INT175524

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Context Info
Confidence 0.20
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 2.74
Pain Relevance 2.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
cleavage 2
upper 2
Neuro-2a 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 77 99.98 Very High Very High Very High
Nerve growth factor 45 99.28 Very High Very High Very High
Clonidine 26 98.72 Very High Very High Very High
Spinal cord 9 96.64 Very High Very High Very High
agonist 14 92.20 High High
antagonist 12 91.20 High High
allodynia 39 89.36 High High
opioid receptor 84 88.56 High High
Kinase C 118 86.64 High High
intrathecal 10 83.60 Quite High
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 108 98.88 Very High Very High Very High
Obesity 24 94.64 High High
Insulin Resistance 61 90.00 High High
Neuropathic Pain 48 89.36 High High
Stress 7 86.92 High High
Cancer 249 81.04 Quite High
Apoptosis 128 81.04 Quite High
Bacillus Anthracis Infection 13 74.36 Quite High
Death 25 74.00 Quite High
Ganglion Cysts 39 69.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatments with anti-NGF at 6 and 7 wk of age significantly decreased the phosphorylation of p38 in LDRG of db/db mice at 8 wk of age (Fig. 3A).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Fig associated with nerve growth factor
1) Confidence 0.20 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.40 Pain Relevance 0.90
Overexpression of SOD1 reduced phosphorylation of CREB (Fig. 5).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Fig
2) Confidence 0.18 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.09 Pain Relevance 0
The effect produced by GW3965 on glucose uptake was parallel to a downregulation of socs3 and ptp1b gene expression and to the recovery of insulin phosphorylation of AKT (Fig. 7).
Negative_regulation (recovery) of Phosphorylation (phosphorylation) of Fig
3) Confidence 0.15 Published 2008 Journal Diabetes Section Body Doc Link PMC2584126 Disease Relevance 0.46 Pain Relevance 0.29
Again, administration of LNNA or naltrindole before morphine prevented the phosphorylation of NMDAR subunits and the activation of CaMKII as well (Fig. 4).
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of Fig associated with morphine
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.31
Although phosphorylation was reduced in all mutants, mutation of S17 and T21 caused maximal reduction in BMAL1 phosphorylation (Fig. 3C).
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Fig
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0 Pain Relevance 0
However, MyD88-deficient cells show a delay in the phosphorylation of c-jun N-terminal kinase (JNK) stimulated by LPS (Fig.
Negative_regulation (delay) of Phosphorylation (phosphorylation) of Fig
6) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
However, co-expression of PlexinA1 correlated with reduced autophosphorylation of both Fps and Fer (Fig. 4A, upper).
Negative_regulation (reduced) of Phosphorylation (autophosphorylation) of Fig in upper
7) Confidence 0.10 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.13 Pain Relevance 0.06
We observed that 5 h treatment of REC with LeTx cause amino terminal cleavage of MEK1 and loss of ERK phosphorylation (Fig. 3C).
Negative_regulation (loss) of Phosphorylation (phosphorylation) of Fig in cleavage
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.13 Pain Relevance 0
Furthermore, the binding of rhSp1 to the + 9/+ 49 and the + 46/+ 90 regions was decreased by phosphorylation with purified CK2 (Fig. 4B).


Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Fig
9) Confidence 0.08 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0
Figure 4 demonstrates that U0126 and PD98059 inhibited phosphorylation of MAPK while SB203580, SP600125 and LY294002 effectively blocked phosphorylation of p38 kinase and JNK and Akt-1 respectively (Fig. 4A).
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Fig
10) Confidence 0.05 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.45 Pain Relevance 0
The influence of U0126 on cell growth and viability occurred at the dose expected to suppress phosphorylation of MAPK (Fig. 8).
Negative_regulation (suppress) of Phosphorylation (phosphorylation) of Fig
11) Confidence 0.05 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.50 Pain Relevance 0
Figure 4 demonstrates that U0126 and PD98059 inhibited phosphorylation of MAPK while SB203580, SP600125 and LY294002 effectively blocked phosphorylation of p38 kinase and JNK and Akt-1 respectively (Fig. 4A).
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of Fig
12) Confidence 0.05 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.53 Pain Relevance 0
Western blot analysis in Fig. 3 demonstrates the levels of ERK phosphorylation in Neuro-2a control and Neuro-2a-Ng cells after treatment with 300 nM PMA for 0, 10, 30, 60, 180, 360 min.
Negative_regulation (levels) of Phosphorylation (phosphorylation) of Fig in Neuro-2a
13) Confidence 0.05 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.06 Pain Relevance 0.05
To test this possibility, we assayed phosphorylation of Akt (Fig. 7C) in tissues incubated with clonidine (1 ?
Negative_regulation (assayed) of Phosphorylation (phosphorylation) of Fig associated with clonidine
14) Confidence 0.04 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.35

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