INT175514

Context Info Confidence 0.50 First Reported 2003 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 5.14 Pain Relevance 0

cytosol (Casp7) peptidase activity (Casp7) cytoplasm (Casp7)

Anatomy Link Frequency poly 1 cleavage 1 Casp7 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 7 5.00 palliative 5 5.00 Bile 5 5.00 imagery 5 5.00 ischemia 2 5.00 Inflammation 2 5.00 cytokine 1 5.00 anesthesia 1 5.00 Inflammatory response 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 202 98.80 Cancer 360 92.20 Hepatocellular Cancer 180 85.60 Liver Cancer 60 83.44 Death 35 80.44 Stress 3 78.16 Shock 3 77.12 Severe Combined Immunodeficiency 35 74.24 Adhesions 5 63.48 Obesity 48 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Genes important for sequential activation of caspases cascade Casp12, Casp7, Prf1, Gzmb were also down-regulated in mice fed with HF diet, however the apoptosis inhibitor proteins Birc2, Birc5 were suppressed.

Positive_regulation (activation) of Casp7 associated with apoptosis

1) Confidence 0.50 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.50 Pain Relevance 0

This hypothesis is supported by Germain et al. [67] who demonstrate that activation of caspase 7 is involved in cleavage of PARP and apoptosis.

Positive_regulation (activation) of caspase 7 in cleavage associated with apoptosis

2) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.29 Pain Relevance 0

We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.

Positive_regulation (activation) of caspase 7 associated with apoptosis

3) Confidence 0.07 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.14 Pain Relevance 0

U0126 induced the release of cytochrome c and increased the cleavage of caspase-3, caspase-7, and poly ADP-ribose polymerase (PARP).

Positive_regulation (increased) of caspase-7 in poly

4) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.86 Pain Relevance 0

Cleaved caspase-7 and cleaved caspase-3 fragments were detectable at 24 and 48 hours of U0126 treatment and increased in a dose-dependent manner (Fig. 8A).

Positive_regulation (increased) of caspase-7

5) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.64 Pain Relevance 0

The activation of these two caspases and cleaved PARP were determined by Western blot analysis using antibodies capable of detecting cleaved caspase-3, caspase-7 and PARP.

Positive_regulation (cleaved) of caspase-7

6) Confidence 0.03 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.71 Pain Relevance 0

General Comments

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