INT175516

Context Info Confidence 0.10 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.64 Pain Relevance 0

cytosol (Casp7) peptidase activity (Casp7) cytoplasm (Casp7)

Anatomy Link Frequency cleavage 1 Casp7 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 2 5.00 palliative 2 5.00 metalloproteinase 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Apoptosis 78 91.40 Death 14 87.40 Cancer 144 79.40 Liver Cancer 24 67.16 Hepatocellular Cancer 72 59.84 Severe Combined Immunodeficiency 14 5.00 Cirrhosis 10 5.00 Metastasis 8 5.00 Disease 8 5.00 Cleidocranial Dysplasia 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The cleaved caspase-7 and -3 were detected at similar time course as PARP cleavage (Fig. 8A).

Localization (cleavage) of caspase-7 in cleavage

1) Confidence 0.10 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.58 Pain Relevance 0

We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.

Localization (cleaved) of caspase 7 associated with apoptosis

2) Confidence 0.09 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.05 Pain Relevance 0

General Comments

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