INT175570

Context Info Confidence 0.21 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 2.07 Pain Relevance 0

lyase activity (Pcbd1) nucleus (Pcbd1) cytoplasm (Pcbd1)

Anatomy Link Frequency cilia 1 Pcbd1 (Mus musculus)

Pain Link Frequency Relevance Heat Earache 10 5.00 Pain 6 5.00 headache 6 5.00 nud 2 5.00

Disease Link Frequency Relevance Heat Kartagener Syndrome 108 100.00 Gynecomastia 32 97.44 Handedness 2 88.92 Mental Disorders 4 55.20 Syndrome 22 50.00 Ciliary Diskinesia 2 11.88 Earache 10 5.00 Nicotine Addiction 10 5.00 Gastroesophageal Reflux Disease 10 5.00 Bronchiectasis 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Twenty respondents reported that other members of their family had PCD.

Positive_regulation (had) of PCD associated with kartagener syndrome

1) Confidence 0.21 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC317322 Disease Relevance 1.33 Pain Relevance 0

Although there is no direct evidence that patients with PCD also show defects in the cilia in the nodal region, the simultaneous occurrence of defects both in 9+2 cilia and 9+0 cilia in Hfh4 null mice [26], and in mice with the human DNAH5 mutation which occurs in PCD [27], suggests that it is probably the case.

Positive_regulation (occurs) of PCD in cilia associated with kartagener syndrome

2) Confidence 0.21 Published 2003 Journal BMC Pulm Med Section Body Doc Link PMC317322 Disease Relevance 0.74 Pain Relevance 0

General Comments

This test has worked.