INT175518

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.37
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Apaf1) Golgi apparatus (Apaf1) nucleus (Apaf1)
intracellular (Apaf1) cytoplasm (Apaf1)
Apaf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 25 86.40 High High
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Neurotransmitter 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 173 99.96 Very High Very High Very High
Death 64 95.84 Very High Very High Very High
Cancer 145 94.72 High High
Non-small-cell Lung Cancer 1 91.68 High High
Autoimmune Disease 3 88.64 High High
INFLAMMATION 29 86.40 High High
Metastasis 5 77.68 Quite High
Liver Cancer 12 75.60 Quite High
Lung Cancer 93 75.04 Quite High
Disease 134 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of TUSC2 on chemosensitivity was associated with down-regulation of MDM2, accumulation of p53, and activation of the Apaf-1 apoptotic pathway [22].
Positive_regulation (activation) of Apaf-1 associated with apoptosis
1) Confidence 0.15 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2776015 Disease Relevance 1.39 Pain Relevance 0.15
The other involves cytochrome c release-dependent activation of caspase 9 through Apaf-1 [37,38].
Positive_regulation (activation) of Apaf-1
2) Confidence 0.12 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.92 Pain Relevance 0
As shown in Figure 4, caspases are activated both by the many stimuli that trigger the mitochondrial intrinsic cascade (Bax, citochrome C/Apaf-1, caspase-9 and caspases-3/-7), and by the extrinsic pathways (DD receptors, caspase-8, caspase-3).
Positive_regulation (trigger) of Apaf-1
3) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.06 Pain Relevance 0

General Comments

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