INT175563

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.16
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 14
Disease Relevance 11.35
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (NAA50) cytoplasm (NAA50)
Anatomy Link Frequency
extracellular matrix 2
muscles 1
SAN 1
NAA50 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 171 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
Action potential 203 98.48 Very High Very High Very High
Fibrositis 24 96.74 Very High Very High Very High
Osteoarthritis 18 94.38 High High
rheumatoid arthritis 12 33.92 Quite Low
metalloproteinase 28 16.96 Low Low
Nav1.1 7 15.12 Low Low
fibrosis 14 5.00 Very Low Very Low Very Low
action potential duration 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 186 100.00 Very High Very High Very High
Depression 183 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
Vomiting 8 100.00 Very High Very High Very High
Anorexia 7 100.00 Very High Very High Very High
Xerostomia 4 100.00 Very High Very High Very High
Anxiety 4 100.00 Very High Very High Very High
Constipation 4 100.00 Very High Very High Very High
Fatigue 8 99.96 Very High Very High Very High
Obesity 39 99.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, there is electrophysiological evidence of an enlargement of the SAN: Alings and Bouman [3] showed that, in the rabbit and cat, the SAN region with a ‘slow action potential’ increases with age—it has been suggested that this is responsible for the decline in SAN function [4].
Negative_regulation (decline) of SAN associated with action potential
1) Confidence 0.16 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.54 Pain Relevance 0.18
Manifestations of sick sinus syndrome include bradycardia, SAN arrest, and SAN exit block [2].
Negative_regulation (block) of SAN in SAN associated with heart rate under development
2) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.56 Pain Relevance 0.09
It has been suggested that the age-dependent decline in SAN function is the result of a loss of nodal cells and a compensatory proliferation of the interstitium [8,9].
Negative_regulation (decline) of SAN
3) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.16 Pain Relevance 0.15
It is concluded that the age-dependent decline in SAN function is associated with a structural remodelling of the SAN: an increase in SAN tissue, a hypertrophy of the SAN cells and a remodelling of the extracellular matrix.
Negative_regulation (decline) of SAN in extracellular matrix associated with hypertrophy
4) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.26 Pain Relevance 0
The age-dependent decline in SAN function has been suggested to be the result of a decline in INa (see Introduction).
Negative_regulation (decline) of SAN
5) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.22 Pain Relevance 0.03
It is concluded that the age- (and/or obesity-) dependent decline in SAN function is associated with a structural remodelling of the SAN: an enlargement of the SAN, a hypertrophy of the SAN cells, and a remodelling of the extracellular matrix.



Negative_regulation (decline) of SAN in extracellular matrix associated with hypertrophy and obesity
6) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Abstract Doc Link PMC2845824 Disease Relevance 0.36 Pain Relevance 0.07
The mechanisms underlying the age-dependent decline in SAN function are unclear.
Negative_regulation (decline) of SAN
7) Confidence 0.12 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.55 Pain Relevance 0.13
The symptoms included in this list were: Lack of energy, tiredness, lack of appetite, pain, constipation, nausea, dry mouth, depression, anxiety, difficulty sleeping, tenseness, vomiting, shortness of breath, lack of sexual interest, irritability, nervousness, heartburn, dizziness, sore muscles, and numbness or tingling of the hands or feet.


Negative_regulation (lack) of anxiety in muscles associated with pain, constipation, depression, vomiting, gastroesophageal reflux disease, xerostomia, anorexia, hypesthesia, dizziness, fatigue, anxiety and dyspnea
8) Confidence 0.04 Published 2003 Journal BMC Cancer Section Body Doc Link PMC317311 Disease Relevance 1.66 Pain Relevance 0.15
Overall, Tai Chi was positively associated with reduced anxiety using one or more anxiety measures, but overall study quality was modest.


Negative_regulation (reduced) of anxiety associated with anxiety disorder
9) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2893078 Disease Relevance 1.30 Pain Relevance 0.26
The authors observed a significant decline in anxiety for women, but an insignificant decline in anxiety for men.
Negative_regulation (decline) of anxiety associated with anxiety disorder
10) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2893078 Disease Relevance 0.94 Pain Relevance 0.06
Two RCTs and 6 NRS with 359 participants including patients with symptomatic osteoarthritis [34], healthy adults [37,50-52], elderly with cardiovascular disease risk factors [38], individuals with fibromyalgia [53], and adolescents with ADHD [54] found that Tai Chi practiced 2 to 4 times a week (30 to 60 minutes/time) for 5 to 24 weeks was associated with a significant reduction in anxiety (ES, 0.66; 95% CI, 0.29 to 1.03) (Figure 2b) with I2 = 76%.


Negative_regulation (reduction) of anxiety associated with cardiovascular disease, anxiety disorder, attention deficit hyperactivity disorder, fibrositis and osteoarthritis
11) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2893078 Disease Relevance 1.65 Pain Relevance 0.17
The authors observed a significant decline in anxiety for women, but an insignificant decline in anxiety for men.
Negative_regulation (decline) of anxiety associated with anxiety disorder
12) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2893078 Disease Relevance 0.95 Pain Relevance 0.05
The other NRS by Mills et al reported a nonsignificant decrease in tension-anxiety in 8 adults with Multiple Sclerosis [58].
Negative_regulation (decrease) of anxiety associated with anxiety disorder and demyelinating disease
13) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2893078 Disease Relevance 0.94 Pain Relevance 0.06
Results from 2 RCTs with 134 subjects reported that Tai Chi practice for a single 1 hour session [39], or twice a week for 60 minutes/time over 8 weeks was associated with a significant reduction in anxiety scores both among HIV patients[55] and healthy adults [39,40,56].
Negative_regulation (reduction) of anxiety associated with acquired immune deficiency syndrome or hiv infection and anxiety disorder
14) Confidence 0.01 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2893078 Disease Relevance 1.27 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox