INT175555

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Context Info
Confidence 0.78
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 14.83
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CASR) signal transducer activity (CASR)
Anatomy Link Frequency
parathyroid glands 2
plasma 1
MCF-7 1
duct 1
MDA-MB-231 1
CASR (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 390 100.00 Very High Very High Very High
agonist 13 100.00 Very High Very High Very High
antagonist 12 100.00 Very High Very High Very High
Glutamate 19 78.12 Quite High
gABA 1 55.12 Quite High
Glutamate receptor 3 51.40 Quite High
Pain 21 50.00 Quite Low
fibrosis 10 35.24 Quite Low
Lasting pain 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 690 100.00 Very High Very High Very High
Hypercalcemia 366 100.00 Very High Very High Very High
Disease 145 95.04 Very High Very High Very High
Osteoporosis 7 85.92 High High
Chondrodysplasia 1 82.24 Quite High
Breast Cancer 109 73.60 Quite High
Diabetes Insipidus 1 72.80 Quite High
Disorders Of Creatine Metabolism 20 72.40 Quite High
Fasciculation 4 66.32 Quite High
Cancer 60 51.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the functional significance of CaR expression in pancreatic acinar and duct cells in the pathogenesis of pancreatitis remains to be defined.
Gene_expression (expression) of CaR in duct associated with pancreatitis
1) Confidence 0.78 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.34 Pain Relevance 0.06
The CaR plays a key role in calcium homeostasis and is widely expressed in tissues including kidney, parathyroid glands and bone cells which are involved in calcium metabolism [24].
Gene_expression (expressed) of CaR in kidney
2) Confidence 0.78 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.23 Pain Relevance 0
It is possible that a specific pattern of CaSR expression in our patient has been responsible for the described findings.
Gene_expression (expression) of CaSR
3) Confidence 0.73 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907400 Disease Relevance 0.23 Pain Relevance 0
The other family members who had no clinical signs for FHH (normal plasma and urinary Ca2+ excretion; Tab.2) did not have a CASR gene mutation in exon 4.
Gene_expression (excretion) of CASR in plasma associated with hypercalcemia
4) Confidence 0.67 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 0.77 Pain Relevance 0
While a heterozygous inactivating CASR mutation leads to FHH, homozygous mutations result in severe neonatal pHPT.
Gene_expression (mutation) of CASR associated with hypercalcemia
5) Confidence 0.67 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.49 Pain Relevance 0.07
While a heterozygous inactivating CASR mutation leads to FHH, homozygous mutations result in severe neonatal pHPT.
Gene_expression (leads) of FHH associated with hypercalcemia
6) Confidence 0.67 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.50 Pain Relevance 0.07
Of the eight mammalian groups, four are represented in amphioxus while the branches of TAS1Rs, CASR, GPRC6A and V2Rs are missing.
Gene_expression (branches) of CASR
7) Confidence 0.65 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2246102 Disease Relevance 0 Pain Relevance 0.15
We describe a family with members suffering from both CP and familial hypocalciuric hypercalcemia (FHH) to investigate the association of calcium sensing receptor gene (CASR) and SPINK1 mutations with CP.


Gene_expression (mutations) of calcium sensing receptor associated with hypercalcemia and chronic pancreatitis
8) Confidence 0.59 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.47 Pain Relevance 0.60
CaR, calcium sensing receptor; CASR, calcium receptor gene; CP, chronic pancreatitis; FHH, familial hypocalciuric hypercalcemia; HP, hereditary pancreatitis; ICP, idiopathic chronic pancreatitis; PRSS1; cationic trypsinogen gene; SPINK1, serine protease inhibitor Kazal type 1 gene.


Gene_expression (gene) of calcium sensing receptor associated with pancreatitis, hypercalcemia and chronic pancreatitis
9) Confidence 0.59 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.59 Pain Relevance 0.90
We describe a family with members suffering from both CP and familial hypocalciuric hypercalcemia (FHH) to investigate the association of calcium sensing receptor gene (CASR) and SPINK1 mutations with CP.


Gene_expression (mutations) of CASR associated with hypercalcemia and chronic pancreatitis
10) Confidence 0.59 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.41 Pain Relevance 0.59
For example, the mammalian CASR gene is known to be expressed in parathyroid glands and its loss in parathyroid gland in mice is implicated in hypercalcemia, hyperparathyroidism and growth retardation [66].
Gene_expression (expressed) of CASR in parathyroid glands associated with hypercalcemia
11) Confidence 0.52 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2396169 Disease Relevance 0.61 Pain Relevance 0
The CaR plays a key role in calcium homeostasis and is widely expressed in tissues including kidney, parathyroid glands and bone cells which are involved in calcium metabolism [24].
Gene_expression (expressed) of CaR in parathyroid glands
12) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.23 Pain Relevance 0
CaR, calcium sensing receptor; CASR, calcium receptor gene; CP, chronic pancreatitis; FHH, familial hypocalciuric hypercalcemia; HP, hereditary pancreatitis; ICP, idiopathic chronic pancreatitis; PRSS1; cationic trypsinogen gene; SPINK1, serine protease inhibitor Kazal type 1 gene.


Gene_expression (gene) of CaR associated with pancreatitis, hypercalcemia and chronic pancreatitis
13) Confidence 0.26 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.60 Pain Relevance 0.91
Calcium-sensing receptor (CaR) agonist (NPS R-467) and antagonist were kindly provided by Dr J Fox (NPS Pharmaceuticals, Salt Lake City, UT, USA).
Gene_expression (provided) of CaR associated with antagonist and agonist
14) Confidence 0.25 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0 Pain Relevance 0.10
The CaR is expressed in MDA-MB-231 and MCF-7 cells [31].
Gene_expression (expressed) of CaR in MCF-7
15) Confidence 0.22 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.18 Pain Relevance 0.09
Calcium-sensing receptor (CaR) agonist (NPS R-467) and antagonist were kindly provided by Dr J Fox (NPS Pharmaceuticals, Salt Lake City, UT, USA).
Gene_expression (provided) of Calcium-sensing receptor associated with antagonist and agonist
16) Confidence 0.22 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0 Pain Relevance 0.10
The CaR is expressed in MDA-MB-231 and MCF-7 cells [31].
Gene_expression (expressed) of CaR in MDA-MB-231
17) Confidence 0.08 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374955 Disease Relevance 0.18 Pain Relevance 0.09

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