INT175535

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.17
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GPC3) extracellular region (GPC3) proteinaceous extracellular matrix (GPC3)
plasma membrane (GPC3)
Anatomy Link Frequency
blood vessels 1
hepatocyte 1
cartilage 1
synovium 1
GPC3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 100.00 Very High Very High Very High
ketamine 27 99.70 Very High Very High Very High
Arthritis 52 96.24 Very High Very High Very High
rheumatoid arthritis 78 95.92 Very High Very High Very High
Pain 40 95.88 Very High Very High Very High
allodynia 38 95.08 Very High Very High Very High
Neuropathic pain 14 79.92 Quite High
palliative 1 79.72 Quite High
depression 4 76.12 Quite High
hyperpathia 2 74.88 Quite High
Disease Link Frequency Relevance Heat
Seronegative Spondarthritis 48 96.24 Very High Very High Very High
Rheumatoid Arthritis 78 95.92 Very High Very High Very High
Pain 43 95.88 Very High Very High Very High
Neuropathic Pain 56 95.08 Very High Very High Very High
Hepatocellular Cancer 36 93.28 High High
Osteoarthritis 36 90.36 High High
Adhesions 12 86.76 High High
Cancer 80 86.68 High High
Sleep Disorders 2 85.12 High High
Hallucination 2 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, hepatocyte growth factor and c-met, c-ErbB-2, u-plasminogen activator, MXR7, MDM2, MAGE, matrix metalloproteinase, Smads, p53, pRB, p16INK4, p21WAF1/CIP1, p27Kip1, PTEN, E-cadherin, ?
Gene_expression (/) of MXR7 in hepatocyte associated with metalloproteinase
1) Confidence 0.29 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317301 Disease Relevance 1.18 Pain Relevance 0.13
Furthermore, when five of the differentially expressed genes identified in the earlier rat arrays (cartilage oligomeric matrix protein (COMP), GPC3, matrix Gla protein (MGP), pleiotrophin (PTN) and vimentin (VIM)) were studied in the canine tissues, only 2 (COMP and MGP - markers of AC cells rather than NP cells) demonstrated a similar pattern in the canine IVD.
Gene_expression (studied) of GPC3 in cartilage
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0.09 Pain Relevance 0
With the exception of KRT18, KRT19 and PTN, the genes identified in rat studies (GPC3, ANXA3, VIM, COMP and MGP) and canine studies (A2M, ANXA4, DSC2, NCAM1) did not show a substantial differential expression in bovine NP cells compared with AC&AF cells.
Gene_expression (expression) of GPC3
3) Confidence 0.20 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875656 Disease Relevance 0 Pain Relevance 0
By contrast, glypican-1 and glypican-3 were not detectable indicating that there is specificity in glypican expression in the synovium.
Neg (not) Gene_expression (detectable) of glypican-3 in synovium
4) Confidence 0.09 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.51 Pain Relevance 0.14
However, expression of syndecan-4, glypican-1 and glypican-3 was detected in the epidermis (fig 5B,D,F) and blood vessels of human skin, similar to that previously reported,8 providing a positive control for these antibodies.
Gene_expression (expression) of glypican-3 in blood vessels
5) Confidence 0.09 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2563418 Disease Relevance 0.88 Pain Relevance 0.36
He then consented for Ketamine – Bupivacaine SGB infusion after he was explained the experimental nature of the treatment and informed about possible psychomimetic side effects.
Gene_expression (infusion) of SGB associated with ketamine
6) Confidence 0.06 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2584055 Disease Relevance 1.53 Pain Relevance 1.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox