INT175532

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.73
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Parp1) nuclear envelope (Parp1) nucleolus (Parp1)
nucleus (Parp1) protein complex (Parp1) transcription factor binding (Parp1)
Anatomy Link Frequency
poly 3
cleavage 1
Parp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 32 86.68 High High
ketamine 1 51.48 Quite High
anesthesia 5 22.88 Low Low
tolerance 1 18.96 Low Low
Bioavailability 2 13.04 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 227 99.96 Very High Very High Very High
Cancer 328 99.24 Very High Very High Very High
Pancreatic Cancer 61 97.60 Very High Very High Very High
Rheumatoid Arthritis 3 92.48 High High
Genomic Instability 3 91.88 High High
Death 43 87.40 High High
Ataxia 9 87.12 High High
INFLAMMATION 39 86.68 High High
Anaplastic Astrocytoma 1 84.12 Quite High
Colon Cancer 1 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PARP, poly(ADP-ribose) polymerase
Localization (polymerase) of PARP in poly
1) Confidence 0.74 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.35 Pain Relevance 0
Both ATM and PARP-1 are localised in foci after DNA damage.
Localization (localised) of PARP-1
2) Confidence 0.74 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0 Pain Relevance 0
The data presented in this study strongly support a role for PARP-1 and poly (ADP-ribose) in ATM activation: in the absence of PARP-1 there is a deficient ATM-kinase activation in response to ionizing radiation as measured by intrinsic kinase activity and H2AX phosphorylation.
Neg (absence) Localization (absence) of PARP-1 in poly
3) Confidence 0.74 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC1868035 Disease Relevance 0.21 Pain Relevance 0
Immunohistochemical localization of nitrotyrosine, PARP, ICAM-1, P-Selectin, Bax, Bcl-2, TNF-?
Localization (localization) of PARP
4) Confidence 0.60 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2844385 Disease Relevance 0 Pain Relevance 0.03
It suppresses the expression of cyclin D1, which is deregulated in several types of tumor, and it also induces apoptosis in tumor cells by activating caspase-8, which leads to cleavage of Bid, thus resulting in sequential release of mitochondrial cytochrome c and activation of caspase-9 and caspase-3, cleavage of poly ADP ribose polymerase (PARP) and apoptosis of tumor cells.
Localization (cleavage) of PARP in poly associated with cancer and apoptosis
5) Confidence 0.34 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2898702 Disease Relevance 1.10 Pain Relevance 0.06
-induced caspase and PARP apoptotic signaling pathway while suppresses TNF?
Localization (caspase) of PARP associated with apoptosis
6) Confidence 0.33 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2907730 Disease Relevance 1.46 Pain Relevance 0.08
The cleaved caspase-7 and -3 were detected at similar time course as PARP cleavage (Fig. 8A).
Localization (cleavage) of PARP in cleavage
7) Confidence 0.25 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 0.51 Pain Relevance 0
We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.
Localization (cleaved) of PARP associated with apoptosis
8) Confidence 0.25 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.06 Pain Relevance 0
We did, however, observe an increase in cleaved caspase 3, cleaved caspase 7, cleaved PARP and cytoplasmic cytochrome c in U0126 treated cells indicating that cytochrome c release following U0126 treatment may be responsible for the activation of both caspase 7 and 3 which, in turn, induce apoptosis.
Localization (cleaved) of PARP associated with apoptosis
9) Confidence 0.25 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.05 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox