INT175531

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Context Info
Confidence 0.33
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.53
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
nucleus accumbens 2
endothelial cells 2
neuron 2
upper 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 19 100.00 Very High Very High Very High
Morphine 155 99.70 Very High Very High Very High
cocaine 46 99.56 Very High Very High Very High
ischemia 36 98.40 Very High Very High Very High
antagonist 31 94.80 High High
agonist 20 93.12 High High
opioid receptor 168 92.56 High High
Kinase C 81 86.08 High High
cytokine 12 84.72 Quite High
Periaqueductal grey 36 84.36 Quite High
Disease Link Frequency Relevance Heat
Skin Cancer 8 99.22 Very High Very High Very High
Cv Unclassified Under Development 35 98.40 Very High Very High Very High
Pancreatic Cancer 61 91.76 High High
Asthma 8 89.00 High High
Toxicity 4 87.96 High High
Necrosis 7 85.64 High High
Cancer 206 85.28 High High
Urological Neuroanatomy 37 84.36 Quite High
INFLAMMATION 11 84.32 Quite High
Stress 29 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, neglecting dams have increased optical density for phosphorylated DARPP-32 (pDARPP-32) immunoreactivity within the nucleus accumbens and CP (Fig. 7).
Positive_regulation (increased) of Phosphorylation (phosphorylated) of Fig in nucleus accumbens associated with nucleus accumbens
1) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.37
In the experiment shown in Fig. 7C, the inhibitors slightly diminished the firing rate of the GHRH neuron (?
Positive_regulation (experiment) of Phosphorylation (shown) of Fig in neuron
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.25
consistent with the increase of Akt phosphorylation (Fig. 8E).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of Fig
3) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.28 Pain Relevance 0
It is thus likely that ACh stimulation activates the upregulated RhoA (Fig. 5), resulting in a greater phosphorylation of MLC (Fig. 6) and contraction of BSMs in AHR mice.
Positive_regulation (resulting) of Phosphorylation (phosphorylation) of Fig
4) Confidence 0.19 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0.43 Pain Relevance 0.20
Moreover, targeting TLR2 in the host or in the melanoma cells markedly inhibited the B16 cell-induced phosphorylation of Stat3 (Fig. 3F).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Fig associated with skin cancer
5) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 0.58 Pain Relevance 0.04
induced p65 nuclear translocation and p65 phosphorylation (Fig. 4B, right), suggesting that MA suppresses TNF?
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Fig
6) Confidence 0.15 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 0.48 Pain Relevance 0
Similarly as cocaine, 10-5 to 10-7M benztropine produced gaps between endothelial cells (not shown). 10-5 to 10-7M cocaine treatment of BMVEC’s induced phosphorylation of Erk 1/2, MARSKC and MLC (Fig. 2).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of Fig in endothelial cells associated with cocaine
7) Confidence 0.13 Published 2008 Journal The Open Virology Journal Section Body Doc Link PMC2678818 Disease Relevance 0 Pain Relevance 0.47
The Akt pool was activated by the phosphorylation of Thr308 and Ser473 residues (Fig. 1, upper panel).
Positive_regulation (activated) of Phosphorylation (phosphorylation) of Fig in upper
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0.08 Pain Relevance 0.81
Again, administration of LNNA or naltrindole before morphine prevented the phosphorylation of NMDAR subunits and the activation of CaMKII as well (Fig. 4).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of Fig associated with morphine
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.30
Immunostaining of the blots displayed a marked increase in phosphorylated MEK1/2 (Fig. 2A, 2B &2C).
Positive_regulation (increase) of Phosphorylation (phosphorylated) of Fig
10) Confidence 0.06 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.34 Pain Relevance 0
I15 induced a significant decrease in mTOR phosphorylation at the Ser2448 site, which was restored to control levels upon reperfusion (R30 or R3d), with the exception of CA1 SHC that had increased Ser2448 phosphorylation (Fig. 6; supplemental Fig.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of Fig associated with ischemia
11) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.10

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