INT175580

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Context Info
Confidence 0.76
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 30
Disease Relevance 18.84
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (APOE) aging (APOE) Golgi apparatus (APOE)
lipid metabolic process (APOE) cytoplasm (APOE) lipid binding (APOE)
Anatomy Link Frequency
adipocytes 6
leukocyte 2
BFA 2
macrophages 1
liver 1
APOE (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 130 99.48 Very High Very High Very High
Inflammation 100 89.84 High High
imagery 18 84.12 Quite High
dexamethasone 47 73.16 Quite High
cva 1 70.56 Quite High
alcohol 4 57.28 Quite High
cytokine 6 49.12 Quite Low
Central nervous system 9 40.96 Quite Low
carbamazepine 1 11.92 Low Low
antidepressant 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 468 100.00 Very High Very High Very High
Disease 287 100.00 Very High Very High Very High
Obesity 1094 99.76 Very High Very High Very High
Depression 162 99.48 Very High Very High Very High
Cognitive Disorder 106 99.20 Very High Very High Very High
Stress 44 99.06 Very High Very High Very High
Unconsciousness 8 98.14 Very High Very High Very High
Atherosclerosis 171 98.04 Very High Very High Very High
Cardiovascular Disease 95 97.92 Very High Very High Very High
Stroke 11 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it is noteworthy that inhibition of adenylate cyclase or PKA does not modify the activator effect of apoA-I on apoE secretion (data not shown).
Localization (secretion) of apoE
1) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.34 Pain Relevance 0
Indeed, the activation of apoE secretion by apoA-I may not only lead to an optimum increase in the size of the HDLs, but also to an increase in the uptake of these particles by the liver via the apoB/E LDLR according to the amount of apoE present.
Localization (secretion) of apoE in liver
2) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.44 Pain Relevance 0
In addition, no data is currently available on the signalling pathways involved in the apoA-I induced secretion of apoE.
Localization (secretion) of apoE
3) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.33 Pain Relevance 0
The regulation of apoE secretion by apoA-I, is neither dependent upon an increase in gene transcription, nor upon increased release from the Golgi (figures 5 and 6).
Localization (secretion) of apoE
4) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.18 Pain Relevance 0
In addition, apoA-I also stimulates the secretion of apolipoprotein E (apoE); this action is probably partially dependent on ABCA1 [4].
Localization (secretion) of apoE associated with disorder of lipid metabolism
5) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.78 Pain Relevance 0
ApoA-I increases apoE secretion with minimal effect upon apoE gene expression
Localization (secretion) of apoE
6) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.38 Pain Relevance 0
We show here that apoA-I strongly stimulates apoE secretion, suggesting that in pathological conditions, such as obesity, the combination of low HDL-c levels (carrying apoA-I) and oxidative stress contributes to a major reduction in adipocyte apoE secretion.
Localization (secretion) of apoE in adipocyte associated with stress, obesity and disorder of lipid metabolism
7) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.80 Pain Relevance 0.07
Our investigation clearly shows that apoA-I effectively increases the release of cholesterol, as well as largely increasing the secretion of apoE by mature adipocytes (figures 1 and 5).
Localization (secretion) of apoE in adipocytes associated with obesity
8) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.51 Pain Relevance 0
We show here that apoA-I strongly stimulates apoE secretion, suggesting that in pathological conditions, such as obesity, the combination of low HDL-c levels (carrying apoA-I) and oxidative stress contributes to a major reduction in adipocyte apoE secretion.
Localization (secretion) of apoE in adipocyte associated with stress, obesity and disorder of lipid metabolism
9) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 1.05 Pain Relevance 0.11
In addition, apoA-I also stimulates the secretion of apolipoprotein E (apoE); this action is probably partially dependent on ABCA1 [4].
Localization (secretion) of apolipoprotein E associated with disorder of lipid metabolism
10) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.78 Pain Relevance 0
The apoE is highly implicated in the regulation of lipid metabolism, in the expression of certain adipocyte genes, and in the proliferation of pre-adipocytes [7,27,28], with the secretion of apoE being controlled during adipocyte differentiation [29].
Localization (secretion) of apoE in adipocyte associated with obesity
11) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.68 Pain Relevance 0.03
In addition to increasing cholesterol efflux, apoA-I is known to activate apoE secretion, at least in macrophages.
Localization (secretion) of apoE in macrophages
12) Confidence 0.76 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.32 Pain Relevance 0
AD, Alzheimer's disease; APOE, apolipoprotein E; CAMCOG, Cambridge Cognitive Examination; CERAD, The Consortium to Establish a Registry for Alzheimer's Disease; CI, confidence interval; HLA, human leukocyte antigen; NINCDS-ADRDA, National Institute of Neurological, Communicative Diseases and Stroke-Alzheimer's Disease and Related Diseases Association; NK, natural killer; OPTIMA, Oxford Project to Investigate Memory and Ageing; PCR, polymerase chain reaction; SSP, sequence-specific primers; TNF, tumour necrosis factor

Competing interests

Localization (disease) of APOE in leukocyte associated with necrosis, cognitive disorder, aging, cancer, stroke, disease and disorder of lipid metabolism
13) Confidence 0.73 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764414 Disease Relevance 1.34 Pain Relevance 0
It is also reported that ApoE ?
Localization (reported) of ApoE
14) Confidence 0.73 Published 2003 Journal Ann Gen Hosp Psychiatry Section Body Doc Link PMC317342 Disease Relevance 1.24 Pain Relevance 0.38
Recently, it was reported that APOE-?
Localization (reported) of APOE
15) Confidence 0.73 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2515306 Disease Relevance 1.06 Pain Relevance 0
4 allele and presence of ApoE ?
Localization (allele) of ApoE
16) Confidence 0.71 Published 2006 Journal Osteoporos Int Section Body Doc Link PMC1820757 Disease Relevance 0.66 Pain Relevance 0.03
Furthermore, brefeldin A (BFA), an intracellular trafficking inhibitor, reduces basal cholesterol and apoE secretion, but does not modify induction by apoA-I.
Localization (secretion) of apoE in BFA
17) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2917427 Disease Relevance 0.86 Pain Relevance 0
Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes

Background

Localization (secretion) of apoE in adipocytes associated with obesity
18) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Title Doc Link PMC2917427 Disease Relevance 0.78 Pain Relevance 0
We demonstrate that apoA-I induces a strong increase in cholesterol release and apoE secretion from adipocytes, whereas it has no transcriptional effect on ABCA1 or apoE genes.
Localization (secretion) of apoE in adipocytes associated with obesity
19) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2917427 Disease Relevance 0.89 Pain Relevance 0
Brefeldin A inhibits basal apoE secretion but not apoA-I induced apoE secretion
Localization (secretion) of apoE
20) Confidence 0.67 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.29 Pain Relevance 0

General Comments

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