rabbit IgG (2.5 µg/mL, Molecular Probes-Invitrogen, CA).
Protein_catabolism (cleaved) of PARP-1
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 0.65 Pain Relevance 0.03
Immunohistochemical analysis indicated that tumor activation of caspase-3 became most evident 24 hours after a full dose of chemotherapy (Figure 3A) whereas PARP-1 cleavage was best identified 96 hours post-chemotherapy (Figure 3B).
Protein_catabolism (cleavage) of PARP-1 in cleavage associated with cancer
9) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.58 Pain Relevance 0.05
Immunohistochemical analysis of EL4 tumor caspase-3 activation and PARP-1 cleavage and immunofluorescence analysis of in vivo tumor binding of DAB4
Protein_catabolism (cleavage) of PARP-1 in cleavage associated with cancer
10) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.45 Pain Relevance 0.03
Immunohistochemical measurements of tumor caspase-3 activation and PARP-1 cleavage, which are indicators of early and late apoptosis, respectively, were correlated with tumor accumulation of DAB4.
Protein_catabolism (cleavage) of PARP-1 in cleavage associated with cancer and apoptosis
11) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2645692 Disease Relevance 2.18 Pain Relevance 0.05
Tumor DAB4 accumulation correlated with cumulative caspase-3 activation and PARP-1 cleavage as tumor biomarkers of apoptosis and was directly related to the extended median survival time of tumor-bearing mice.


Protein_catabolism (cleavage) of PARP-1 in cleavage associated with cancer and apoptosis
12) Confidence 0.43 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2645692 Disease Relevance 2.38 Pain Relevance 0.04
Chemotherapy induced dose-dependent caspase-3 activation and PARP-1 cleavage in tumors of EL4 lymphoma-bearing mice (Figure 3).
Protein_catabolism (cleavage) of PARP-1 in EL4 associated with lymphatic system cancer and cancer
13) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.49 Pain Relevance 0.04
PARP cleavage
Protein_catabolism (cleavage) of PARP in cleavage
14) Confidence 0.37 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.32 Pain Relevance 0.09
PARP cleavage kinetic
Protein_catabolism (cleavage) of PARP in cleavage
15) Confidence 0.37 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.23 Pain Relevance 0
This hypothesis is supported by Germain et al. [67] who demonstrate that activation of caspase 7 is involved in cleavage of PARP and apoptosis.
Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
16) Confidence 0.33 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.35 Pain Relevance 0
One of the hallmark of caspase activation is polyadenosine-5'-diphosphate-ribose-polymerase (PARP) cleavage, where the native 116 kD polypeptide is cleaved to a smaller 85 kD fragment.
Protein_catabolism (cleavage) of PARP in cleavage
17) Confidence 0.30 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.22 Pain Relevance 0
TUNEL assay, Annexin-V staining, caspases activation and PARP cleavage unveiled the ability of D6 to cause tumor cell death by triggering apoptosis, similarly to curcumin, but with a stronger and quicker extent.
Protein_catabolism (cleavage) of PARP in cleavage associated with cancer, apoptosis and death
18) Confidence 0.30 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2898702 Disease Relevance 1.91 Pain Relevance 0.04
We assessed if apoptosis was induced like in BetA treated cells by analyzing PARP cleavage.
Spec (analyzing) Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
19) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671171 Disease Relevance 1.13 Pain Relevance 0
Importantly, both, DNA fragmentation and PARP cleavage were blocked when cells were pre-treated with zVAD.fmk (a pan-caspase inhibitor) confirming that both are caspase-mediated events (Figure 2A and 2B).


Protein_catabolism (cleavage) of PARP in cleavage
20) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2671171 Disease Relevance 0.96 Pain Relevance 0

General Comments

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