INT175511

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Context Info
Confidence 0.09
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.03
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp7) peptidase activity (Casp7) cytoplasm (Casp7)
Anatomy Link Frequency
poly 1
cleavage 1
Casp7 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 156 98.16 Very High Very High Very High
Cancer 288 91.64 High High
Death 28 80.84 Quite High
Hepatocellular Cancer 144 75.00 Quite High
Severe Combined Immunodeficiency 28 74.24 Quite High
Liver Cancer 48 71.64 Quite High
Cirrhosis 20 5.00 Very Low Very Low Very Low
Metastasis 16 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Cleidocranial Dysplasia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the proteolytic cleavage of caspase-3 and caspase-7 plays a central role in PARP cleavage during apoptosis [39], we investigated whether this apoptosis machinery was activated upon U0126 or PD98059 treatment.
Protein_catabolism (cleavage) of caspase-7 in cleavage associated with apoptosis
1) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.82 Pain Relevance 0
The activation of these two caspases and cleaved PARP were determined by Western blot analysis using antibodies capable of detecting cleaved caspase-3, caspase-7 and PARP.
Protein_catabolism (cleaved) of caspase-7
2) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.71 Pain Relevance 0
Cleaved caspase-7 and cleaved caspase-3 fragments were detectable at 24 and 48 hours of U0126 treatment and increased in a dose-dependent manner (Fig. 8A).
Protein_catabolism (Cleaved) of caspase-7
3) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.64 Pain Relevance 0
U0126 induced the release of cytochrome c and increased the cleavage of caspase-3, caspase-7, and poly ADP-ribose polymerase (PARP).
Protein_catabolism (cleavage) of caspase-7 in poly
4) Confidence 0.04 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.85 Pain Relevance 0

General Comments

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