INT17551

Context Info Confidence 0.70 First Reported 1989 Last Reported 2010 Negated 3 Speculated 2 Reported most in Body Documents 31 Total Number 34 Disease Relevance 15.39 Pain Relevance 6.00

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA) plasma membrane (HLA-DRA) lysosome (HLA-DRA)

Anatomy Link Frequency CD86 12 monocytes 12 T cells 8 epithelial cells 3 vascular endothelium 3 HLA-DRA (Homo sapiens)

Pain Link Frequency Relevance Heat interstitial cystitis 9 99.84 chemokine 40 99.70 cytokine 215 99.56 Inflammation 325 99.16 Neuritis 4 98.16 psoriasis 5 96.52 rheumatoid arthritis 90 95.76 Pain 17 94.88 Crohn's disease 24 94.76 agonist 7 94.52

Disease Link Frequency Relevance Heat Interstitial Cystitis 9 99.84 INFLAMMATION 398 99.16 Optic Neuritis 4 98.16 Apoptosis 29 97.98 Phototoxic Dermatitis 84 97.88 Adhesions 17 97.84 Diabetes Mellitus 12 97.72 Colitis 27 97.64 Disease 168 96.60 Psoriasis 6 96.52

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: Immunohistochemical analysis revealed significantly increased expression of HLA-DR antigen in the glandular cells in eutopic and ectopic endometria, compared with materials from patients with adenomyoma and infertile patients.

Positive_regulation (increased) of Gene_expression (expression) of HLA-DR

1) Confidence 0.70 Published 1993 Journal Fertil. Steril. Section Body Doc Link 8224269 Disease Relevance 0.16 Pain Relevance 0

LPS, added experimentally to whole blood, enhanced HLA-DR expression on monocytes without further manipulation.

Positive_regulation (enhanced) of Gene_expression (expression) of HLA-DR in monocytes

2) Confidence 0.70 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2739399 Disease Relevance 0.08 Pain Relevance 0.12

Experimental and clinical significance of endotoxin-dependent HLA-DR expression on monocytes.

Positive_regulation (dependent) of Gene_expression (expression) of HLA-DR in monocytes

3) Confidence 0.70 Published 1989 Journal J. Surg. Res. Section Title Doc Link 2739399 Disease Relevance 0.06 Pain Relevance 0.10

In both groups the HLA-DR expression was significantly higher in the secretory phase than the proliferative or glandular and stroma cells.

Positive_regulation (higher) of Gene_expression (expression) of HLA-DR in stroma

4) Confidence 0.47 Published 2010 Journal Arch. Gynecol. Obstet. Section Body Doc Link 19585136 Disease Relevance 0 Pain Relevance 0

increased the expression of HLA-DR, particularly on CD14HIGH cells (CD14HIGH: + 263%; CD14LOW: + 87%) (Figure 7).

Positive_regulation (increased) of Gene_expression (expression) of HLA-DR

5) Confidence 0.39 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.25

Minor or irrelevant modifications in CD83 expression were observed (CPZ treated, irradiated cells versus irradiated control, Fig. 3A) and only a slight increase in HLA-DR expression was induced by CPZ under irradiation (Fig. 3B).

Positive_regulation (increase) of Gene_expression (expression) of HLA-DR

6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.13 Pain Relevance 0.07

Plasma concentrations of epinephrine, norepinephrine, cortisol, IL-6 and IL-10 as well as monocyte surface expression of HLA-DR and their ex vivo capacity to release TNF-alpha after LPS stimulation were measured perioperatively.

Positive_regulation (measured) of Gene_expression (expression) of HLA-DR in Plasma

7) Confidence 0.26 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.36 Pain Relevance 0.52

CPZ, a known photosensitizer with photoallergenic and phototoxic properties, was tested with and without irradiation and the induced modulation of CD86, CD83 and HLA-DR expressions as well as cell viability were measured by flow cytometry and compared 48 h after treatment.

Positive_regulation (induced) of Gene_expression (expressions) of HLA-DR in CD86

8) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0 Pain Relevance 0

Dose-dependent increases in CD86 and HLA-DR (but not CD83) expression were observed at radiation doses >1 J/cm2 UVA.

Positive_regulation (increases) of Gene_expression (expression) of HLA-DR in CD86

9) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.28 Pain Relevance 0

Interestingly, photohaptenic properties were also described by Hino et al. [34] where SPFX treatment of THP-1 cells only resulted in enhanced HLA-DR but not CD86 or CD54 expression.

Positive_regulation (resulted) of Gene_expression (expression) of HLA-DR in CD86

10) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.31 Pain Relevance 0.09

Interestingly, photohaptenic properties were also described by Hino et al. [34] where SPFX treatment of THP-1 cells only resulted in enhanced HLA-DR but not CD86 or CD54 expression.

Neg (not) Positive_regulation (enhanced) of Gene_expression (expression) of HLA-DR in CD86

11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.31 Pain Relevance 0.09

The magnitude of that variability was investigated by measuring the expression of CD86, CD83 and HLA-DR on non-irradiated and irradiated, immature PBMDCs.

Spec (investigated) Positive_regulation (measuring) of Gene_expression (expression) of HLA-DR in CD86

12) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.12 Pain Relevance 0

As shown in Figure 8, HLA-DR expression on both CD14HIGH and CD14LOW monocytes was up-regulated by these pathogen-associated molecular patterns (PAMPs), particularly on CD14HIGH cells.

Positive_regulation (regulated) of Gene_expression (expression) of HLA-DR in monocytes

13) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.19

As shown in Figure 8, HLA-DR expression on both CD14HIGH and CD14LOW monocytes was up-regulated by these pathogen-associated molecular patterns (PAMPs), particularly on CD14HIGH cells.

Positive_regulation (-) of Gene_expression (expression) of HLA-DR in monocytes

14) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.19

In AAS, decreased HLA-DR expression already occurred during surgery for the CD14HIGH cells, earlier than that observed for the CD14LOW population and with a more pronounced effect.

Positive_regulation (occurred) of Gene_expression (expression) of HLA-DR

15) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.35 Pain Relevance 0.15

As shown in Figure 8, HLA-DR expression on both CD14HIGH and CD14LOW monocytes was up-regulated by these pathogen-associated molecular patterns (PAMPs), particularly on CD14HIGH cells.

Positive_regulation (up) of Gene_expression (expression) of HLA-DR in monocytes

16) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.19

Furthermore, our data suggest that MARCH1 up-regulation by glucocorticoids might be a key element leading to reduced expression of HLA-DR on both CD14HIGH and CD14LOW monocytes.

Positive_regulation (leading) of Gene_expression (expression) of HLA-DR in monocytes

17) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.27 Pain Relevance 0.09

Increased HLA-DR expression by breast epithelial cells was observed in cases available for study.

Positive_regulation (Increased) of Gene_expression (expression) of HLA-DR in epithelial cells

18) Confidence 0.26 Published 1991 Journal Histopathology Section Abstract Doc Link 1916685 Disease Relevance 0.52 Pain Relevance 0.13

With an irradiation intensity of 1.7 mW/cm2 the HLA-DR expression first decreased (at 0.5 J/cm2) to nearly 75% of the non-irradiated control, and then increased in a dose-dependent manner up to 140% of control (Fig. 1C, white columns).

Positive_regulation (increased) of Gene_expression (expression) of HLA-DR

19) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.13 Pain Relevance 0

Two studies have previously suggested that rs3129882 influences expression of HLA-DR and HLA-DQ.

Positive_regulation (influences) of Gene_expression (expression) of HLA-DR

20) Confidence 0.16 Published 2010 Journal Nat. Genet. Section Abstract Doc Link 20711177 Disease Relevance 0.64 Pain Relevance 0.09

General Comments

This test has worked.