INT175514

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.14
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp7) peptidase activity (Casp7) cytoplasm (Casp7)
Anatomy Link Frequency
poly 1
cleavage 1
Casp7 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 202 98.80 Very High Very High Very High
Cancer 360 92.20 High High
Hepatocellular Cancer 180 85.60 High High
Liver Cancer 60 83.44 Quite High
Death 35 80.44 Quite High
Stress 3 78.16 Quite High
Shock 3 77.12 Quite High
Severe Combined Immunodeficiency 35 74.24 Quite High
Adhesions 5 63.48 Quite High
Obesity 48 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes important for sequential activation of caspases cascade Casp12, Casp7, Prf1, Gzmb were also down-regulated in mice fed with HF diet, however the apoptosis inhibitor proteins Birc2, Birc5 were suppressed.
Positive_regulation (activation) of Casp7 associated with apoptosis
1) Confidence 0.50 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2674043 Disease Relevance 0.50 Pain Relevance 0
This hypothesis is supported by Germain et al. [67] who demonstrate that activation of caspase 7 is involved in cleavage of PARP and apoptosis.
Positive_regulation (activation) of caspase 7 in cleavage associated with apoptosis
2) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.29 Pain Relevance 0
We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.
Positive_regulation (activation) of caspase 7 associated with apoptosis
3) Confidence 0.07 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.14 Pain Relevance 0
U0126 induced the release of cytochrome c and increased the cleavage of caspase-3, caspase-7, and poly ADP-ribose polymerase (PARP).
Positive_regulation (increased) of caspase-7 in poly
4) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.86 Pain Relevance 0
Cleaved caspase-7 and cleaved caspase-3 fragments were detectable at 24 and 48 hours of U0126 treatment and increased in a dose-dependent manner (Fig. 8A).
Positive_regulation (increased) of caspase-7
5) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.64 Pain Relevance 0
The activation of these two caspases and cleaved PARP were determined by Western blot analysis using antibodies capable of detecting cleaved caspase-3, caspase-7 and PARP.
Positive_regulation (cleaved) of caspase-7
6) Confidence 0.03 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.71 Pain Relevance 0

General Comments

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