INT175558

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Context Info
Confidence 0.47
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.55
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CASR) signal transducer activity (CASR)
Anatomy Link Frequency
plasma 2
kidney 2
parathyroid 1
CASR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 175 79.56 Quite High
Pain 16 75.80 Quite High
Neuropathic pain 2 69.04 Quite High
Chronic pancreatitis 78 50.00 Quite Low
adenocard 32 50.00 Quite Low
Potency 28 35.04 Quite Low
antagonist 38 30.40 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
Lasting pain 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 74 100.00 Very High Very High Very High
Pancreatitis 138 96.08 Very High Very High Very High
Bone Cancer 2 95.76 Very High Very High Very High
Chronic Renal Failure 5 95.32 Very High Very High Very High
Congenital Anomalies 2 94.56 High High
Disease 31 91.12 High High
Renal Disease 3 90.96 High High
Hypocalcemia 2 78.64 Quite High
Pain 18 75.80 Quite High
Disorders Of Creatine Metabolism 4 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The other family members who had no clinical signs for FHH (normal plasma and urinary Ca2+ excretion; Tab.2) did not have a CASR gene mutation in exon 4.
Neg (not) Positive_regulation (have) of CASR in plasma associated with hypercalcemia
1) Confidence 0.47 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 0.76 Pain Relevance 0
Cinacalcet (Sensipar®, Amgen, USA), a type II calcimimetic, allosterically increases the sensitivity of the calcium-sensing receptor, lowering the threshold for activation, and thereby decreasing secretion of parathyroid hormone (PTH) [1].
Positive_regulation (increases) of calcium-sensing receptor in parathyroid
2) Confidence 0.41 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2907400 Disease Relevance 0.95 Pain Relevance 0.14
FHH is a benign disorder with a slight elevation of plasma Ca2+.
Positive_regulation (elevation) of FHH in plasma associated with hypercalcemia
3) Confidence 0.41 Published 2003 Journal BMC Gastroenterol Section Body Doc Link PMC317302 Disease Relevance 1.15 Pain Relevance 0
In the GPCR field, cinacalcet, an allosteric enhancer of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in dialysis patients suffering from chronic kidney disease [11].
Positive_regulation (enhancer) of calcium-sensing receptor in kidney associated with chronic renal failure and hypercalcemia
4) Confidence 0.12 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0.34 Pain Relevance 0.23
In the GPCR field, cinacalcet, an allosteric enhancer of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in dialysis patients suffering from chronic kidney disease [11].
Positive_regulation (enhancer) of CaR in kidney associated with chronic renal failure and hypercalcemia
5) Confidence 0.12 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2625337 Disease Relevance 0.34 Pain Relevance 0.23

General Comments

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