INT175512

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Context Info
Confidence 0.70
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 22.75
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf2) extracellular region (Igf2) carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
colon 14
myometrium 2
Igf2 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 1 60.68 Quite High
pain pelvic 2 50.48 Quite High
Pain 1 45.24 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
metalloproteinase 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1120 100.00 Very High Very High Very High
Colon Cancer 574 99.98 Very High Very High Very High
Adenoma 504 99.88 Very High Very High Very High
Uterine Fibroids 94 99.84 Very High Very High Very High
Cancer 1403 99.74 Very High Very High Very High
Colorectal Cancer 84 99.16 Very High Very High Very High
Aberrant Crypt Foci 588 98.80 Very High Very High Very High
Hyperplasia 29 98.04 Very High Very High Very High
Malignant Neoplastic Disease 58 96.40 Very High Very High Very High
Birth Weight 10 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lymphangiogenesis in colon tumors is not affected by IGF-II overexpression
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-II in colon associated with colon cancer
1) Confidence 0.70 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.89 Pain Relevance 0
Female NMRI mice, overexpressing human IGF-II under the control of the rat phosphoenolpyruvate carboxykinase (PEPCK) promoter in several tissues including colon [24] and their non-transgenic female NMRI littermates were used in this study.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of IGF-II in colon associated with targeted disruption
2) Confidence 0.70 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.09 Pain Relevance 0
Seven microarray studies reviewed by Arslan et al. (2005) reported at least a 2-fold increase in IGF2 expression in fibroids relative to normal myometrium.
Positive_regulation (increase) of Gene_expression (expression) of IGF2 in myometrium associated with uterine fibroids
3) Confidence 0.57 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 1.50 Pain Relevance 0.08
The reduction of cell membrane staining in adenomas from IGF-II transgenic mice was associated with an increased staining of ?
Positive_regulation (transgenic mice) of Gene_expression (transgenic mice) of IGF-II associated with targeted disruption and adenoma
4) Confidence 0.50 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.96 Pain Relevance 0
DMH treatment did not induce the expression of IGF2 in the colon of mice, indicating that the effect of IGF-II on preneoplastic alterations (ACF) in the colon was due to the IGF-II transgene.


Neg (not) Positive_regulation (induce) of Gene_expression (expression) of IGF2 in colon associated with aberrant crypt foci
5) Confidence 0.50 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.46 Pain Relevance 0
Since IGF-II is a positive regulator for proliferation in colon cancer cells [15], it is possible that overexpression of IGF-II may lead to a temporarily higher development of hyperplastic or atypical crypts, which are well detectable by methylene blue staining in the early stage of colon cancer development, but with a higher potential to regress [6].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-II in colon associated with colon cancer and hyperplasia
6) Confidence 0.50 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.95 Pain Relevance 0
In humans IGF-II was suggested to play a role in development of CRC, as substantiated by findings showing that IGF-II is overexpressed in about 44% of all colorectal tumors due to a loss of imprinting (LOI) in the IGF2 gene [13].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IGF-II associated with colorectal cancer and colon cancer
7) Confidence 0.50 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.67 Pain Relevance 0
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

In colorectal cancer insulin-like growth factor II (IGF-II) is frequently overexpressed.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IGF-II in colon associated with targeted disruption, cancer and colon cancer
8) Confidence 0.50 Published 2006 Journal J Carcinog Section Title Doc Link PMC1660565 Disease Relevance 1.63 Pain Relevance 0
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

In colorectal cancer insulin-like growth factor II (IGF-II) is frequently overexpressed.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of insulin-like growth factor II in colon associated with targeted disruption, cancer and colon cancer
9) Confidence 0.50 Published 2006 Journal J Carcinog Section Title Doc Link PMC1660565 Disease Relevance 1.63 Pain Relevance 0
Although not as prominent as observed for IGF-II levels, IGFBP-2 concentrations in the serum of 15 week old transgenic mice were significantly higher than in the serum of wild-type mice (Fig. 1B) and correlated positively with IGF-II levels (P < 0.05, r2 = 0.18; data not shown).
Positive_regulation (observed) of Gene_expression (levels) of IGF-II associated with targeted disruption
10) Confidence 0.50 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.99 Pain Relevance 0
Effects of IGF-II overexpression on the development of colorectal cancer have been investigated previously in the ApcMin/+ mouse, containing a loss-of-function mutation in the Apc gene [29].
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-II associated with colon cancer
11) Confidence 0.47 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.14 Pain Relevance 0
Treatment with DMH did not induce the expression of endogenous IGF-II at the mRNA-level, neither in transgenic animals nor in their non-transgenic littermates with ?
Neg (neither) Positive_regulation (induce) of Gene_expression (expression) of IGF-II associated with targeted disruption
12) Confidence 0.47 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.07 Pain Relevance 0
However, since the liver carcinogen diethylnitrosamine has been shown to induce re-expression of endogenous IGF-II in the liver of mice in a dose-dependent fashion [25], we tested in addition whether DMH influences the IGF2 mRNA expression in the colon.
Positive_regulation (induce) of Gene_expression (expression) of IGF-II in colon
13) Confidence 0.47 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.41 Pain Relevance 0
That overexpression of IGF-II in this model acts as a promotor and not as an initiator of tumor development has to be concluded from similar tumor numbers in IGF-II transgenic and wild-type mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of IGF-II associated with targeted disruption and cancer
14) Confidence 0.47 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.73 Pain Relevance 0
Interestingly, at an early stage of tumor development IGF-II transgenic mice displayed predominantly more ACF containing ?
Positive_regulation (transgenic mice) of Gene_expression (transgenic mice) of IGF-II associated with aberrant crypt foci, targeted disruption and cancer
15) Confidence 0.44 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 2.02 Pain Relevance 0
Thus, the widespread activation of MEK1/2 and phosphorylation of p44 MAPK (ERK1) observed in HCCs could reflect constitutive activation mediated by absence of growth inhibitor [10] or over-expression of ras [44], IGF-II [10], TGF-?
Positive_regulation (over) of Gene_expression (expression) of IGF-II
16) Confidence 0.11 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.62 Pain Relevance 0

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