INT175520

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 48.93
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igf2) extracellular region (Igf2) carbohydrate metabolic process (Igf2)
Anatomy Link Frequency
colon 8
myometrium 1
embryos 1
muscles 1
lung 1
Igf2 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 3 97.46 Very High Very High Very High
anesthesia 36 91.88 High High
tolerance 68 90.24 High High
Bile 12 87.72 High High
fibrosis 60 81.32 Quite High
Somatostatin 13 79.20 Quite High
ischemia 13 75.00 Quite High
withdrawal 8 65.64 Quite High
Inflammation 90 65.32 Quite High
pain pelvic 4 61.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2198 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 230 100.00 Very High Very High Very High
Prostate Cancer 90 100.00 Very High Very High Very High
Colon Cancer 1108 99.98 Very High Very High Very High
Injury 63 99.96 Very High Very High Very High
Adenoma 987 99.88 Very High Very High Very High
Uterine Fibroids 188 99.84 Very High Very High Very High
Cancer 2700 99.74 Very High Very High Very High
Death 23 99.20 Very High Very High Very High
Colorectal Cancer 162 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Female NMRI mice, overexpressing human IGF-II under the control of the rat phosphoenolpyruvate carboxykinase (PEPCK) promoter in several tissues including colon [24] and their non-transgenic female NMRI littermates were used in this study.
Gene_expression (overexpressing) of IGF-II in colon associated with targeted disruption
1) Confidence 0.78 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.09 Pain Relevance 0
DMH treatment did not induce the expression of IGF2 in the colon of mice, indicating that the effect of IGF-II on preneoplastic alterations (ACF) in the colon was due to the IGF-II transgene.


Gene_expression (expression) of IGF2 in colon associated with aberrant crypt foci
2) Confidence 0.78 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.45 Pain Relevance 0
However, since the liver carcinogen diethylnitrosamine has been shown to induce re-expression of endogenous IGF-II in the liver of mice in a dose-dependent fashion [25], we tested in addition whether DMH influences the IGF2 mRNA expression in the colon.
Gene_expression (expression) of IGF-II in colon
3) Confidence 0.78 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.41 Pain Relevance 0
DMH-treatment does not affect IGF-II expression
Gene_expression (expression) of IGF-II
4) Confidence 0.78 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.06 Pain Relevance 0
Lymphangiogenesis in colon tumors is not affected by IGF-II overexpression
Gene_expression (overexpression) of IGF-II in colon associated with colon cancer
5) Confidence 0.78 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.89 Pain Relevance 0
Although it has not been demonstrated so far that IGF-II affects ?
Gene_expression (affects) of IGF-II
6) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.07 Pain Relevance 0
In humans IGF-II was suggested to play a role in development of CRC, as substantiated by findings showing that IGF-II is overexpressed in about 44% of all colorectal tumors due to a loss of imprinting (LOI) in the IGF2 gene [13].
Gene_expression (overexpressed) of IGF-II associated with colorectal cancer and colon cancer
7) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.67 Pain Relevance 0
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

In colorectal cancer insulin-like growth factor II (IGF-II) is frequently overexpressed.

Gene_expression (overexpressed) of IGF-II in colon associated with targeted disruption, cancer and colon cancer
8) Confidence 0.67 Published 2006 Journal J Carcinog Section Title Doc Link PMC1660565 Disease Relevance 1.63 Pain Relevance 0
IGF-II transgenic mice display increased aberrant colon crypt multiplicity and tumor volume after 1,2-dimethylhydrazine treatment

In colorectal cancer insulin-like growth factor II (IGF-II) is frequently overexpressed.

Gene_expression (overexpressed) of insulin-like growth factor II in colon associated with targeted disruption, cancer and colon cancer
9) Confidence 0.67 Published 2006 Journal J Carcinog Section Title Doc Link PMC1660565 Disease Relevance 1.63 Pain Relevance 0
Although not as prominent as observed for IGF-II levels, IGFBP-2 concentrations in the serum of 15 week old transgenic mice were significantly higher than in the serum of wild-type mice (Fig. 1B) and correlated positively with IGF-II levels (P < 0.05, r2 = 0.18; data not shown).
Gene_expression (levels) of IGF-II associated with targeted disruption
10) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.93 Pain Relevance 0
Identification of PEPCK-IGF-II transgenic animals and carcinogen treatment
Gene_expression (animals) of IGF-II associated with targeted disruption
11) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.03 Pain Relevance 0
Although not as prominent as observed for IGF-II levels, IGFBP-2 concentrations in the serum of 15 week old transgenic mice were significantly higher than in the serum of wild-type mice (Fig. 1B) and correlated positively with IGF-II levels (P < 0.05, r2 = 0.18; data not shown).
Gene_expression (levels) of IGF-II associated with targeted disruption
12) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 0.99 Pain Relevance 0
This difference in ACF development was no longer present after additional 29 weeks (IGF-II transgenic: 15.67 ± 3.12 per 10 cm2 versus wild-type: 15.56 ± 4.45 per 10 cm2) (Fig. 2B).
Gene_expression (transgenic) of IGF-II associated with targeted disruption and aberrant crypt foci
13) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.27 Pain Relevance 0
The reduction of cell membrane staining in adenomas from IGF-II transgenic mice was associated with an increased staining of ?
Gene_expression (transgenic mice) of IGF-II associated with targeted disruption and adenoma
14) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.96 Pain Relevance 0
Since IGF-II is a positive regulator for proliferation in colon cancer cells [15], it is possible that overexpression of IGF-II may lead to a temporarily higher development of hyperplastic or atypical crypts, which are well detectable by methylene blue staining in the early stage of colon cancer development, but with a higher potential to regress [6].
Gene_expression (overexpression) of IGF-II in colon associated with colon cancer and hyperplasia
15) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.95 Pain Relevance 0
-catenin/TCF/LEF complex [52] it was not astonishing that we observed significantly higher IGFBP-2 serum levels in IGF-II transgenic mice and a positive correlation between serum IGF-II and IGFBP-2.
Gene_expression (transgenic mice) of IGF-II associated with targeted disruption
16) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.41 Pain Relevance 0
The almost complete loss of membrane staining was restricted to adenomas from IGF-II transgenic mice (Fig. 5Be,f, Table 2).
Gene_expression (transgenic mice) of IGF-II associated with targeted disruption and adenoma
17) Confidence 0.67 Published 2006 Journal J Carcinog Section Body Doc Link PMC1660565 Disease Relevance 1.90 Pain Relevance 0
One candidate hormone for this process is mouse placental lactogen II because its placental expression has been linked to that of Igf2 (25), it regulates pancreatic ?
Gene_expression (expression) of Igf2
18) Confidence 0.64 Published 2010 Journal Diabetes Section Body Doc Link PMC2797934 Disease Relevance 0.40 Pain Relevance 0.07
Two studies in mice have reported that exposure of fetuses to induced maternal diabetes and of embryos before implantation to in vitro insulin affected expression of two imprinted neighboring genes, H19 and IGF2, by altering their methylation status and resulted in changes in fetal development and birth weight (Shao et al. 2007, 2008).
Gene_expression (expression) of IGF2 in embryos associated with birth weight and gestational diabetes
19) Confidence 0.63 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 1.51 Pain Relevance 0.15
Seven microarray studies reviewed by Arslan et al. (2005) reported at least a 2-fold increase in IGF2 expression in fibroids relative to normal myometrium.
Gene_expression (expression) of IGF2 in myometrium associated with uterine fibroids
20) Confidence 0.63 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854766 Disease Relevance 1.44 Pain Relevance 0.03

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