INT175510

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Context Info
Confidence 0.06
First Reported 2003
Last Reported 2003
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp7) peptidase activity (Casp7) cytoplasm (Casp7)
Anatomy Link Frequency
cleavage 2
Casp7 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 78 99.00 Very High Very High Very High
Cancer 144 87.36 High High
Hepatocellular Cancer 72 86.56 High High
Liver Cancer 24 84.40 Quite High
Death 14 81.24 Quite High
Severe Combined Immunodeficiency 14 5.00 Very Low Very Low Very Low
Cirrhosis 10 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.
Spec (may) Regulation (responsible) of Positive_regulation (activation) of caspase 7 associated with apoptosis
1) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.15 Pain Relevance 0
This hypothesis is supported by Germain et al. [67] who demonstrate that activation of caspase 7 is involved in cleavage of PARP and apoptosis.
Regulation (involved) of Positive_regulation (activation) of caspase 7 in cleavage associated with apoptosis
2) Confidence 0.04 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.30 Pain Relevance 0

General Comments

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