INT175526

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 73
Total Number 74
Disease Relevance 21.08
Pain Relevance 7.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
nucleus 2
platelets 2
neurons 2
upper 2
macrophages 1
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
cocaine 88 100.00 Very High Very High Very High
nMDA receptor 20 100.00 Very High Very High Very High
Nucleus accumbens 19 100.00 Very High Very High Very High
Morphine 159 99.70 Very High Very High Very High
Nerve growth factor 49 99.00 Very High Very High Very High
Clonidine 47 98.72 Very High Very High Very High
ischemia 97 98.40 Very High Very High Very High
Dopamine 93 97.16 Very High Very High Very High
Spinal cord 31 96.64 Very High Very High Very High
antagonist 48 94.36 High High
Disease Link Frequency Relevance Heat
Colon Cancer 91 100.00 Very High Very High Very High
Skin Cancer 29 99.06 Very High Very High Very High
Hepatocellular Cancer 182 98.88 Very High Very High Very High
Shock 524 98.84 Very High Very High Very High
Aging 267 98.52 Very High Very High Very High
Insulin Resistance 261 98.44 Very High Very High Very High
Cv Unclassified Under Development 82 98.40 Very High Very High Very High
Targeted Disruption 403 98.12 Very High Very High Very High
Apoptosis 371 98.12 Very High Very High Very High
Obesity 444 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, neglecting dams have increased optical density for phosphorylated DARPP-32 (pDARPP-32) immunoreactivity within the nucleus accumbens and CP (Fig. 7).
Phosphorylation (phosphorylated) of Fig in nucleus accumbens associated with nucleus accumbens
1) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
Interestingly, CaMKIV KO mice displayed significantly lower freezing during the pre-tone period at 28 days after training (Fig. 5C right; F1,38?
Phosphorylation (right) of Fig associated with targeted disruption
2) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2830479 Disease Relevance 0.68 Pain Relevance 0.05
In the experiment shown in Fig. 7C, the inhibitors slightly diminished the firing rate of the GHRH neuron (?
Phosphorylation (shown) of Fig in neuron
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.25
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Phosphorylation (phosphorylation) of Fig
4) Confidence 0.50 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Phosphorylation (phosphorylation) of Fig
5) Confidence 0.50 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
Unlike rapamycin, which has previously been identified as a possible therapeutic due to its upregulation of autophagy, rilmenidine had no effect on phosphorylation of p70 S6 kinase (Fig. 1G), S6 protein (Fig. 1H) or 4E-BP1 (Fig. 1I), all downstream substrates of mTOR kinase activity.


Phosphorylation (phosphorylation) of Fig
6) Confidence 0.50 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2865373 Disease Relevance 0.16 Pain Relevance 0
phosphorylation (Fig. 4A, pIR?
Phosphorylation (phosphorylation) of Fig
7) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.05 Pain Relevance 0
consistent with the increase of Akt phosphorylation (Fig. 8E).
Phosphorylation (phosphorylation) of Fig
8) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.22 Pain Relevance 0
phosphorylation (Fig. 4A, lane 2).
Phosphorylation (phosphorylation) of Fig
9) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.22 Pain Relevance 0
HS+MES also enhanced the cell surface translocation in mice skeletal muscle of GLUT4 (Fig.
Phosphorylation (skeletal muscle) of Fig in skeletal muscle associated with shock
10) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 1.30 Pain Relevance 0
Because DNA–PK was reported to phosphorylate H2AX (Stiff et al., 2004), one might ask whether the reduced DNA–PK activity (Fig. 5) could be contradictory to H2AX phosphorylation.
Phosphorylation (phosphorylation) of Fig
11) Confidence 0.40 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2867301 Disease Relevance 0.56 Pain Relevance 0
Treatments with anti-NGF at 6 and 7 wk of age significantly decreased the phosphorylation of p38 in LDRG of db/db mice at 8 wk of age (Fig. 3A).
Phosphorylation (phosphorylation) of Fig associated with nerve growth factor
12) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.40 Pain Relevance 0.89
phosphorylation on Ser9 (Fig. 6, 7).
Phosphorylation (phosphorylation) of Fig
13) Confidence 0.36 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2910663 Disease Relevance 0 Pain Relevance 0
Indeed, while wortmannin (WT) inhibited both the activation of Akt (Fig. 4B, top) and SphK1 (Fig. 4B, bottom) induced by DHT, the SphK1 inhibitor SKI-2 did not impact Akt phosphorylation (Fig. 4B, top).
Phosphorylation (phosphorylation) of Fig
14) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779655 Disease Relevance 0 Pain Relevance 0.03
Reasonably, baseline ERK phosphorylation in the normal retina (Fig. 1) is likely to play a physiologic role in the UPS-mediated degradation of synaptophysin for the maintenance of synaptic plasticity (25–27).
Phosphorylation (phosphorylation) of Fig in retina
15) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.16 Pain Relevance 0
Consistent with previous report, HepG2 cells exposed to high glucose concentration (25 mM) exhibited reduced insulin-stimulated Akt phosphorylation (Fig. 8A, [34]).
Phosphorylation (phosphorylation) of Fig
16) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.67 Pain Relevance 0
ADH transgene itself did not elicit any effect on the phosphorylation of AMPK and ACC (Fig. 7).
Phosphorylation (phosphorylation) of Fig
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Last but not the least, ADH transgene itself did not affect LKB1 phosphorylation (Fig. 8).


Phosphorylation (phosphorylation) of Fig
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
It is thus likely that ACh stimulation activates the upregulated RhoA (Fig. 5), resulting in a greater phosphorylation of MLC (Fig. 6) and contraction of BSMs in AHR mice.
Phosphorylation (phosphorylation) of Fig
19) Confidence 0.32 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.43 Pain Relevance 0.20
Moreover, targeting TLR2 in the host or in the melanoma cells markedly inhibited the B16 cell-induced phosphorylation of Stat3 (Fig. 3F).
Phosphorylation (phosphorylation) of Fig associated with skin cancer
20) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.58 Pain Relevance 0.04

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