INT175525

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 7.02
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Map2k1) cytoplasm (Map2k1) cytosol (Map2k1)
cell proliferation (Map2k1) mitosis (Map2k1) cell motility (Map2k1)
Anatomy Link Frequency
cleavage 2
Map2k1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 222 98.56 Very High Very High Very High
imagery 6 90.72 High High
Inflammation 22 65.08 Quite High
cytokine 23 63.88 Quite High
spinal inflammation 30 55.92 Quite High
psoriasis 6 52.00 Quite High
Arthritis 30 51.20 Quite High
Kinase C 3 50.40 Quite High
Bile 5 48.00 Quite Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 426 99.70 Very High Very High Very High
Hepatocellular Cancer 180 99.32 Very High Very High Very High
Malignant Neoplastic Disease 11 98.92 Very High Very High Very High
Rheumatoid Arthritis 222 98.56 Very High Very High Very High
Apoptosis 203 98.04 Very High Very High Very High
Liver Cancer 60 95.76 Very High Very High Very High
Carcinoma 9 83.56 Quite High
Adenoma 2 82.96 Quite High
Colon Cancer 45 81.60 Quite High
Bacillus Anthracis Infection 13 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The best-characterized of the Ras effector pathways is the activation of the Raf family Ser/Thr kinases, leading to sequential phosphorylation and activation of MEK1/MEK2 and the mitogen-activated protein (MAP) kinases ERK1/ERK2 [8].
Positive_regulation (leading) of Phosphorylation (phosphorylation) of MEK1
1) Confidence 0.33 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.90 Pain Relevance 0
We found that anti-BRAF autoantibodies activate the in vitro phosphorylation of MEK1 mediated by BRAF.


Positive_regulation (activate) of Phosphorylation (phosphorylation) of MEK1
2) Confidence 0.27 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 1.17 Pain Relevance 0.70
In summary, we have shown that high expression levels of MAPK, phosphorylated MAPK and phosphorylated MEK1/2 are found in tumors of HCC patients.
Positive_regulation (levels) of Phosphorylation (phosphorylated) of MEK1 associated with cancer and hepatocellular cancer
3) Confidence 0.22 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.37 Pain Relevance 0
Immunostaining of the blots displayed a marked increase in phosphorylated MEK1/2 (Fig. 2A, 2B &2C).
Positive_regulation (increase) of Phosphorylation (phosphorylated) of MEK1
4) Confidence 0.22 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.33 Pain Relevance 0
Approximately 7-fold increase in MEK1/2 phosphorylation was detected in HCC as compared with ABL tissues (Fig. 2D).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MEK1 associated with hepatocellular cancer
5) Confidence 0.21 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.29 Pain Relevance 0
Only tumor cells exhibit elevated MEK1/2 phosphorylation.
Positive_regulation (elevated) of Phosphorylation (phosphorylation) of MEK1 associated with cancer
6) Confidence 0.21 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.84 Pain Relevance 0.05
Thus, the widespread activation of MEK1/2 and phosphorylation of p44 MAPK (ERK1) observed in HCCs could reflect constitutive activation mediated by absence of growth inhibitor [10] or over-expression of ras [44], IGF-II [10], TGF-?
Positive_regulation (activation) of Phosphorylation (phosphorylation) of MEK1
7) Confidence 0.21 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.68 Pain Relevance 0
We observed that 5 h treatment of REC with LeTx cause amino terminal cleavage of MEK1 and loss of ERK phosphorylation (Fig. 3C).
Positive_regulation (cause) of Phosphorylation (phosphorylation) of MEK1 in cleavage
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737623 Disease Relevance 0.13 Pain Relevance 0
Among 20 purified autoantibodies to BRAF, 1 inhibited and 13 activated MEK1 phosphorylation (Figure 3).
Positive_regulation (activated) of Phosphorylation (phosphorylation) of MEK1
9) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991030 Disease Relevance 0.69 Pain Relevance 0.29
Anti-BRAF autoantibodies activate the in vitro phosphorylation of MEK1 mediated by BRAF.


Positive_regulation (activate) of Phosphorylation (phosphorylation) of MEK1
10) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2991030 Disease Relevance 0.62 Pain Relevance 0.34

General Comments

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