INT175510

Context Info Confidence 0.06 First Reported 2003 Last Reported 2003 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.45 Pain Relevance 0

cytosol (Casp7) peptidase activity (Casp7) cytoplasm (Casp7)

Anatomy Link Frequency cleavage 2 Casp7 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 2 5.00 palliative 2 5.00 metalloproteinase 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 78 99.00 Cancer 144 87.36 Hepatocellular Cancer 72 86.56 Liver Cancer 24 84.40 Death 14 81.24 Severe Combined Immunodeficiency 14 5.00 Cirrhosis 10 5.00 Metastasis 8 5.00 Disease 8 5.00 Cleidocranial Dysplasia 6 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.

Spec (may) Regulation (responsible) of Positive_regulation (activation) of caspase 7 associated with apoptosis

1) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.15 Pain Relevance 0

This hypothesis is supported by Germain et al. [67] who demonstrate that activation of caspase 7 is involved in cleavage of PARP and apoptosis.

Regulation (involved) of Positive_regulation (activation) of caspase 7 in cleavage associated with apoptosis

2) Confidence 0.04 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.30 Pain Relevance 0

General Comments

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